2,313 research outputs found
A thermomechanical approach for micromechanical continuum models of granular media
No full text© 2005 Dr. Stuart D. C. WalshThe term “granular material” describes any assembly of macroscopic particles. This broad definition encompasses a wide variety of everyday materials, for example sand, cereals, gravel and powders. However, despite their commonplace nature, to date no universally accepted set of constitutive equations exists to describe the behaviour of these materials. Thermomechanics and micromechanics are two modelling methodologies previously employed in separate efforts to represent granular behaviour. In this thesis, the two theories are integrated to develop new models of idealised granular materials. (For complete abstract open document
Corrigendum: Pneumococcal vaccine impacts on the population genomics of non-typeable haemophilus influenzae: (Microbial Genomics 2021; 9, 10.1099/mgen.0.000209)
No full textThere was a change in the author names in the published article. The new list should read: David W. Cleary1,2, Vanessa T. Devine3, Denise E. Morris1, Karen L. Osman1, Rebecca A. Gladstone4, Stephen D. Bentley4, Saul N. Faust1,5, Stuart C. Clarke1,2,6 1Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK. 2NIHR Southampton Biomedical Research Centre, University Hospital Southampton Foundation NHS Trust, Southampton, UK. 3Northern Ireland Centre for Stratified Medicine and Clinical Translational Research Innovation Centre, Londonderry, UK. 4Pathogen Genomics, Wellcome Trust Sanger Institute, UK. 5NIHR Southampton Clinical Research Facility, University Hospital Southampton Foundation NHS Trust, Southampton, UK. 6Global Health Research Institute, University of Southampton, Southampton, UK.</p
Advance Australia fair [music] /
No full textNew ed. For chorus (SATB); Issued as a postcard.; "Commonwealth anthem and patriotic song".; "Performed by the massed bands at the Naming of the Federal Capital Celebrations, Canberra".; "The author of this song ... is indebted to the late Professor Stuart Blackie, of Edinburgh for improvement in last verse".; 3rd verse begins: 'Beneath our radiant Southern Cross ...'; Also available online http://nla.gov.au/nla.mus-an6397900; MUS: N, A, N/A, B, C, JAF.Advance Australia fair. Chorus scor
Redemption in the work of Francis Stuart
No full textThe idea of redemption is central to an understanding of the work
of Francis Stuart. Through an examination of its development and
expression, it is possible to demonstrate the integrity of his work and
its distinctive qualities. Such a demonstration is necessary because
Stuart's writing has been subjected to comparatively little scholarly
inquiry, although reviews of his work, especially that produced since
1949, suggest that it is impressive and important.
First, a general background to Stuart's work, a discussion of the
special problems associated with reading it, and a summary of his corpus
is provided. This indicates that the idea of redemption is important to
his earliest writing. The state of redemption is shown to be a
necessary apotheosis for Stuart's outcast heroes; it involves spiritual
suffering through which may be found a sense of reintegration and a
higher reality. This is expressed through interrelated themes such as
those of gambler, artist and ordinary man; mystic and criminal; sacred
and profane love; and spirituality and the mundane. The nature of the
redemptive experience is further elaborated by distinctive, complex
motifs, especially the hare, the ark and the woman-Christ. Their
recurrence provides an important element in the unity of Stuart's work.
Because Stuart's idea of the outcast raises important biographical
questions, an examination of the relationship between Stuart's life and
his work is made. Finally, the way in which the idea of redemption
exists in the language structures of Stuart's novels is examined, with
especial reference to his most recent work, The High Consistory. The
thesis shows that the development of the these of redemption
demonstrates the integrity of Stuart's work
John Stuart Mill’s projected science of society: 1827-1848
No full textThe purpose of the thesis is to examine John Stuart Mill’s political thought from
about 1827 to 1848 as an exercise in intellectual history. It focuses, first, on Mill’s view,
formulated by the late 1830s, that contemporary society was ‘civilized’, and second, on
his project of a science of society, which he aspired to develop in the late 1830s and
early 1840s.
By the late 1830s, Mill came to the view that his contemporary society was a
‘commercial society or civilization’, dominated by the middle, commercial class. The
first part of my thesis, constituted by Chapters 2-4, discusses the way in which Mill
formed his notion of civilization, and what he meant by the term ‘civilization’. Mill paid
attention to the implications of the rise of the middle class, and regarded such
phenomena of contemporary society as the corruption of the commercial spirit and
excessive social conformity as an inevitable consequence of the rise of the middle class.
The second part of the thesis, constituted by Chapters 5-9, examines Mill’s
projected science of society. In the late 1830s and early 1840s, Mill attempted to
develop a new science of society whose subject-matter was the nature and prospects of
commercial, civilized society. This aspiration culminated in A System of Logic,
published in 1843. In examining Mill’s projected science, I pay particular attention to
the fact that he conceived new sciences of history and of the formation of character,
both of which were indispensable in his project, although he failed to give a complete
account of these sciences. My thesis shows that the implications of his interest both in
history and in the formation of character are more significant than Mill scholars have
assumed
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No full text© 2021, L. Cassidy, D. Hannibal, S. Semple, B. McCowan. This is an author produced version of a paper published in AMERICAN JOURNAL OF PRIMATOLOGY uploaded in accordance with the publisher’s self- archiving policy. The final published version (version of record) is available online at the link. Some minor differences between this version and the final published version may remain. We suggest you refer to the final published version should you wish to cite from it
High pressure phase transformations in polycrystalline yttrium oxide
No full textNumerous studies have been performed on high-pressure/high temperature phase transitions in rare-earth sesquioxides. Most of these studies were performed using diamond-anvil presses, which limits the size of samples that can be processed. Hence, studies of microstructural and properties changes accompanying phase transitions have been largely neglected. The purpose of this study has been to fill this gap, working with polycrystalline cubic-Y2O3 because of its importance in IR window and dome applications. We selected Diamond Materials Inc. as partner in this investigation, since this company has the expertise to make test pieces under well-controlled HPHT-processing conditions, thus ensuring that the results obtained for one batch of samples to the next are reproducible. This turned out to be crucial, since variations in applied pressure (1.0 to 8.0 GPa range), and holding times (seconds to hours), resulted in significant changes in observed micro/nano-structures. The temperature was fixed at 1000°C in order to limit HPHT-processing variables to pressure and holding time. In view of the results reported here, it now seems clear that extending the investigation to higher temperatures and lower pressures would be productive. The principal accomplishments of this research are as follows: (1) optimization of a reversible-phase transformation process to convert polycrystalline cubic-Y2O3 into the nanocrystalline state, involving a forward-phase transformation from cubic-to-monoclinic (c-to-m) Y2O3 at a high pressure (8.0 GPa) followed by a reverse-phase transformation from monoclinic-to-cubic (m-to-c) Y2O3 at a lower pressure (1.0 GPa); (2) discovery of a transformation-induced crystallization process to convert polycrystalline c-Y2O3 into columnar-grained m-Y2O3, and possibly into single-crystal m-Y2O3 - the driving force is attributed to a pressure-induced phase transformation that occurs at the tips of the growing columnar-grains; (3) formation of a mixed-phase (c-Y2O3/m-Y2O3) nanocomposite due to incomplete reverse transformation from m-to-c Y2O3 - a near 50:50 nanocomposite displays the highest hardness; and (4) insight into infiltration of carbon-containing gases (e.g. CO, CO2), formed via reactions between carbon heater and entrapped gases (e.g. O2, H2O) in the pressure cell, into cracked grain boundaries to form carbon particles/films via a vapor-deposition mechanism, and into uncracked grain boundaries to form carbon-rich species via a boundary-diffusion mechanism.Ph. D.Includes bibliographical referencesby Stuart Deutsc
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
Mental health consultation in state government: a program evaluation
No full textThe Clinical Consultant position was established by the New Jersey Division of Child Behavioral Health (DCBHS) to provide clinical guidance to caseworkers from the Division of Youth and Family Services (DYFS) tasked with the job of managing the complex needs of the children and families under their supervision. Due to the urgency of the need for this service the Clinical Consultant position was created and implemented with a loose job definition while an extensive needs assessment and program evaluation was conducted that would form the basis for an informed, comprehensive and detailed training manual. This needs assessment and program evaluation was carried out by the author eighteen months after the position was formally implemented, with the goals of a) identifying the most critical issues that the clinical consultants face, b) clarifying and refining the organizational conceptualization of the position, c) providing a resource for the clinical consultants to assist them in carrying out their duties effectively and efficiently and d) standardizing practice. The methods used in carrying out this program evaluation were modeled on those described by Hepburn, Kaufmann, Perry, Allen, Brennan and Green in Early childhood mental health consultation: An evaluation tool kit, and involved an extensive review of the consultation and organizational diagnosis literature, semi-structured interviews with involved personnel, and observation. A qualitative database was created from the semi-structured interviews identifying important themes and analyzing them within the larger context of the theoretical foundations of mental health consultation. Specific duties and tasks associated with these dimensions were isolated and examined in light of these theoretical foundations and within the framework of practical and logistic considerations. Presentations of findings were made to major stakeholder groups. The significant themes that arose from the evaluation included differing organizational understandings of the Clinical Consultant position, varying conceptions of the important dimensions of the position and associated tasks, and significant inter-system dynamics influencing communication and utilization of the position at large. These are considered with relevant observations from the author’s own experience serving as a consultant to the larger system in which the Clinical Consultants operate.Psy. D.Includes bibliographical referencesby Kathryne Stuart Blauvel
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