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Supplemental Material - Does high-speed railway affect the cost behavior of tourism firms? Evidence from China
No full textSupplemental Material for Does high-speed railway affect the cost behavior of tourism firms? Evidence from China by Fangjun Wang, Lizhu Ma, Baojun Gao and Yang Stephanie Liu in Tourism Economics</p
Female board directorships and related party transactions
No full textUsing a sample of Chinese firms from 2005 to 2018, we show that firms with female directors (either executive or independent) are characterised by fewer related party transactions (RPTs), particularly in state-owned enterprises (SOEs). Fewer RPTs are associated with improved subsequent operating performance and, in contrast, RPTs are associated with decreased performance for firms with no or fewer female directors, suggesting that female directors engage or allow only efficient but not opportunistic RPTs to facilitate the long-term strategic objectives of their firms. Our findings are robust for using an alternative measure of RPTs, female board directorships and methods to mitigate potential endogeneity issues
Synthesis, Structure, Magnetism and Electrochemical Properties of Linear Pentanuclear Complex: Ni-5(mu-dmpzda)(4)(NCS)(2)
No full textIntelligent planning for refractive surgeries : a modelling and visualisation-based approach
No full textLaser refractive surgeries have been commonly used in ophthalmic operations. Considerable research has been carried out and encouraging progress made in recent years. It covers properties of the cornea and behaviour of tissue in different parts of the eye, topography and material expression of individual patient's eyes, prediction using finite element (FE) analysis to estimate the corneal shape change and the change in refractive power. Further effort is still required to advance the research to aid the decision making for laser refractive surgeries. This study comprehensively reviews the latest techniques of refractive surgery and research on computational analysis and modelling techniques and their applications, especially the current prediction and planning techniques for laser refractive surgeries. The aim of this study is to develop an intelligent assistant tool for the laser refractive surgeries with prediction and visualisation functions. For this aim, two objectives will be achieved: prediction with the clinical dataset and human vision simulation. Due to clinical statistics, the clinical dataset is often incomplete, imbalanced, and sparse. Three methods are proposed to predict surgery parameters and ... (continues
Effect of Dexmedetomidine on the ED50 and ED95 of Sufentanil in Patient-Controlled Intravenous Analgesia After Cesarean Section: A Randomized, Controlled, Double-Blind Trial
No full textJiabei Li,1,2 Wuchang Fu,3 Na Wang,1 Sisi Zeng,1 Xuechao Li,1 Jixiang Wan,1 Fangjun Wang1 1Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, People’s Republic of China; 2Department of Anesthesiology, Meishan City People’s Hospital, Meishan, People’s Republic of China; 3Department of Anesthesiology, The Second Clinical Medical College of North Sichuan Medical College (Nanchong Central Hospital), Nanchong, People’s Republic of ChinaCorrespondence: Fangjun Wang, Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan South Road, Nanchong, Sichuan, 637000, People’s Republic of China, Tel +86 13458253172, Email [email protected]: To determine the effect of dexmedetomidine on the ED50 and ED95 of sufentanil in patient-controlled intravenous analgesia (PCIA) after cesarean section.Patients and Methods: Parturients who underwent elective cesarean section (n = 80) were randomly assigned to either the sufentanil group (S group) or the dexmedetomidine-sufentanil combination group (DS group). Patients in the S group received a combination of sufentanil, 5 mg of tropisetron, and saline, whereas patients in the DS group were administered 1.5μg/kg of dexmedetomidine in addition to sufentanil, 5 mg of tropisetron, and saline. The ED50 and ED95 of sufentanil were determined by Dixon sequential method. We used probit regression to calculate the ED50, ED95, and 95% confidence intervals for sufentanil in each group.Results: The ED50 and ED95 for sufentanil in the S group were 1.634 (95% CI: 1.476– 1.810)μg/kg and 2.035 (95% CI: 1.841– 3.312)μg/kg, respectively. The ED50 and ED95 for sufentanil in the DS group were 1.275 (95% CI: 1.187– 1.353)μg/kg and 1.503 (95% CI: 1.406– 1.824)μg/kg. The VAS scores with rest at t5 and with movement at t4- t5 were lower in the DS group (P< 0.05). The t2-t5 Ramsay scores in the DS group were higher than those in the S group (P< 0.05). The doses of sufentanil and tramadol were markedly reduced in the DS group, while the onset of first lactation occurred significantly earlier in the DS group (P< 0.05). Compared with the S group, the DS group had a lower incidence of nausea, vomiting, and skin itching (P< 0.05), and lower frequency of patient-controlled analgesia (PCA) episodes (P< 0.05), and better postoperative pain satisfaction (P< 0.05).Conclusion: The 1.5μg/kg dexmedetomidine can significantly decrease the ED50 and ED95 of sufentanil in patient-controlled intravenous analgesia after cesarean section, provide good postoperative analgesia and sedation, and promote the earlier occurrence of first lactation.Keywords: dexmedetomidine, sufentanil, cesarean section, postoperative analgesia, ED50, ED9
Development of Polymer-Based Hydrophobic Monolithic Columns and Their Applications in Proteome Analysis
No full textOnline Sample Injection and Multidimensional Chromatography Separation by Using Strong-Cation Exchange Monolithic Column
No full textLarge-Scale Proteome and Phosphoproteome Quantification by Using Dimethylation Isotope Labeling
No full textAbstract LB-288: An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED
No full textAbstract
Polycomb repressive complex 2 (PRC2) consists of three core subunits, EZH2, EED and SUZ12 and plays pivotal roles in transcriptional regulation through its histone H3K27 methyltransferase activity. Dysregulation of PRC2 is observed in multiple human cancers, for example, the catalytic subunit EZH2 is overexpressed in a wide range of human cancers and gain-of-function mutations of EZH2 within its catalytic site have been reported in human B-cell lymphoma, parathyroid carcinoma and melanoma. Small molecule inhibitors that compete with the cofactor S-adenosylmethionine (SAM) have been reported and showed anti-lymphoma efficacy in pre-clinical studies. EED within the PRC2 complex allosterically activate the enzymatic activity by binding to tri-methylated H3K27 (H3K27me3). Here we report the discovery of EED226, a potent and selective PRC2 inhibitor directly binding to the H3K27me3 binding pocket of EED. EED226 induces conformational change upon binding EED leading to loss of PRC2 activity. EED226 shows similar activity as SAM-competitive inhibitors in blocking H3K27 methylation of PRC2 target genes and inducing regression of human lymphoma xenograft tumors. Interestingly, EED226 also effectively inhibits PRC2 containing mutant EZH2 protein resistant to SAM-competitive inhibitors. Together, we show EED226 inhibits PRC2 activity via an allosteric mechanism and offers opportunity for treatment of PRC2-dependent cancers.
Citation Format: Wei Qi, Kehao Zhao, Justin Gu, Ying Huang, Youzhen Wang, Hailong Zhang, Man Zhang, Jeff Zhang, Zhengtian Yu, Ling Li, Lin Teng, Shannon Chuai, Chao Zhang, Mengxi Zhao, HoMan Chan, Zijun Chen, Douglas Fang, Fei Qi, Leying Feng, Lijian Feng, Yuan Gao, Hui Ge, Xinjian Ge, Andreas Lingel, Guobin Li, Ying Lin, Yueqin Liu, Fangjun Luo, Minlong Shi, Long Wang, Zhaofu Wang, Yanyan Yu, Jue Zeng, Chenhui Zeng, Lijun Zhang, Qiong Zhang, Shaolian Zhou, Counde Oyang, Peter Atadja, En Li. An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr LB-288. doi:10.1158/1538-7445.AM2017-LB-288</jats:p
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