378 research outputs found
sj-pdf-2-pic-10.1177_09544062211026343 - Supplemental material for Comprehensive performance analysis of a shearer drum in a complicated seam based on discrete element method
No full textSupplemental material, sj-pdf-2-pic-10.1177_09544062211026343 for Comprehensive performance analysis of a shearer drum in a complicated seam based on discrete element method by Lijuan Zhao, Meichen Zhang, Baisheng Shi, Xionghao Liu and Yadong Wang in Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science</p
sj-pdf-3-pic-10.1177_09544062211026343 - Supplemental material for Comprehensive performance analysis of a shearer drum in a complicated seam based on discrete element method
No full textSupplemental material, sj-pdf-3-pic-10.1177_09544062211026343 for Comprehensive performance analysis of a shearer drum in a complicated seam based on discrete element method by Lijuan Zhao, Meichen Zhang, Baisheng Shi, Xionghao Liu and Yadong Wang in Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science</p
sj-pdf-1-pic-10.1177_09544062211026343 - Supplemental material for Comprehensive performance analysis of a shearer drum in a complicated seam based on discrete element method
No full textSupplemental material, sj-pdf-1-pic-10.1177_09544062211026343 for Comprehensive performance analysis of a shearer drum in a complicated seam based on discrete element method by Lijuan Zhao, Meichen Zhang, Baisheng Shi, Xionghao Liu and Yadong Wang in Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science</p
Aurora
No full textThis paper is in support of my artist-based thesis research entitled Aurora. My practice is interdisciplinary with a focus on installation and sculpture, consistently engaged in questions surrounding culturally inherited power structures and resulting modes of representation. This thesis research critically investigates what is understood as “traditional” in North American domestic ornamentation through considerations of complicated and intertwined histories, commerce, personal memory and taste. This paper provides an art historical and contemporary art context for this line of artistic investigation. Focusing on contemporary artists, this paper seeks to highlight the current discourse around culturally inherited materials, in particular of those from hybridized cultural identities. Drawing from theorists engaged in Marxism, post- structuralism, post-modernism; a nuanced understanding of ornament as a commodity and social signifier is highlighted. An account for the breadth of my material research is outlined in this document, focusing on three major works that were exhibited in defense of this thesis, Aurora, Secret Garden and Like Countless Men on Horseback. A focus is emphasized around sets of gestural responses to materials; these are drawing, casting, tracing, folding, cutting, and staging. These gestures invite viewers to think through their own understanding of domestic ornamentation and inherited social structures, as they focus on perceptions of appropriation, nostalgia, monumentality and memory. This paper concludes with implications of this research. That networks of associations to the self, class and history resound through the maintenance of domestic ornamentation. These networks are not static and fluctuate through trend, social norms and ideas surrounding domesticity. Thus it is paramount that in the creation of works invested in this dialogue that ambiguity is facilitated to gain entry into layered, and possibly contradictory associations to the ornamentation of the home. The accumulation of my cultural identity, lived experience, influences and biases will continue to be investigated and articulated through my practice vis-à-vis symbolic socially constructed materials and beliefs
Distinction – 1er et 2e Prix de thèse de l'AFEC décernés à Jospeh Ciaudo et Nolwenn Salmon
No full textRemise du prix de thèse de l’AFEC Vendredi 8 décembre 2017, vers 17h30 S.E. Ambassadeur Monsieur Zhang Ming-Zhong, représentant du Bureau de Taipei en France et Madame Lu Meichen, directrice du Service éducation, remettront le prix de thèse de l’AFEC aux lauréat-e-s. 1er prix : · Joseph Ciaudo (INALCO) pour sa thèse intitulée « Sinodicée en question : Essai d’histoire intellectuelle à partir des discours culturalistes de Zhang Junmai (1919-1931) », sous la direction de Frédéric Wang (IN..
Xenobiotic Receptor PXR-Mediated Resistance to Salmonella Invasion and Its Mechanism
No full textPregnane X receptor (PXR) is a ligand-activated nuclear receptor that regulates gene expression of the metabolizing enzymes that are involved in detoxification of endogenous and exogenous compounds in the gastrointestinal (GI) tract. In recent years, PXR has been found to have novel functions in maintenance of homeostasis of the GI tract, as mice deficient in PXR have spontaneous intestinal inflammation. Because the GI tract homeostasis is maintained through interactions between microbiota and host intestinal cells, we investigated the role of PXR in regulating the susceptibility of the colon cells to Salmonella infection. Using PXR-transfected HCT116 and HT29 cell lines we found that PXR transfected cells were resistant to the Salmonella infection and the resistance was dependent on the PXR activation by the typical PXR agonists rifampicin (RIF) and hyperforin. Furthermore, the ligand-dependent resistance could be antagonized by the PXR antagonist ketoconazole, confirming the role of PXR in resistance. In an earlier study, we found NF-B activation by LPS to inhibit PXR activity, and, consistent with the observation, LPS treatment of the cells weakened the resistance of the PXR-transfected cells to Salmonella infection. To understand the mechanism of the PXR-regulated resistance, we analyzed the role of PXR in regulating the intestinal barrier gene expressions such as occludin, ZO-1, and claudin, and found that occludin expression was significantly up-regulated by the PXR activation. Taken together, our results suggest that PXR plays a role in regulating GI tract resistance to pathogenic bacterial infection and provides a potential therapeutic approach for treatment of Salmonella infection
A Comparative Review of Research on Corporate Social Responsibility Reporting in Domestic and Abroad
No full textDevelopment of Broad-Acting Enterosorbents for the Mitigation of Toxin Exposures During Outbreaks and Emergencies
No full textPeople and animals can be unintentionally exposed to mixtures of hazardous mycotoxins and environmental chemicals following natural and man-made disasters through contaminated food, feed supplies and drinking water. To develop effective sorbents to sequester and detoxify mixtures of toxins, we have amended parent calcium and sodium montmorillonite clays with the natural nutrients L-carnitine and choline to enhance the lipophilicity of the clay surfaces. Additionally, montmorillonite clays were processed and activated by sulfuric acid to simulate activated carbon���s porosity and surface area. Clay-based enterosorbent therapy has been reported in previous animal and human clinical trials confirming the safety and efficacy of montmorillonite clay inclusion in diets. In this study, isotherm analyses showed that carnitine/choline amended montmorillonite clays and acid processed montmorillonite clays (APMs) were effective sorbents for chemicals with diverse structures and properties, including important mycotoxins, i.e. aflatoxin and zearalenone (ZEN) and the hazardous environmental chemicals, i.e. benzo[a]pyrene (BaP), aldicarb, glyphosate and polychlorinated biphenyls (PCBs). A hydra bioassay developed in our laboratory further confirmed the safety of clay inclusion in diets and the protective effects against individual toxins.
Besides decreased expansibility in water, higher surface areas, lower levels of trace metals and enhanced binding capacities of the newly developed clays, the enthalpy results suggested that the adsorption reaction can be classified as a chemisorption, involving tight binding of toxins to clay surfaces. This is the first report of a sorbent (other than activated carbon) with high binding efficacy for these toxins. Also, protection of hydra against a mycotoxin mixture and a PCB mixture indicated that APMs were able to adsorb mixtures of toxins due to high capacities. Based on our results, the carnitine/choline amended montmorillonites and APM clays can be delivered in water, capsules, food, vitamins, etc. as broad-acting toxin enterosorbents for the mitigation of mixtures of hazardous mycotoxins and environmental chemicals
The representation of filial piety in the Yuan-dynasty handscroll Four stories of filial piety
No full textXiao 孝 (filial piety), as the one of the core concepts of Confucianism, has held
profound significance in Chinese society throughout history. However, the idea of filial
piety is not static, instead, it is ever-changing and dynamic. Many Chinese artworks
engage with this subject, and the Yuan-dynasty 元 (1271-1368) handscroll painting Si
Xiao Tu 四孝圖 (Four Stories of Filial Piety) is one of them. Presently collected in the
Taipei National Palace Museum, the pictures of the handscroll render four stories of
filial piety. In its current arrangement, it begins with the narrative of the wife of Wang
Wuzi 王武⼦ of the Tang dynasty 唐 (618-907), and then Lu Ji 陸績 of the Three
Kingdoms period 三國 (220-280), Wang Xiang 王祥 of the Jin dynasty 晉 (266-420) ,
and, at the end, Cao E 曹娥 of the Eastern Han dynasty 東漢 (25-220). Although the
depiction of filial stories can be found in previous funerary art, artworks on this subject
is rare to be put in silk materials. The examination of this handscroll, thus, is
meaningful in studying what this new form of presentation may have conveyed new
messages to its historical audience. This may assist us in investigating the development
of the concept of filial piety and its pictorial traditions, especially under the Mongol
governance in the Yuan era. In particular, it helps us to understand how Chinese literati
endured difficulties in repositioning themselves when facing the shifts of bureaucrat
system. Focusing on the representation of body and pain, I will also try to reconstruct
the formation and function of this handscroll at the time when it was produced.published_or_final_versionArt HistoryMasterMaster of Philosoph
Jinlong capsule inhibits migration and invasion in human glioblastoma cells via the modulation of mTOR/S6 signaling pathway
No full textJingren Shi,1 Wenli Zhang,2 Lu He,2 Fanhong Kong,2 Meichen Pan,1 Jingjing Guo,1 Xinmin Xu,1 Jie Guo,1 Huizhu Wang,1 Yajie Wang11Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, People’s Republic of China; 2Department of Clinical Laboratory, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, People’s Republic of ChinaAim: To investigate the anticancer effects of Jinlong capsule (JLC) against human glioblastoma cells and the possible underlying mechanism.Methods: Cell Counting Kit-8 and colony formation assay were adopted for the analysis of cell viability. Cell invasion and migration were evaluated by transwell and wound healing assays. Then, the expression level of mammalian target of rapamycin (mTOR), phosphorylated mTOR (p-mTOR), S6 and phosphorylated S6 (p-S6) were determined by western blotting.Results: The results showed that JLC significantly inhibited human glioblastoma cell proliferation, invasion and migration in a dose-dependent manner. The expressions of p-mTOR and p-S6 were dramatically suppressed by JLC. Furtherly, inhibition of mTOR reduced the cell migration and invasion, while the mTOR agonist (MHY1485) could partially reverse the anti-migration and anti-invasion activity of JLC.Conclusion: The above results suggested that JLC would be a potential candidate for the treatment of glioblastoma.Keywords: Jinlong capsule, invasion, migration, glioblastoma, mTOR, S6
 
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