52,035 research outputs found
Metadata Representations for Queryable ML Model Zoos
No full textMachine learning (ML) practitioners and organizations are building model zoos of pre-trained models, containing metadata describing properties of the ML models and datasets that are useful for reporting, auditing, reproducibility, and interpretability purposes. The metatada is currently not standardised; its expressivity is limited; and there is no interoperable way to store and query it. Consequently, model search, reuse, comparison, and composition are hindered. In this paper, we advocate for standardized ML model metadata representation and management, proposing a toolkit supported to help practitioners manage and query that metadata.Web Information SystemsHuman-Centred Artificial Intelligenc
A Manifesto of Nodalism
Get PDFThis paper proposes the notion of Nodalism as a means describing contemporary culture and of understanding my own creative practice in electronic music composition. It draws on theories and ideas from Kirby, Bauman, Bourriaud, Deleuze, Guatarri, and Gochenour, to demonstrate how networks of ideas or connectionist neural models of cognitive behaviour can be used to contextualize, understand and become a creative tool for the creation of contemporary electronic music
Optimizing ML Inference Queries Under Constraints
No full textThe proliferation of pre-trained ML models in public Web-based model zoos facilitates the engineering of ML pipelines to address complex inference queries over datasets and streams of unstructured content. Constructing optimal plan for a query is hard, especially when constraints (e.g. accuracy or execution time) must be taken into consideration, and the complexity of the inference query increases. To address this issue, we propose a method for optimizing ML inference queries that selects the most suitable ML models to use, as well as the order in which those models are executed. We formally define the constraint-based ML inference query optimization problem, formulate it as a Mixed Integer Programming (MIP) problem, and develop an optimizer that maximizes accuracy given constraints. This optimizer is capable of navigating a large search space to identify optimal query plans on various model zoos.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Web Information SystemsHuman-Centred Artificial Intelligenc
Systematic reviews with language restrictions and no author contact have lower overall credibility: a methodology study
No full textZhen Wang,1–3 Juan P Brito,4 Apostolos Tsapas,5 Marcio L Griebeler,4 Fares Alahdab,1,3 Mohammad Hassan Murad,1,3,61Robert D and Patricia E Kern Center for the Science of Health Care Delivery, 2Division of Health Care Policy and Research, Department of Health Sciences Research, 3Knowledge and Evaluation Research Unit, 4Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA; 5Aristotle University of Thessaloniki, Thessaloniki, Greece; 6Division of Preventive, Occupational and Aerospace Medicine, Mayo Clinic, Rochester, MN, USABackground: High-quality systematic reviews (SRs) require rigorous approaches to identify, appraise, select, and synthesize research evidence relevant to a specific question. In this study, we evaluated the association between two steps in the conduct of an SR – restricting the search to English, and author contact for missing data – and the overall credibility of a SR.Methods: All SRs cited by the Endocrine Society's Clinical Practice Guidelines published from October 2006 through January 2012 were included. The main outcome was the overall A Measurement Tool to Assess Systematic Reviews (AMSTAR) score, as a surrogate of SR credibility. Nonparametric Kruskal–Wallis tests and multivariable linear regression models were used to investigate the association between language restriction, author contact for missing data, and the overall AMSTAR score.Results: In all, 69 SRs were included in the analysis. Only 31 SRs (45%) reported searching non-English literature, with an average AMSTAR score of 7.90 (standard deviation [SD] =1.64). SRs that reported language restriction received significantly lower AMSTAR scores (mean =5.25, SD =2.32) (P<0.001). Only 30 SRs (43%) reported contacting authors for missing data, and these received, on average, 2.59 more AMSTAR points (SD =1.95) than those who did not (P<0.001). In multivariable analyses, AMSTAR score was significantly correlated with language restriction (beta =-1.31, 95% confidence interval [CI]: -2.62, -0.01, P=0.05) and author contact for missing data (beta =2.16, 95% CI: 0.91, 3.41, P=0.001). However, after adjusting for compliance with reporting guidelines, language restriction was no longer significantly associated with the AMSTAR score.Conclusion: Fewer than half of the SRs conducted to support the clinical practice guidelines we examined reported contacting study authors or searched non–English literature. SRs that did not conduct these two steps had lower quality scores, suggesting the importance of these two steps for overall SR credibility.Keywords: evidence-based medicine, research design, validity, quality of evidenc
Characterization and protein analysis of <i>Ts</i>-ML-EVs.
No full text(A) Morphological characterization of Ts-ML-EVs by TEM. Arrows indicate isolated Ts-ML-EVs. (B) Western blot analysis showing the marker protein of Ts-ML-EVs. (C) SDS-PAGE analyses of purified Ts-ML-EVs using silver-staining.</p
ML-assisted Equalization for 50-Gb/s/λ O-band CWDM Transmission over 100-km SMF
No full textThis dataset supports the publication:
Yang Hong, Stavros Deligiannidis, Natsupa Taengnoi, Kyle R. H. Bottrill, Naresh K. Thipparapu, Yu Wang, Jayanta K. Sahu, David J. Richardson, Charis Mesaritakis, Adonis Bogris, and Periklis Petropoulos
ML-assisted Equalization for 50 Gb/s/λ O-band CWDM Transmission over 100-km SMF
IEEE Journal of Selected Topics in Quantum Electronics
10.1109/JSTQE.2022.3155990</span
Transgenic tomato overexpressing Brassica juncea 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE1 enhances health-promoting vitamin E, carotenoids, squalene and phytosterols
No full textTransgenic tomato overexpressing Brassica juncea 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE1 enhances health-promoting vitamin E, carotenoids, squalene and phytosterols Pan Liao1,2, Xinjian Chen1, Mingfu Wang1, Thomas J. Bach3, Mee-Len Chye1,2* 1School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China. 2Partner State Key Laboratory of Agrobiotechnology (CUHK). 3Centre National de la Recherche Scientifique, UPR 2357, Institut de Biologie Moléculaire des Plantes, 67083 Strasbourg, France. *Corresponding author: [email protected] Isoprenoids consist of a large group of functional natural products. For instance, dietary phytosterols are known to lower blood cholesterol levels. 3-Hydroxy-3-methylglutaryl-coenzyme A synthase (HMGS) is the second enzyme in the mevalonate (MVA) pathway which generate isoprenoids including phytosterols [1,2]. Previous studies on the enzyme kinetics of recombinant wild-type (wt) and mutant Brassica juncea HMGS1 had shown that the HMGS mutant enzyme S359A had a 10-fold higher activity [3]. Furthermore, the overexpression of B. juncea wt and mutant (S359A) BjHMGS1 in Arabidopsis upregulated native HMGR, SMT2, DWF1, CYP710A1 and BR60X2, thereby increasing sterol content [4]. Also, tobacco HMGS-overexpressors (OEs) enhanced native NtHMGR1, NtIPI2, NtSQS, NtSMT1-2, NtSMT2-1, NtSMT2-2 and NtCYP85A1 expression in seedlings, improving sterol content, plant growth and seed yield [5]. When wt and mutant (S359A) BjHMGS1 were overexpressed in a crop plant tomato (Solanum lycopersicum), gas chromatography–mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) results showed that not only did the MVA-derived squalene and sterols, but also the methylerythritol phosphate (MEP)-derived carotenoids and vitamin E (α-tocopherol), increased, revealing crosstalk between the MVA and MEP pathways. Furthermore, OE-S359A fruits displayed greater squalene and phytosterol content than OE-wtBjHMGS1, as a result of higher expression of SlHMGR2, SlFPS1, SlGPS, SlSQS and SlCYP710A11 [6]. In summary, the manipulation of BjHMGS1 represents a promising strategy to simultaneously enhance health-promoting squalene, phytosterols, carotenoids and vitamin E in an edible fruit. This work was supported by the Wilson and Amelia Wong Endowment Fund, Research Grants Council of Hong Kong (AoE/M-05/12), Innovation Technology Fund of the Innovation Technology Commission (Support to Partner State Key Laboratories in Hong Kong) and HKU CRCG awards (0910159039, 1007160002, 1511159010). PL was supported by a University Postgraduate Fellowship and a Postdoctoral Fellowship. 1. Liao P, Hemmerlin A, Bach TJ, Chye ML. Biotechnol Adv, 2016, 34, 697-713. 2. Liao P, Wang H, Hemmerlin A, Nagegowda DA, Bach TJ, Wang M, Chye ML. Plant Cell Rep, 2014, 33, 1005- 1022. 3. Nagegowda DA, Bach TJ, Chye ML. Biochem J, 2004, 383, 517-527. 4. Wang H, Nagegowda DA, Rawat R, Bouvier-Navé P, Guo D, Bach TJ, Chye ML. Plant Biotechnol J, 2012, 10, 31-42. 5. Liao P, Wang H, Wang M, Hsiao AS, Bach TJ, Chye ML. PLoS One, 2014, 9, e98264. 6. Liao P, Chen X, Wang M, Bach TJ, Chye ML. Plant Biotechnol J, 2017, (DOI: 10.1111/pbi.12828)
Bioinformatic analyses of proteins in <i>Ts</i>-ML-EVs.
No full text(A) Gene ontology (GO) annotation of all 753 proteins in Ts-ML-EVs. (B) Protein subcellular localization mapping of proteins.</p
Amolops albispinus Sung, Wang and Wang, sp. nov.
No full textAmolops albispinus Sung, Wang and Wang sp. nov. (Fig. 3 and 4) Holotype: SYS a003454, adult male, collected by Jian Wang, Zu-Yao Liu and Zhi-Tong Lyu on 26 January, 2015 from Mt. Wutong (22°34′54.8″N, 114°12′2.7″E; 260 m a.s.l.), Shenzhen City, Guangdong Province, China. Paratype: 13 adult specimens, collected Ying-Yong Wang, Jian-Huan Yang, Run-Lin Li, Zu-Yao Liu, Jian Wang, and Zhi-Tong Lyu from Mt. Wutong at elevations between 85 – 500 m. Seven males: SYS a003364 by Ying- Yong Wang on 13 January 2012, SYS a001509 by Jian-Huan Yang and Run-Lin Li on 5 March 2012, SYS a003271 and 3272 by Zu-Tao Liu, Jian Wang and Zhi-Tong Lyu on 16 September 2014, SYS a003452 by Jian Wang and Run-Lin Li on 26 January 2015, SYS a003473 by Zu-Yao Liu, Jian Wang and Zhi-Tong Lyu on 13 March 2015, and SYS a004511 by Zhi-Tong Lyu and Jian Wang on 22 October 2015; six females: SYS a001508, 1513, 1514, and 1526 by Ying-Yong Wang, Jian-Huan Yang, Run-Lin Li on 8 March 2012, SYS a003270 by Zu-Yao Liu, Jian Wang and Zhi-Tong Lyu on 16 September 2014, SYS a003453 by Jian Wang and Run-Lin Li on 26 January 2015. Other specimens examined include five juveniles: SYS a001510 collected by Jian-Huan Yang and Run-Lin Li on 5 March 2012, SYS a001532 collected by Jian-Huan Yang and Run-Lin Li on 10 March 2012, and SYS a003474, 3475 and 3481 collected by Jian Wang and Zhi-Tong Lyu on 13 March 2015 from Mt. Wutong. Diagnosis. The presence of an abdominal sucker in the tadpole is the diagnostic character for the genus Amolops (Rao & Wilkinson 2007). However, because the tadpole of the new species remains to be discovered, we assigned the new species to this genus based on the morphological and genetic similarity of the adult specimens to those of A. ricketti and A. wuyiensis. Amolops albispinus sp. nov. is distinguished from its congeners by a combination of the following morphological characteristics: (1) presence of white conical spines on the upper and lower lips, loreal and temporal regions, excluding the tympanum; (2) relatively small body size, SVL 36.1–42.4 mm in adult males and 43.1–50.9 mm in adult females; (3) dorsal skin of body very rough with numerous raised large warts; (4) dorsal body olivebrown with dark brown blotches; (5) presence of strongly developed vomerine teeth; (6) absence of vocal sacs; (7) absence of tarsal glands; (8) absence of the dorsolateral folds; (9) presence of a circummarginal groove on the disk of the first finger; (10) absence of outer metatarsal tubercles. Description of Holotype: Head width approximately equal to head length (HDW/HDL 1.0); snout short (SNT/HDL 0.4) and rounded in profile, projecting beyond lower jaw; nostril closer to tip of snout than eye; loreal region concave; top of head flat; eye large and convex (EYE/HDL 0.3); eye diameter shorter than snout length (EYE/SNT 0.9); canthus rostralis distinct; pineal body barely visible; tympanum small, edge faintly distinct; supratympanic fold broad, from back of eye to shoulder; choanae large; vomerine teeth on well-developed ridges, converging posteriorly; tongue cordiform, deeply notched posteriorly; vocal sacs absent. Forelimbs moderately robust; hands moderately long (ML/SVL 0.3); relative finger lengths I<II<IV<III; finger tips on I–IV dilated to wide oval disks with circummarginal grooves, relative width of finger disks I<II<III=IV; nuptial pad on first finger prominent with strongly developed white conical spines; subarticular tubercles prominent, rounded; inner and outer metacarpal tubercle slightly elongated; no finger webbing or lateral fringes. Hindlimbs long and robust (TIB/SVL 0.5; PL/SVL 0.5); relative toe lengths I<II<V<III<IV; tips of all toes expanded to well-developed oval discs with circummarginal grooves; subarticular tubercles oval and distinct; inner metatarsal tubercles laterally compressed and pronounced; outer metatarsal tubercles absent; toes fully webbed, webbing formula I1–1 II1–2 ¾ III1–3 IV3–1 following Savage (1997); lateral fringe present; tibio-tarsal articulation reaching snout, when hindlimb stretched alongside of body. Skin on dorsal surface of head, trunk, and limbs very rough with numerous tubercles and large raised warts; prominent conical spines on the upper and lower lips, loreal and temporal regions, excluding the tympanum; numerous small tubercles and ridges on the throat and ventral surfaces of trunk and limbs; dorsolateral fold absent; posterior part of upper lip swollen; rictal gland prominent and ellipsoidal, posterior to corner of mouth. Measurement of holotype (in mm). SVL 36.8; HDL 13.2, HDW 13.4; SNT 5.2; IOD 3.3; EYE 4.6; TMP 1.5; TEY 1.3; TIB 17.3; ML 11.4; PL 19.2; F2D 1.8; F3D 2.2; T4D 1.4. Color in life. Dorsal surface olive-brown with raised dark brown blotches on the dorsal surface of head and trunk and small dark brown spots on the dorsal surface of fingers, upper arms, tarsi, tibias, thighs and toes; faint dark transverse bars on dorsal surface of fingers, lower arms, tarsi, tibias, thighs and toes; posterior edge of upper lip and rictal gland copper; white conical spines on upper and lower lips, loreal and temporal regions, excluding tympanum; nuptial pad and spines white; dorsal surfaces of discs on fingers copper; copper flecks on the lateral sides of body; ventral surface of the throat, chest, and belly opaque creamy white, some grey flecks on the throat and chest; ventral surface of the hands and feet dark grey; ventral surfaces of the upper arms, lower arms, tarsi, tibias, and thighs pink with copper flecks; rear of thighs copper with dark mottling. Color in preservative. On dorsum, color fades to dark olive with dark brown blotches, transverse bars, and spots; ventral surface yellow with grey mottling on throat and chest; edge of the ventral surface of the belly with a hint of orange (Fig. 3). Variation. Measurements of type series are given in Table 3. All specimens were very similar in morphology and color pattern. However, the main diagnostic character of this species (i.e., white conical spines on upper and lower lips, temporal and loreal regions), are obvious on adult males but subtle on adult females, which indicates that it is a secondary sexual character. Comparisons. Morphologically, Amolops albispinus sp. nov. differs from A. ricketti, A. wuyiensis, A. daiyunensis, and A. hongkongensis (in parenthesis), to which it is most closely related (Fig. 2), by the presence of white strongly developed conical spines on upper and lower lips and loreal and temporal regions, excluding tympanum (vs. absence; Fig. 3), and by the presence of numerous raised large warts on the dorsal skin of the body (vs. dorsal skin without such warts). Further, it differs from A. ricketti by having a relative small body size at SVL 36.7–42.4 mm in adult males (vs. 42.0–60.5), and 43.1–51.9 mm in adult females (vs. 53.5–67.0), and a dorsal color of olive-brown with dark brown blotches (vs. dorsal color olive-brown or brown with light-colored wormlike marks); from A. wuyiensis by the presence of vomerine teeth (vs. absence), absence of vocal sacs (vs. presence), and white nuptial spines (vs. black); from A. daiyunensis by the presence of vomerine teeth (vs. absence), absence of vocal sacs (vs. presence), prominent conical nuptial spines (vs. fine, particle-like), and absence of tarsal gland (vs. presence); and from A. hongkongensis by the presence of vomerine teeth (vs. absence), absence of vocal sacs (vs. presence), and prominent conical nuptial spines (vs. fine, particle-like). In addition to the presence of white, strongly developed, conical spines on the upper and lower lips and loreal and temporal region, Amolops albispinus sp. nov. differs from the remaining 46 species of Amolops as follows: from A. akhaorum, A. aniqiaoensis, A. archotaphus, A. bellulus, A. chakrataensis, A. chayuensis, A. chunganensis, A. compotrix, A. cremnobatus, A. cucae, A. gerbillus, A. iriodes, A. jaunsari, A. kohimaensis, A. longimanus, A. mengyangensis, A. minutus, A. monticola, A. nyingchiensis, and A. vitrea by the lack of dorsolateral folds (vs. presence); from A. formosus, A. granulosus, A. jinjiangensis, A. kangtingensis, A. liangshanensis, A. lifanensis, A. loloensis, A. mantzorum, A. nidorbellus, A. tuberodepressus, and A. viridimaculatus by the presence of a circummarginal groove on disk of first finger (vs. absence); from A. afghanus, A. assamensis, A. himalayanus, A. indoburmanensis, A. marmoratus, and A. spinapectoralis by the absence of vocal sacs (vs. presence); from A. daorum, A. hainanensis, A panhai, and A. torrentis by the presence of strongly developed vomerine teeth (vs. vomerine teeth weak or absent); from A. caelumnoctis, A. medogensis, and A. splendissimus by a dorsal color of olive-brown with dark brown blotches (vs. dorsal color of green or bright yellow); and from A. larutensis and A. kaulbacki by the absence of outer metatarsal tubercles (vs. presence). Etymology. The specific name, albispinus, refers to the “white spines” on the upper and lower lips, and loreal and temporal regions, which are the diagnostic features of this new species. As an English common name we suggest “White-spined Cascade Frog”. Distribution and ecology. Currently, A. albispinus sp. nov. is known from the type locality of Mt. Wutong, and from Mt. Paiya, which is 30 km from Mt. Wutong, in Shenzhen City, Guangdong Province, China. This species is common in Mt. Wutong throughout the year, whereas, it was observed to be rare in Mt. Paiya (only one specimen (SYS a002436) found). It inhabits low to mid-elevation (60–500 m) rocky, fast-flowing streams surrounding by moist subtropical secondary evergreen broadleaved forests.Published as part of Sung, Yik-Hei, Hu, Ping, Wang, Jian, Liu, Hai-Jun & Wang, Ying-Yong, 2016, A new species of Amolops (Anura: Ranidae) from southern China, pp. 525-538 in Zootaxa 4170 (3) on pages 530-534, DOI: 10.11646/zootaxa.4170.3.6, http://zenodo.org/record/26063
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