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Remembering Kenneth G. Holum
No full textReminiscences by: Gideon Avni, Israel Antiquities Authority and Hebrew University of Jerusalem Elizabeth Conner, University of Maryland Alan Walmsley, Macquarie Universit
Remembering Kenneth G. Holum
No full textReminiscences by: Gideon Avni, Israel Antiquities Authority and Hebrew University of Jerusalem Elizabeth Conner, University of Maryland Alan Walmsley, Macquarie Universit
Anisotropy Effects in Superconductive Tunnelling
No full textTitle: Anisotropy Effects in Superconductive Tunnelling, Author: David G. Walmsley, Location: ThodeThe application of the microscopic theory of superconductivity
to the results of experiments on quantum-mechanical electron tunnelling
between superconductors is discussed. A cryostat and associated electrical
circuitry, constructed for tunnelling experiments, are described.
There is a discussion of sample fabrication techniques which have
received much attention, and have been extended, during the course of
this work. Finally, results obtained on the metals aluminium, indium,
tin, and lead are illustrated, and interpreted with particular emphasis
on superconductor energy gap anisotropy.ThesisDoctor of Philosophy (PhD
Paul, Mark, Barnabas or G. Walmsley Memorial Window
No full textVignette of sailboat and coat of arms Canadian Air Force. Inscriptions: IHS / PAUL / MARK / BARNABAS and IN LOVING MEMORY OF / GEORGE WALMSLEY / 1923 – 1988 / PRESENTED BY HIS WIFE ELANOR / & SONS FRANK, CHRIS & JEFF. Signed: CRW, CHRISTOPHER WALLIS, LONDON ONTARIO 1988. Lead Investigator: C. Cody Barteet ([email protected]). Photograph: Katie Oateshttps://ir.lib.uwo.ca/chriswallis_stainedglass_on_london_stmarks/1067/thumbnail.jp
Heat Integrated Milk Powder Production
No full textDairy processing is critical to New Zealand’s (NZ) economy producing NZ3 million and internal rate of return of 71 %. This tool will empower industry with greater confidence to uptake exhaust heat recovery technology as a vital method for improving the heat integration of MPPs in NZ
Detail, Inscription from Paul, Mark, Barnabas or G. Walmsley Memorial Window
No full textInscriptions: IN LOVING MEMORY OF / GEORGE WALMSLEY / 1923 – 1988 / PRESENTED BY HIS WIFE ELANOR / & SONS FRANK, CHRIS & JEFF. Signed: CRW, CHRISTOPHER WALLIS, LONDON ONTARIO 1988. Lead Investigator: C. Cody Barteet ([email protected]). Photograph: Katie Oateshttps://ir.lib.uwo.ca/chriswallis_stainedglass_on_london_stmarks/1075/thumbnail.jp
«The Virgin Adoring the Christ Child (the Ruskin Madonna)», Andrea del Verrocchio and Domenico Ghirlandaio, National Galleries of Scotland, Edimburgo
No full textDetail, Vignettes, Inscription, and Signature from Paul, Mark, Barnabas or G. Walmsley Memorial Window
No full textVignette of sailboat and coat of arms Canadian Air Force. Inscriptions: IN LOVING MEMORY OF / GEORGE WALMSLEY / 1923 – 1988 / PRESENTED BY HIS WIFE ELANOR / & SONS FRANK, CHRIS & JEFF. Signed: CRW, CHRISTOPHER WALLIS, LONDON ONTARIO 1988. Lead Investigator: C. Cody Barteet ([email protected]). Photograph: Katie Oateshttps://ir.lib.uwo.ca/chriswallis_stainedglass_on_london_stmarks/1070/thumbnail.jp
Economic Analysis of U.S. Immigration Reforms
No full textIn January 2004, President George Bush proposed the creation of a temporary worker program to allow more migrant workers to enter the US legally. This new temporary worker program would be open to undocumented workers in the US, as well as to prospective migrants currently residing abroad. The program would temporarily allow immigrants to fill jobs that, according to employers, would otherwise go unfilled at the current wage. The US Congress vetoed the presidential proposal, however, and requested a stricter enforcement of immigration law and the consequent deportation of undocumented immigrants. This study analyzes the economic effects of these immigration reforms on the US economy using an applied global general equilibrium model of migration. In this paper the global trade and migration model (GMig2) developed by Walmsley, Winters and Ahmed (2007) is modified to include a third labor category – undocumented unskilled – to reflect estimates of undocumented workers residing in the United States. The model is then used to analyze the impacts of two policy scenarios on the US economy: first, the deportation of undocumented workers currently residing in the US; and second, the legalization of undocumented agricultural workers. The first scenario is implemented through a decline in the number of undocumented workers residing in the US to zero, and a corresponding increase in the number of workers in Mexico. The second scenario is achieved by allowing undocumented workers to obtain legal status, thereby increasing their wages and productivity. We find that the deportation of undocumented workers causes a considerable loss to the US economy in terms of real GDP. Legalization of Mexican undocumented immigrants, on the other hand, is found to increase US real GDP. Hence the paper demonstrates there are clear advantages to the US economy of implementing proposals that both allow migrant workers to remain in the United States and increase the workers ability to participate freely in the US labor force as legal residents.US Undocumented Workers, Applied General Equilibrium, Political Economy,
The regulation of the cAMP signalling pathway in the human pathogenic fungus Paracoccidioides brasiliensis
No full textParacoccidioides brasiliensis (Pb) is the causative agent of the disease Paracoccioidomycosis (PCM), which is one of the most prevalent systemic mycoses in Latin Amercia (Borges-Walmsley et al., 2002). P. brasiliensis is a thermally dimorphic fungus which undergoes morphological changes from a mycelial form at 26 C (environment) to a pathogenic yeast form at 37 C (human body) after inhalation of spores/conidia into the lungs of a human host (Nemecek et al., 2006). The cAMP pathway controls this morphological transformation in several fungi (Borges-Walmsley and Walmsley, 2000; Kronstad et al., 1998). G proteins are guanine-nucleotide (GDP or GTP) binding proteins that are generally associated with the cytoplasmic side of the plasma membrane. They receive signals from G protein-coupled receptors (GPCR). Adenylyl cyclase acts downstream of these G proteins. Ga subunits are required to regulate the activity of adenylyl cyclase (AC), which controls the level of cellular cAMP (Ivey and Hoffman, 2005). Protein Kinase A (PKA), which is activated by cAMP, is required for morphogenesis and virulence (Durrenberger et al., 1998; Sonnebom et al., 2000). The cAMP pathway in P. brasiliensis is poorly understood. However, recently the genes encoding a number of the components of the cAMP pathway have been cloned in our lab: these include the genes encoding three Ga proteins, Gpal-3, a Go protein, Gpb1; a Gy protein, Gpg1; Ras; adenylyl cyclase, Cyr1; and the catalytic subunit of PKA, Tpk2. Two-hybrid analyses confirmed that Gpa1 and Gpg1 interact with Gpb1. These data indicate the formation of a Gaβy trimer complex. A GST pull-down assay confirmed that Gpa1 and Gpb1 interacted with the N-teminus of adenylyl cyclase. Our hypothesis is that Gpa1 and Gpb1 modulate the activity of the AC/Tpk2 signalling pathway. Consistent with this hypothesis, we found changes in intracellular cAMP levels during the mycelium to yeast transformation that correlated with changing transcript levels of the signalling genes (Chen et al., 2007). We have established that Tpk2 interacts with the N-terminus of adenylyl cyclase, the G protein β subunit Gpb1 and with the co-repressor Tup1 by both two-hybrid and GST pull down analyses. This suggests that Tpk2 activity is required for feedback regulation of adenylyl cyclase to reduce cAMP levels. P. brasiliensis Tpk2-C-terminal 226-583-GFP and Tpk2 full length (FL) complemented the growth defect of a S. cerevisiae tpk2 temperature sensitive mutant strain SGY446 and induced the formation of pseudohyphue in the S. cerevisiae tpk2 mutant diploid strain XPY5a/a. Tpk2 C-tenninus has been over expressed in E. coli and in vitro PKA activity was measured. On the other hand we have also analysed the second catalytic subunit Tpk1, which failed to induce pseudohyphae in S. cerevisiae tpk1 inutant strain and is localised to the cytoplasm. Interestingly, the Pb Gβ subunit Gpb1 inhibited the development of pseudohyphae in TPK2 FL transformed yeast cells. Tpk2 C-terminus and Tpk2 FL co-transformed with Gpb-GFP were localized in the nucleus. Our hypothesis is that Gpb1 down regulates the activity of Tpk2, because Gpb1 binds to the catalytic C-terminal domain of Tpk2
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