7,335 research outputs found
Enhancing the dynamic temperature stability of epoxy with graphene oxide
No full textTemperature-dependence mechanism of composites under dynamic loadings is essential for designing the aircraft with harsh operation environment. In this work, the dynamic compression mechanical behavior of graphene oxide modified epoxy (GO-epoxy) was systematically investigated over the temperature range from 298K to 423K under the loading strain rate of 5000 s(-1). The results indicate that the compression properties of GO-epoxy are sensitive to the strain rate and temperature. The yield strength of pure epoxy and GO-epoxy under dynamic loading were twice those under quasi-static loading. The strength gradually decreases as the temperature increases, but the temperature stability of GO-epoxy is significantly improved compared to the pure epoxy. The addition of GO helps to inhibit the movement of the molecular chain, suppress the stress softening, prevent the evolution of the micro-cracks and then increase the thermal stability of epoxy. The high speed photograph combined with the digital image correction (DIC) method indicates that GO improves the impact resistance of epoxy at different temperatures and the interfacial interactions contribute to this strengthening mechanism. A modified temperature and rate-dependent empirical constitutive model was developed to describe the dynamic behavior of pure/GO epoxy. The fracture morphologies show the difference failure modes between the GO-epoxy and the pure epoxy. This work on the temperature dependent dynamic behavior of GO modified epoxy could provide guidance for understanding the dynamic strengthening and thermal softening behaviors of nano-reinforcing composites
Adult pityriasis lichenoides-like mycosis fungoides with high density of CD8-positive T lymphocytic infiltration.
No full textIn vitro phagocytosis of occlusion bodies of nucleopolyhedroviruses by insect cell lines.
No full textCharacterization of an integrative and conjugative element ICEKp1 associated genomic heterogeneity in a Klebsiella pneumoniae strain isolated from a primary liver abscess.
No full textThe 3’-to-5’ exoribonuclease (encoded by HP1248) of Helicobacter pylori regulates motility and apoptosis-inducing genes.
No full textserum-induced iron-azquisition system and TonB contribute to virulence in Klebsiella pneumoniae causing primary liver abscess
No full textComparison of electromyographic activities between asymptomatic young and middle-aged adults during repetitive neck movements
No full textAbstract 1446: Effect of PF-03475952, a potent and neutralizing CD44 antibody, on cancer cell apoptosis in vitro and metastasis in two orthotopic models
No full textAbstract
Effect of PF-03475952, a potent and neutralizing CD44 antibody, on cancer cell apoptosis in vitro and metastasis in two orthotopic models
Yuli Wang, Jean wang, Gary Li, Amy Jackson-Fisher, Brett Simmons, Eugenia Kraynov, Christy Ji, Baiyong Li, and David Pocalyko
Pfizer Global Research & Development, San Diego, CA 92121
CD44 is a cell surface glycoprotein that has multiple functions. It can act as a receptor for ligands such as hyaluronic acid and osteopontin. Additionally, it can function as co-receptor to modulate the activation of growth factor receptors such as c-met & ERBB. CD44 can also influence cell signaling through interaction with components of the actin cytoskeleton such as the ERM protein.
CD44 expression is increased in many types of human cancer. It is also a cell surface marker for cancer stem cells in breast cancer and HCC. In HCC, CD44 overexpression is a frequent event (∼30% based on several reports) and CD44 up regulation is associated with metastasis and poor patient survival. Down regulation of CD44 with RNAi knockdown or neutralizing antibody has been reported to reduce tumor metastasis, recurrence, and growth in different models.
PF-03475952 is a fully human IgG2 anti-CD44 monoclonal antibody that was initially developed as a potential therapeutic agent for rheumatoid arthritis. It was shown previously that the PF-03475952 can disrupt the interaction of CD44 with its ligand, hyaluronic acid. The antibody binding induces loss of CD44 from the cell surface, and inhibits LPS-induced cytokine release from various leukocytes.
In this report, we evaluated the potential of PF-03475952 as a cancer adjuvant therapy for HCC. HCC is the third most deadly forms of cancer world-wide with frequent early recurrence due to inter and extra hepatic metastasis. The effect of PF-03475952 on cancer metastasis was first demonstrated in an M24met melanoma model. The expression of CD44 and the effects of PF-03475952 on HCC cell lines were then characterized. In vitro, PF-03475952 was able to reduce cell adhesion and promote apoptosis in a CD44-dependent manner. More importantly, PF-03475952 can reduce lung metastasis in a CD44-positive HCC orthotopic model.
The study suggested that the CD44 neutralizing antibody, PF-03475952, could be an efficacious agent as adjuvant therapy to prevent cancer metastasis.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1446.</jats:p
Contextual metrical invisibility
No full textIn some languages, certain vowels are invisible to syllable-sensitive processes, but only in certain contexts. This paper argues that metrically invisible vowels are undominated by a syllable node in prosodic structure. Considering mainly Mohawk and Passamaquoddy, the behavior of these "weak vowels" is derived from pressure to avoid using weak vowels as syllable nuclei, countered by pressure to realize underlying segments in well-formed syllables. Because not only epenthetic vowels can be weak vowels, their unsuitability as syllable nuclei is derived representationally, through amount of underlying prosodic structure. Existing analyses of the data are critiqued, and the theoretical implications and potential extensions are discussed.The definitive version of this paper was published in PF: Papers at the Interface (1997) and is available at http://mitwpl.mit.edu/catalog/mwpl30/Hagstrom, P. (1997). Contextual metrical invisibility. In B. Bruening, Y. Kang, & M. McGinnis (Eds.) PF: Papers at the interface (pp. 113-181). Cambridge, MA: Department of Linguistics and Philosophy, Massachusetts Institute of Technology
A generalization of Mehta-Wang determinant and Askey-Wilson polynomials
No full textInternational audienceMotivated by the Gaussian symplectic ensemble, Mehta and Wang evaluated the determinant in 2000. When , Ciucu and Krattenthaler computed the associated Pfaffian with an application to the two dimensional dimer system in 2011. Recently we have generalized the latter Pfaffian formula with a -analogue by replacing the Gamma function by the moment sequence of the little -Jacobi polynomials. On the other hand, Nishizawa has found a q-analogue of the Mehta–Wang formula. Our purpose is to generalize both the Mehta-Wang and Nishizawa formulae by using the moment sequence of the little -Jacobi polynomials. It turns out that the corresponding determinant can be evaluated explicitly in terms of the Askey-Wilson polynomials
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