33 research outputs found
CD8"+, CD57"+ lymphocytes A functional and phenotypic analysis in normal peripheral blood
No full textSIGLEAvailable from British Library Document Supply Centre-DSC:D063627 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
The role of death receptor 3 in inflammatory arthritis
No full textThis paper looks at the effects of dust allergen and LPS concentrations on biomarkers of asthma in adults with house dust mite-sensitive asthma
PRM54 Usefulness of a Commercial Hospital Claims Database to Identify Current Anti-Vascular Endothelial Growth Factor Treatment Patterns in Patients with Exudative Age-Related Macular Degeneration in Japan
No full text
Human Cytomegalovirus Infection Downregulates Expression of the Cellular Aminopeptidases CD10 and CD13
No full textAbstractDuring the course of a productive infection, human cytomegalovirus (HCMV) has a sophisticated relationship with its host cell. An increasing number of virus-encoded genes are being identified which act specifically to usurp or modulate functions in the host cell associated with transcriptional control, cell signalling, and protein synthesis. While HCMV infection is associated with a general upregulation of cellular gene expression, the expression a small subset of cellular proteins, including the MHC-1 heavy chain and fibronectin, is downregulated. This study now identifies two additional cellular proteins, aminopeptidase N (CD13) and neutral endopeptidase (CD10), that are downregulated during HCMV infection. While aminopeptidase N and neutral endopeptidase exhibit no significant sequence homology, both are expressed on the cell surface and have very similar enzymatic properties. HCMV infection was associated with reduced surface expression and enzyme activity of CD13 and CD10, an apparent decrease in the rate of synthesis of both proteins in metabolic-labelling experiments, and inhibited glycosylation of the nascent CD13 and CD10 polypeptide chains that were synthesized. Levels of CD10 poly A+RNA were suppressed efficiently at all stages of virus infection; however, the reduction in CD13 poly A+RNA levels was much less pronounced. This differential effect suggests that HCMV may be downregulating expression of CD10 and CD13 by independent mechanisms. Indeed, treatment of cells with an inhibitor of viral DNA synthesis blocks downregulation of CD13, whilst downregulation of CD10 is unaffected. While it is not yet clear what advantage is bestowed on the virus by downregulating expression of CD13 and CD10, aminopeptidases are known to have a role in peptide processing in both the MHC class I the MHC class II antigen presentation pathways
PIH76 Clinical, Humanistic, and Economic Burden of Menstrual Symptoms in Japanese Women
No full textPRM223 Implementation of patient-reported outcomes assessment in a post marketing safety surveillance: Parallels in japan and global planning
No full textVariations in attitudinal gender preferences for children across 50 less-developed countries
No full textWhile a number of studies have examined gender preferences for children by studying behavioral measures, such as skewed sex ratios, sex imbalance in infant mortality, and sibling size/order; attitudinal measures have been analyzed less systematically. Using 50 Demographic and Health Surveys conducted between 2000 and 2008, this paper seeks to advance our understanding of gender preferences in developing countries by examining attitudinal measures cross-nationally. This study’s findings show that, while balance preference is the most common type of preference in the vast majority of countries, countries/regions vary in the prevalence of son and daughter preferences. A preference for sons is not always found; and, indeed, a preference for daughters is shown to prevail in many societies.comparative, cross-national, gender preferences for children
