4,525 research outputs found
Effects of SSRIs on inflammatory markers in patients with major depressive disorder:: a systematic review and meta-analysis
No full textIntroduction: Peripheral levels of inflammatory markers are elevated in major depressive disorder (MDD).Selective serotonin reuptake inhibitors (SSRIs) affect levels of inflammatory markers in patients withMDD, but studies have reported inconsistent findings. This systematic review and meta-analysis aims toinvestigate the effects of SSRIs treatment on peripheral levels of a range of inflammatory markers in MDDpatients. Methods: Systematic literature search (Pubmed, Web of Science, Embase, Cochrane) for trialspublished before November 2016 were conducted. Studies were included if they used SSRI monotherapyand peripheral levels of interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-α, andinterferon (IFN)-γ were measured before and after treatment in patients with MDD. Meta-analysis wasconducted using Comprehensive Meta-analysis (version 2). Effect sizes were calculated using biascorrected standardized mean difference (Hedges’ g) between pre- and post-treatment. Sub-group analysesand publication bias estimates were undertaken; sensitivity analyses were performed using differentestimated pre- and post-treatment correlations and after removing poor quality studies. Results: Sixteeneligible studies including 570 MDD patients were included in the meta-analysis: 10 studies for IL-6; 7 forTNF-α; 5 for IL-1β, IL-4 and IL-10; 4 for IL-2; and 3 for IFN-γ. The pooled effect estimate indicates SSRI treatment decreased levels of pro-inflammatory markers IL-6 (Hedges’ g, -0.428; 95%CI, -0.699 to -0.158;I2=84.867) and IL-1β (Hedges’ g=-0.873; 95%CI, -1.702 to -0.043; I2=94.237), and anti-inflammatory markerIL-10 (Hedges’ g=-0.535; 95%CI, -0.987 to -0.084; I2=84.369). There were no significant treatment effects onlevels of IL-2, IL-4, TNF-α, or IFN-γ. There was a high level of heterogeneity between studies. Sub-group analyses on studies involving IL-6 indicated the high heterogeneity was not explained by age, gender, sample size, drug dosage, study duration or study design. No evidence of publication bias was found. Sensitivity analyses indicated the robustness of the primary analyses. Conclusions: High heterogeneity between studies limits interpretation, but meta-analysis indicates moderate immunoregulatory effects of SSRIs treatment for MDD, which suggests SSRIs may owe some of their therapeutic effect to their anti-inflammatory propertie
Flexible Sn0₂/n-doped carbon nanofiber films as integrated electrodes for lithium-ion batteries with superior rate capacity and long cycle life
No full textA freestanding SnO₂ @N-CNF film prepared by electrospinning exhibits excellent flexibility and a high surface area of 506 m²g⁻¹ . When used as an anode for lithium-ion batteries, a high reversible capacity of 754 mAh g⁻¹ is maintained after the 300(th) cycle at 1 A g⁻¹ . Even when the current density increases to 5 A g⁻¹ , the SnO2 @N-CNF still delivers 245.9 mAh g⁻¹ .Lu Xia, Suqing Wang, Guoxue Liu, Liangxing Ding, Dongdong Li, Haihui Wang, and Shizhang Qia
Interconnected α-Fe₂O₃ nanosheet arrays as high-performance anode materials for lithium-ion batteries
No full textAbstract not availableDandan Cai, Dongdong Li, Liang-Xin Ding, Suqing Wang, Haihui Wan
sj-pdf-1-pid-10.1177_09544070231205063 – Supplemental material for Study on dynamic prediction method for degradation state of electric drive system based on deep learning and uncertainty quantification
No full textSupplemental material, sj-pdf-1-pid-10.1177_09544070231205063 for Study on dynamic prediction method for degradation state of electric drive system based on deep learning and uncertainty quantification by Zhen Wang, Lihui Zhao, Dongdong Zhang and Chuliang Yan in Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering</p
Fig. 1 in Four undescribed sulfur-containing indole alkaloids with nitric oxide inhibitory activities from Isatis tinctoria L. roots
No full textFig. 1. Structures of compounds 1−7.Published as part of Zhang, Dongdong, Ruan, Deqing, Li, Jingyi, Chen, Zhaoqiang, Zhu, Weiliang, Guo, Fujiang, Chen, Kaixian, Li, Yiming & Wang, Rui, 2020, Four undescribed sulfur-containing indole alkaloids with nitric oxide inhibitory activities from Isatis tinctoria L. roots, pp. 1-6 in Phytochemistry (112337) 174 on page 2, DOI: 10.1016/j.phytochem.2020.112337, http://zenodo.org/record/829478
sj-pdf-2-ccx-10.1177_10732748211066309 – Supplemental Material for Effect of Marital Status on the Survival of Patients With Adenocarcinoma of the Esophagogastric Junction: A Population-Based, Propensity-Matched Study
No full textSupplemental Material, sj-pdf-2-ccx-10.1177_10732748211066309 for Effect of Marital Status on the Survival of Patients With Adenocarcinoma of the Esophagogastric Junction: A Population-Based, Propensity-Matched Study by Sihan Wang, Liubo Chen, Dongdong Chen, Jian Chao, Yangliu Shao, Kejun Tang and Wenteng Chen in Cancer Control</p
sj-docx-1-crx-10.1177_00936502231154146 – Supplemental material for When the Personal Becomes Political: Unpacking the Dynamics of Sexual Violence and Gender Justice Discourses Across Four Social Media Platforms
No full textSupplemental material, sj-docx-1-crx-10.1177_00936502231154146 for When the Personal Becomes Political: Unpacking the Dynamics of Sexual Violence and Gender Justice Discourses Across Four Social Media Platforms by Jiyoun Suk, Yini Zhang, Zhiying Yue, Rui Wang, Xinxia Dong, Dongdong Yang and Ruixue Lian in Communication Research</p
Fig. 4 in Four undescribed sulfur-containing indole alkaloids with nitric oxide inhibitory activities from Isatis tinctoria L. roots
No full textFig. 4. Experimental and calculated ECD spectra of isatisindigoticanine I (2).Published as part of Zhang, Dongdong, Ruan, Deqing, Li, Jingyi, Chen, Zhaoqiang, Zhu, Weiliang, Guo, Fujiang, Chen, Kaixian, Li, Yiming & Wang, Rui, 2020, Four undescribed sulfur-containing indole alkaloids with nitric oxide inhibitory activities from Isatis tinctoria L. roots, pp. 1-6 in Phytochemistry (112337) 174 on page 3, DOI: 10.1016/j.phytochem.2020.112337, http://zenodo.org/record/829478
Effects of SSRIs on peripheral inflammatory markers in patients with major depressive disorder: a systematic review and meta-analysis
No full textIntroduction: Peripheral levels of inflammatory markers are elevated in major depressive disorder (MDD). Selective serotonin reuptake inhibitors (SSRIs) affect levels of inflammatory markers in patients with MDD, but studies have reported inconsistent findings. This systematic review and meta-analysis aims to investigate the effects of SSRI treatment on peripheral levels of a range of inflammatory markers in MDD patients. Methods: Systematic literature search (Pubmed, Web of Science, Embase, Cochrane) for studies published beforeNovember 2018. Studies were included if they used SSRI monotherapy and peripheral levels of interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ were measured before and after treatment in patients with MDD. Meta-analysis was conducted using Comprehensive Meta-analysis (version 2). Effect sizes were calculated using bias-corrected standardized mean difference (Hedges’ g) between pre- and post-treatment. Sub-group analyses, meta-regression and publication bias estimates were undertaken; sensitivity analyses were performed using different estimated pre- and post-treatment correlations and after removing poor quality studies.Results: Twenty two eligible studies including 827 MDD patients were included in the meta-analysis: fifteen studies for IL-6; eleven for TNF-α; eight for IL-10; seven for IL-1β; six for IL-4; five for IL-2; and four for IFN-γ. The pooled effect estimate indicates SSRI treatment decreased levels of pro-inflammatory markers IL-6 (Hedges’ g, -0.418; 95%CI, −0.663 to −0.174; I2=89.412), TNF-α (Hedges’ g, −0.554; 95%CI, −0.990 to −0.118; I2=95.438) and IL-1β (Hedges’ g=−0.574; 95%CI, −1.014 to −0.135; I2=91.622), and anti-inflammatory marker IL-10 (Hedges’ g=−0.615; 95%CI, −0.989 to −0.242; I2=90.406). There were no significant treatment effects on levels of IL-2, IL-4, or IFN-γ. There was a high level of heterogeneity between studies. Sensitivity analyses indicated the robustness of the primary analyses. Conclusions: The current review and meta-analysis indicates moderate immunomodulating effects of SSRI treatmentfor MDD, which suggests SSRIs may owe some of their therapeutic effect to their anti-inflammatory properties. High heterogeneity across studies may limit interpretation of the findings and larger randomized clinical trials are warranted
Natural products in diabetes research: quantitative literature analysis
Get PDFThe current study aimed to identify which natural products and which research directions are related to the major contributors to academic journals for diabetes therapy. Bibliometric data were extracted from the Web of Science online database using the search string TOPIC=(natural product* OR natural compound* OR natural molecule* OR phytochemical* OR secondary metabolite*) AND TS=(diabet*) and analysed by a bibliometric software, VOSviewer. The search yielded 3694 publications, which were collectively cited 80,791 times, with an H-index of 117 and 21.9 citations per publication on average. The top-contributing countries were India, the USA, China, South Korea and Brazil. Curcumin, flavanone, resveratrol, carotenoid, polyphenols, flavonol, flavone and berberine were the most frequently cited natural products or compound classes. Our results provide a brief overview of the major directions of natural product research in diabetes up to now and hint on promising avenues for future research.Atanas G. Atanasov acknowledges the support of the Polish KNOW (Leading National Research
Centre) Scientific Consortium ‘Healthy Animal – Safe Food’, decision of the Ministry of Science
and Higher Education No. 05-1/KNOW2/2015. Dongdong Wang acknowledges the Cultivation
project for clinical medicine of the integrated traditional Chinese and western medicine and
Cultivation project for education team of internal medicine of the integrated traditional Chinese
and western medicine in the first-term subjects with special support in the first-class universities
in Guizhou province (Qin Jiao Gao Fa No. 2017-158). Javier Echeverría gratefully acknowledges
funding from CONICYT (PAI/ACADEMIA No. 79160109).info:eu-repo/semantics/publishedVersio
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