285 research outputs found
Code for the mQTL analyses in 2023 Nature Genetics
No full textCitation:
Analysis of blood methylation quantitative trait loci in East Asians identifies ancestry-specific effects associated with complex trait variation.
Qianqian Peng, Xinxuan Liu, Wenran Li, Han Jing, Jiarui Li, Xingjian Gao, Qi Luo, Charles E. Breeze, Siyu Pan, Qiwen Zheng, Guochao Li, Jiaqiang Qian, Liyun Yuan, Na Yuan, Chenglong You, Siyuan Du, Yuanting Zheng, Ziyu Yuan, Jingze Tan, Peilin Jia, Jiucun Wang, Guoqing Zhang, Xianping Lu, Leming Shi, Shicheng Guo, Yun Liu, Ting Ni, Bo Wen, Changqing Zeng, Li Jin, Andrew E. Teschendorff, Fan Liu, Sijia Wang
Emerging Trends and Technologies in the Information Ecosystem, May 13, 2022
No full textPresentations: "Improving Low Morale in Academic Libraries" by Teva Sweet; "Digital Images and Printing" by Jessica LemingMay’s Emerging Trends presentations provided tips on using technology for the creation and delivery of information. Teva Sweet presented "Improving Low Morale in Academic Libraries" and Jessica Leming discussed "Digital Images and Printing.” Teva’s presentation covered the following topics: outcomes of low morale; retention; institutional credibility; and shareholder satisfaction. She offered some ways to improve low morale at academic libraries. Some examples are: taking the time to know co-workers, create community, do climate surveys, and focus on work/life balance. In Jessica’s presentation, she discussed assisting researchers and scholars in digital images and printing. She covered standard PPI, TIFF vs JPEG, dye sublimation printing, and print quality for different printers and paper
Spreading the Word: New Collections at the Atlanta University Center, 2018
No full textThe Archives Research Center at Atlanta University Centers Robert W. Woodruff Library is pleased to announce the accessibility of fourteen collections of rare materials that document African American religion spanning from the 1880s to the 2000s. These unique collections include correspondence, sermons and speeches, research files, photographs, and audio and video recordings. The collections document theologians and scholars, as well as Christian and Islamic ideologies. They were donated by educators and family that understood the importance of keeping the materials close to the community from where they were generated. Thanks to a generous grant from the National Endowment for the Humanities, entitled Spreading the Word: Expanding Access to African-American Religious Archival Collections of the Atlanta University Center Robert W. Woodruff Library, the Librarys Archives Research Center and Digital Services Unit have digitized over 2,700 photographs, cassettes, and reel to reel audio and video formats. The grant team prioritized these audio and video collections due to the inherent instability of magnetic media and the decreasing availability of playback equipment, a situation archives all over the country are currently facing
The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies
No full textReproducibility is a fundamental requirement in scientific experiments and clinical contexts. Recent publications raise concerns about the reliability of microarray technology because of the apparent lack of agreement between lists of differentially expressed genes (DEGs). In this study we demonstrate that (1) such discordance may stem from ranking and selecting DEGs solely by statistical significance (P) derived from widely used simple t-tests; (2) when fold change (FC) is used as the ranking criterion, the lists become much more reproducible, especially when fewer genes are selected; and (3) the instability of short DEG lists based on P cutoffs is an expected mathematical consequence of the high variability of the t-values. We recommend the use of FC ranking plus a non-stringent P cutoff as a baseline practice in order to generate more reproducible DEG lists. The FC criterion enhances reproducibility while the P criterion balances sensitivity and specificity
Highly Enantioselective Aza-Michael Reaction between Alkyl Amines and beta-Trifluoromethyl beta-Aryl Nitroolefins
No full textThe aza-Michael addition reaction is a vital transformation for the synthesis of functionalized chiral amines. Despite intensive research, enantioselective aza-Michael reactions with alkyl amines as the nitrogen donor have not been successful. We report the use of chiral N-heterocyclic carbenes (NHCs) as noncovalent organocatalysts to promote a highly selective aza-Michael reaction between primary alkyl amines and beta-trifluoromethyl beta-aryl nitroolefins. In contrast to classical conjugate-addition reactions, a strategy of HOMO-raising activation was used. Chiral trifluoromethylated amines were synthesized in high yield (up to 99%) with excellent enantioselectivity (up to 98% ee).National Natural Science Foundation of China [21372013, 21572004]; Shenzhen Peacock Program [KQTD201103]; MOE within the Program for New Century Excellent Talents in UniversitySCI(E)[email protected]
Enantioselective beta-Protonation of Enals via a Shuttling Strategy
No full textRemote asymmetric protonation is a long-standing challenge due to the small size of protons. Reactions involving electron-deficient olefins pose a further difficulty due to the electrophilic nature of these substrates. We report a shuttling system that delivers a proton in a highly enantioselective manner to the beta-carbon of enals using a chiral N-heterocyclic carbene (NHC) catalyst. Choices of a Bronsted base shuttle and a Bronsted acid cocatalyst are critical for highly stereoselective beta-protonation of the homoenolate intermediate and regeneration of the NHC catalyst results in functionalization of the carbonyl group. Thioesters with a beta-chiral center were prepared in a redox-neutral transformation with an excellent yield and ee.National Natural Science Foundation of China [21572004, 21602007]; China Postdoctoral Science Foundation [2016M590009]; Guangdong Province Special Branch Program [2014TX01R111]; Shenzhen Basic Research Program [JCYJ20160226105602871]SCI(E)ARTICLE207045-705113
The feasibility of utilizing remotely sensed data to assess and monitor oceanic gamefish
No full textThere are no author-identified significant results in this report
Acquisitions Driven by Stock Overvaluation
No full textOvervaluation might drive a firm to use its stock to acquire another firm whose stock is not as overpriced. Though hypothetically desirable, these acquisitions create little, if any, value for acquirer shareholders. Two factors impede value creation for acquirer stockholders from these transactions (despite large differences in relative overvaluation at announcement): acquirers paying large premiums to targets, and investors’ correction of acquirer overvaluation during the bid period. Furthermore, acquirer CEOs obtain a large amount of new stock and option grants after acquisitions and realize a net gain in wealth, further suggesting that equity overvaluation increases agency costs and the resulting actions benefit managers more than shareholders (Jensen (2005))
Causes and Penalties of Variation - A Case Study of a Concrete Slab Prefabrication Shop.
No full textHydration Mechanism of Portland Cement Prepared from Stonecoal Vanadium Slag
No full textAbstractThis paper presents an objective study on the utilization of stone coal vanadium slag in preparing cement clinker. The hydrates and hydration mechanism of this cement were analyzed and studied by means of the hydration heat analysis, X-ray diffraction (XRD) and the differential thermal gravity (DTG) analysis. The results of experiments show that the hydration mechanism is similar to ordinary Portland cement. The hydration process can be divided into five stages: (I) initial period; (II) induction period; (III) acceleration period; (IV) deceleration period; (V) final period And the hydrates are basically the same as Portland cement, mainly containing the calcium silicate hydrates (C-S-H), ettringite (AFt), portlandite (CH). It is proved that stone coal vanadium slag can be used as siliceous materials to prepare cement clinker Furthermore, the addition of fine materials such as the waste and fly ash can accelerate cement hydration, which is the result of giving rise to water-to-cementitious ratio. On the other hand, the fine materials may provide the crystal nucleus for hydrates such as portlandite. Using the waste and fly ash to replace part of clinker can prepare series of cement, whose compositions and physical properties are fully complied with the requirements of national standard, and bring huge ecological and economic benefits
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