852 research outputs found
Do lncRNAs and circRNAs expression profiles influence discoid lupus erythematosus progression?—a comprehensive analysis.
Get PDFBackground: Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs)are involved in the progression of discoid lupus erythematosus (DLE), but an understanding of their underlying mechanisms remains elusive. To explore the expression profiles of lncRNAs and circRNAs in DLE, we surveyed the lncRNA/circRNA and mRNA expression profiles in the epithelia of oral DLE and adjacent normal tissues. Methods: The lesional and non-lesional lower lips of three DLE patients were analysed by RNAsequencing (RNA-seq). The principal functions of the significantly deregulated genes were identified using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. And the correlated expression networks (coding-noncoding co-expression and lncRNAstranscription factor-mRNA) were evaluated as well. Results: Hundreds of significantly changed lncRNAs and mRNAs and dozens of significantly changed circRNAs were identified. lncRNA lnc-MIPOL1-6 and IncRNA IncDDX47-3 expressions were correlated with immune response-related genes, including IL19, CXCL1, CXCL11, and TNFSF15. Up-regulated IncRNA-TF network consists of 8 TFs and 74 related lncRNAs. The lncRNA-TF-gene trans-regulation consisting of 204 lncRNAs,39 TFs, and correlated 3 genes. Conclusions: These results demonstrate that lncRNAs and circRNAs can influence the progression of DLE. Certain mRNAs/lncRNAs/circRNAs may have substantial value in DLE diagnosis and therapy
Supplemental material for Diagnostic determination of <i>Norovirus</i> infection as one of the major causes of infectious diarrhea in HIV patients using a multiplex polymerase chain reaction assay
No full textSupplemental Material for Diagnostic determination of Norovirus infection as one of the major causes of infectious diarrhea in HIV patients using a multiplex polymerase chain reaction assay by Siyuan Yang, Min Li, Jingwei Cheng, Gang Wan, Yunao Zhou, Hongyu Jia, Hongshan Wei, Rui Song, Linjun Sheng, Huizhu Wang, Linghang Wang and Wenhao Hua in International Journal of STD & AIDS</p
Story about two sisters narrated by Wang Min
No full text王林君唱尔苏山歌，歌颂家乡美。Equipment: Mobile phone Chenchong-Z1
Energetics of Electron–Hole Separation at P3HT/PCBM Heterojunctions
No full textThe energetics of electronhole separation at the prototypical donor-acceptor interface P3HT/PCBM is investigated by means of a combination of molecular dynamics simulations, quantum-chemical methods, and classical microelectrostatic calculations. After validation against semiempirical Valence Bond/Hartree-Fock results, microelectrostatic calculations on a large number of electron-hole (e-h) pairs allowed a statistical study of charge separation energetics in realistic morphologies. Results show that charge separation is an energetically favorable process for about 50% of interfacial e-h pairs, which provides a rationale for the high internal quantum efficiencies reported for P3HT/PCBM heterojunctions. Three effects contribute to overcome the Coulomb attraction between electron and hole: (i) favorable electrostatic landscape across the interface, (ii) electronic polarization, and (iii) interface-induced torsional disorder in P3HT chains. Moreover, the energetic disorder due to the PCBM polar group is shown to play a key role in increasing the dissociation probability
Unconventional bulk-Fermi-arc links paired third-order exceptional points splitting from a defective triple point
No full textAbstract Exceptional degeneracies, unique to open systems, are important in non-Hermitian topology. While bulk-Fermi-arcs connecting second-order exceptional points (EP2s) have been observed, the existence of bulk-Fermi-arcs linking higher-order exceptional points remains unexplored. Here, we introduce an unconventional bulk-Fermi-arc in systems with parity-time and pseudo-Hermitian symmetries, which links paired third-order exceptional points (EP3s), where three eigenvalues share identical real parts but distinct imaginary parts. We realize these systems using topological circuits and experimentally demonstrate this unconventional bulk-Fermi-arc. A winding number defined from resultant vector shows that the bulk-Fermi-arc is stabilized by the exchange of Riemannian sheets. Furthermore, analysis via eigenframe deformation and rotation reveals that the EP3 pair is topologically nontrivial and equivalent to a single defective triple point. The EP3s can split from the triple point by varying system parameters, with this splitting protected by topological equivalence. This finding offers insights into non-Hermitian topology with potential applications in wave engineering
Detailed Facade Reconstruction for Mahattan-world Buildings
No full text3D building models play an important role in many real-world applications. Different models are suitable for different application scenarios based on their levels of detail. LOD3 models with facade details are crucial for many applications, such as virtual reality and urban simulation. Currently, 3D building models with lower LOD are largely available, but the number of LOD3 models is very limited. Most LOD3 reconstruction methods depend on manual operation, which is very time-consuming. How to automatically reconstruct the detailed facade for building models has remained a problem in computer vision. The problem can be seen as an image processing problem, but how to convert the 2D results into 3D smoothly should also be considered. In this project, we proposed a method to automatically reconstruct the detailed building models based on the Faster R-CNN. The method starts from a set of street view images, and the results are models with facade elements. A 3D point cloud can be extracted from the images using SfM and MVS, and the camera parameters can also be recovered. We take advantage of the high-quality facade images and parse the facades to detect their bounding boxes. The bounding boxes can match pretty well with the rectangular shape of the facade elements. The 2D facade elements can be added to the 3D building model based on the camera parameters. The process is very efficient and automatic. The regularity of the facade elements will be reserved, making the result more convincing. Our method includes four main steps: (1) coarse model reconstruction, (2) facade image selection and rectification, (3) facade element detection and regularization, and (4) detailed facade reconstruction. Experiment results show that our method can produce reliable building models with facade details for many different situations. It can work for both the multi-face building blocks and the street side buildings. Our test shows that the window detection performance is pretty good. The object detection is extremely fast, and the whole pipeline is lightweight and efficient. In theory, the method can also be extended to reconstruct large-scale city models, which means it has broad application prospects.Geomatic
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A framework for natural disaster memorial park design 5/12 Earthquake Memorial Park design
Get PDFAn earthquake with a magnitude of 8.0 on the Richter scale rocked Sichuan on May 12, 2008, eventually claiming 69,227 lives, and 374,643 injured. The quake toppled houses and schools, virtually destroying entire villages, and irreparably changed everyone's world there. The quake severely affected an estimated 45,547,565 residents in Sichuan province, damaged approximately 4,300,000 structures, and destroyed buildings including homes, businesses, schools, and hospitals. Thousands of innocent people lost their precious lives in this disaster. Among these people, there were young students reading out beautiful poems in books; there were mamas preparing hot milk for their kids in the morning; there were...however, those bright lives, at that moment, all became cold numbers in the history books. A natural disaster memorial park is needed to memorialize all the survivors and victims of this great disaster, to tell stories of survival and loss, to encourage people surmounting the tragedy bravely, and to provide a refuge for future disasters. Throughout the research conducted after the May 12 earthquake, the author has observed that no integrated system of planning and design has been established in natural disaster memorial park design. The thesis defines the conception of a memorial landscape and natural disaster memorial park, reviews the history of natural disaster memorial parks, and sorts through many cases of memorial parks. A general design guideline and theory for natural disaster memorial park design will be summarized from case studies, and this guideline will be interpreted particularly in terms of the 5/12 Earthquake Memorial Park design in China. The result of this research is an extension of an overall knowledge base and a theory explaining the difference between "natural disaster memorials" and "war memorials" design and summarizing the basic elements that constitute the physical and psychological characteristics of natural disaster memorial park design. The 5/12 Earthquake Memorial design will be a new application of the integration of the new theory about Natural Disaster Memorial Landscape design and will provide guidance and reference for park planners and designers to promote multiple functions in memorial park design in the future
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