1,470 research outputs found
A Street-Level IP Geolocation Method Based on Delay-Distance Correlation and Multilayered Common Routers
No full textStructure, function and regulation of drug/xenobiotic transporter
No full textOrganic anion transporters (OATs), as one group of the important Drug/xenobitic transporters, play vital roles in the body disposition of environmental toxins and clinically anionic drugs. Numerous works have forged an extensive framework on OATs. However, more works are required to explore the functionally critical amino acid residues and motifs to glean comprehensive information on relationship between structure and function. In the first part of the thesis, we investigated the role of dileucine (L6L7) at the amino terminus of hOAT1 and GXXXG motifs in its transmembrane domains 2 (G144XXXG148) and 5 (G223XXXG227) of hOAT1 in the expression and function of the transporter by using mutants made by site-directed mutagenesis approach. Mutant transporter L6A/L7A, G144A and G148A showed no transport activity due to its complete loss of surface expression. Proteasomal inhibitor and lysosomal inhibitor treatment suggested the mutant L6A/L7A- G144A- and G148A transporters were degraded through proteasomal pathway. Treatment of L6A/L7A- expressing cells with two chemical chaperones could not repair the misfolding of the mutant transporter in Endoplasmic Reticulum. For mutant transporters G223A and G227A, only G227 showed dramatic reduced transport activity due to dramatic loss in expression. Proteasomal or lysosomal inhibitors resulted in partial recovery of total cell expression of the mutant G227A hOAT1, but not recovery of surface expression and function. Our data suggest that the L6L7 and GXXXG motifs in transmembrane domains 2 and 5 play critical roles in the stability of hOAT1. Our lab has reported that activation of protein kinase C (PKC) leads to accelerated internalization of hOAT1. However the underlying mechanism is still unclear. In the second part of the thesis, we indentified that ubiquitination of hOAT1 was significantly increased after PKC activation by phorbol 12-myristate 13-acetate (PMA) and Angiotensin II (AngII). And the PKC-induced ubiquitination of a mutant N5KR carrying multiple lysine substitutions was abolished. Importantly, cell surface biotinylation experiments showed that the N5KR mutant which has the minimal ubiquitination counteracted against the enhanced retrieval and accelerated degradation of surface hOAT1 proteins by PKC activation, which established a strong correlation of PKC-dependent endocytosis and PKC-dependent ubiquitination of hOAT1.M.S.Includes bibliographical referencesby Jinwei W
Reversible temperature regulation of electrical and thermal conductivity using liquid–solid phase transitions
No full textReversible temperature tuning of electrical and thermal conductivities of materials is of interest for many applications, including seasonal regulation of building temperature, thermal storage and sensors. Here we introduce a general strategy to achieve large contrasts in electrical and thermal conductivities using first-order phase transitions in percolated composite materials. Internal stress generated during a phase transition modulates the electrical and thermal contact resistances, leading to large contrasts in the electrical and thermal conductivities at the phase transition temperature. With graphite/hexadecane suspensions, the electrical conductivity changes 2 orders of magnitude and the thermal conductivity varies up to 3.2 times near 18 °C. The generality of the approach is also demonstrated in other materials such as graphite/water and carbon nanotube/hexadecane suspensions.National Science Foundation (U.S.) (Grant CBET-0755825)National Science Foundation (U.S.) (Grant CTS-0506830
sj-docx-1-cpc-10.1177_10556656211044396 - Supplemental material for Dynamic Change in Oral Microbiota of Children With Cleft Lip and Palate After Alveolar Bone Grafting
No full textSupplemental material, sj-docx-1-cpc-10.1177_10556656211044396 for Dynamic Change in Oral Microbiota of Children With Cleft Lip and Palate After Alveolar Bone Grafting by Kejia Zhang, Xuan Zhou, Jinwei Qin, Weibing Zhang, Yongchu Pan, Hua Wang, Jiuxiang Lin, Luwei Liu and Yilin Jia in The Cleft Palate-Craniofacial Journal</p
Heat conduction mechanisms in nanofluids and suspensions
Full text linkNanofluids, liquids containing suspensions of nanoparticles, have been reported by some groups to exhibit substantially higher thermal conductivity than that of their corresponding base fluids that cannot be explained by existing theories. However, the reported high thermal conductivity sometimes cannot be reproduced by others. Potential mechanisms leading to this enhancement are still under scrutiny. In this paper, we first take a critical review of heat conduction mechanisms proposed in literature, and then summarize our work. Our experimental studies demonstrate that nanoparticle clustering is the key contributor to the thermal conductivity enhancement. Guided by this insight, we use graphite flakes as additives and develop a method to prepare stable graphite suspensions with large thermal conductivity enhancement in water and oil. We also observe thermal percolation phenomenon and explained the phenomenon based on combined optical and AC impedance spectroscopy studies. We demonstrate temperature regulation of electrical and thermal properties of graphite suspensions through solid–liquid phase change, which may potentially be useful in energy systems in the future.United States. Air Force Office of Scientific Research (AFOSR FA9550-11-1-0174)China. Fundamental Research Funds for the Central Universitie
Thliptoceras formosanum Munroe & Mutuura 1968
No full text<i>Thliptoceras formosanum</i> Munroe & Mutuura, 1968 <p>Figs. 5</p> <p> <i>Thliptoceras formosanum</i> Munroe & Mutuura, 1968: 861. Type locality: China, Taiwan, Urai.</p> <p> <b>DIagnosIs.</b> Wing expanse 18–24 mm. <i>Thliptoceras formosanum</i> has the narrow, modified wings of the <i>artatalis</i> group in the male, of dark, greyish fuscous colour, and somewhat paler, more yellowish in the female. It is characterized by a strongly modified male antenna: scape enlarged, base of flagellum enlarged and complex, with large, dorsal fan-shaped scale tuft arranged in a semicircle dorsally of a small depression bordered by two triangular teeth and filled with very small setae, next few segments strongly widened and compressed, curved to form a large shallow sinus. In the male genitalia, this species can be recognized by the claw-shaped sacculus process and the gently concave costa without excavation or spine. In the female genitalia, the weakly sclerotized posterior part of the ductus bursae with an ovate expansion at its base is diagnostic.</p> <p> <b>MaterIal examIned.</b> CHINA, Fujian: 1 ♂, Maodi, Nanping County, alt. 850 m, 22.IX.2002, coll. Wang Xinpu (NKUM); 1 ♂, Xiaobeimen, Fuzhou, 15–16.V.1933; 1 ♂, Daiyuncun, Mt. Daiyunshan, alt. 902 m, 23.V.2012, coll. Li Jinwei; Jiangxi: 1 ♂, Xiagongtang, Mt. Jiulianshan, alt. 630 m, 28.VIII.2007, coll. Zhang Dandan; 1 ♂, Daqiutian, Mt. Jiulianshan, alt. 500 m, 31.VIII.2007, coll. Zhang Dandan; Guangdong: 1 ♂, Heshan County, 10.X.2002, coll. Liu Guilin; 1 ♂, Kau-lin San. Lien-Ping Distr., alt. 700–900m, 23.IV.1940, coll. J. L. Gressitt and F. Z. To.; 1 ♂, Mt. Wutongshan, Shenzhen, 15.IX.1999, coll. Jia Fenglong; 1 ♂, Yangmei, Gaoming County, 23.IV.2006, coll. Zhang Dandan; 1 ♂, Mt. Nankunshan, 16.VII.2003, coll. Zhang Dandan and Li Zhiqiang; 7 ♂, Niupoling, Yangchun County, 18–19.VIII.2009, coll. He Fengxia and Han Xiaolei; 3 ♂, Mt. Heishiding, Fengkai County, 16.VI.2009, 1.V., 5.X.2011, coll. Zhang Dandan, He Fengxia and Tong Bo et. al.; 5 ♂, Mt. Danxiashan, alt. 96 m, 6–7.VI.2012, coll. Li Jinwei; Guangxi: 1 ♂, Mt. Pinglongshan, Shangsi County, alt. 510 m, 6.IV.2002, coll. Hao Shulian and Xue Huaijun (NKUM); 1 ♂, Nonggang, Longzhou County, alt. 271 m, 19.IV.2012, coll. Li Jinwei; Guizhou: 3 ♂, Maolan reserve, 1.IX.2011, coll. Li Jinwei.</p> <p> <b>DIstrIbutIon</b>. China (Fujian, Jiangxi, Guangdong, Guangxi, Guizhou, Taiwan).</p>Published as part of <i>Zhang, Dandan, Xu, Jiawen & Li, Jinwei, 2014, Review of the genus Thliptoceras Warren, 1890 (Lepidoptera: Crambidae: Pyraustinae) from the Oriental region of China, pp. 265-286 in Zootaxa 3796 (2)</i> on pages 268-269, DOI: 10.11646/zootaxa.3796.2.3, <a href="http://zenodo.org/record/230569">http://zenodo.org/record/230569</a>
Thliptoceras sinense Caradja 1925
No full textThliptoceras sinense (Caradja, 1925) Figs. 12, 24, 25, 36, 43 Phlyctaenodes decoloralis sinense Caradja, 1925: 105. Type locality: China, Shanghai; Lienping. Thliptoceras sinense: Munroe, 1967: 723. DIagnosIs. Wing expanse 24–27 mm. Thliptoceras sinense can be recognized in the male by the modified scales along the posterior margin of the forewing and by a modified antenna with a globular scape, a broadened flagellum with a deep, transverse groove at base ending laterally in an upcurved tooth and delineated distally by a transverse ridge covered with raised appressed scales, followed by several compressed and decreasingly widened segments. Male genitalia with valva gradually widening, widest at 2 / 3, costa straight with a minute spine at apex, ventral margin sinuate, editum short and stout, sacculus process triangular, with sparse seatae, juxta with dorso-medial finger-shaped carina, aedeagus with four groups of cornuti of different length and width near distal end. Female genitalia with antrum sclerotised, irregularly tubular with middle part globularly inflated and thick-walled, posterior margin bilobed; ductus bursae long (length about 8 times diameter of corpus bursae), irregularly spiraled, with scattering of minute spinules in widened posteriormost part; signum small (less than half diameter of corpus bursae). MaterIal examIned. CHINA, Zhejiang: 4 ♂, Chanyuansi, Mt. Tianmushan, alt. 350 m, 15.VIII. 1999, coll. Li Houhun (NKUM); 8 ♂, Houshanmen, Mt. Tianmushan, alt. 500 m, 16.VIII. 1999, coll. Li Houhun (NKUM); Fujian: 1 ♂, Mt. Wuyishan, alt. 759 m, 21.V. 2012, coll. Li Jinwei; Jiangxi: 3 ♂, Daqiutian, Mt. Jiulianshan, alt. 500 m, 30.VIII. 2007, coll. Zhang Dandan, 13.VII. 2008, He Fengxia and Li Jiahui; 3 ♂, Fengxin County, alt. 506 m, 22.IX. 2012, coll. Li Jinwei; 2 ♂, Mt. Jinggangshan, 25.IV. 2011, coll. Mei Yan, 30.VI. 2011, coll. Yang Lijun; Guangdong: 4 ♂, 4 ♀, Mt. Danxiashan, alt. 96 m, 17.IV., 31. V., 1.VI. 2008, coll. He Fengxia, 6–7.VI. 2012, coll. Li Jinwei; 1 ♀, Lianping County, 12.VIII. 2009, coll. Zeng Yanyi; 1 ♂, Yanshuitian, Mt. Heishiding, Fengkai County, 2.V. 2011, coll. Zhang Dandan and Tong Bo; Guangxi: 3 ♂, 1 ♀, Gaozhai, Xing’an County, alt. 469 m, 28.VIII. 2011, coll. Zhang Dandan and Yang Lijun; Hainan: 1 ♂, Mt. Limushan, 5.V. 2011, coll. Zhang Dandan and Yang Lijun; Guizhou: 2 ♂, Suoluo, Chishui County, alt. 390 m, 27.V. 2000, coll. Du Yanli (NKUM); 1 ♂, 1 ♀, Suoluo, Chishui County, alt. 240 m, 22.IX. 2000, coll. Yu Haili (NKUM). DIstrIbutIon. China (Shanghai, Zhejiang, Fujian, Jiangxi, Guangdong, Guangxi, Hainan, Guizhou). Remarks. This species was recorded by Song (2001) and Wang et. al. (2003) from Jiangsu, Fujian, Zhejiang and Hainan, China as T. amamiale (Munroe & Mutuura, 1968). In this study, we re-identified this species. Therefore, T. amamiale is not present in China.Published as part of Zhang, Dandan, Xu, Jiawen & Li, Jinwei, 2014, Review of the genus Thliptoceras Warren, 1890 (Lepidoptera: Crambidae: Pyraustinae) from the Oriental region of China, pp. 265-286 in Zootaxa 3796 (2) on page 274, DOI: 10.11646/zootaxa.3796.2.3, http://zenodo.org/record/23056
[ARTICLES] How Curatorial Activities of Exhibitions Are Legitimized: The Case of Japan's Galleries and Museums
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