145 research outputs found
Total intravenous anaesthesia using propofol and sufentanil allows controlled long-term ventilation in rabbits without neuromuscular blocking agents.
No full textThe aim of this study was to evaluate a total intravenous anaesthesia (TIVA) protocol using propofol and sufentanil without neuromuscular blocking agents (NBAs) for a non-recovery lung pathology study in rabbits including 10 h of pressure-controlled ventilation. TIVA was started with 20 mg/kg/h propofol and 0.5 mg/kg/h sufentanil. The depth of anaesthesia was assessed by reflex testing and monitoring of spontaneous movements or respiratory efforts. Vital parameters were monitored to assess the effects of the TIVA protocol. The infusion rates were increased whenever reflex testing indicated inadequate depth of anaesthesia, and were reduced when vital parameters indicated unnecessarily deep levels. Median infusion rates of 35 mg/kg/h propofol and 2.0 mg/kg/h sufentanil were needed to ensure an adequate depth of anaesthesia. This protocol suppressed spontaneous movements, breathing and palpebral reflexes, but was unable to suppress corneal and pedal withdrawal reflexes. Since significant drops in arterial blood pressure (ABP) were observed and the animals were not exposed to painful procedures, positive corneal and pedal withdrawal reflexes were tolerated. In conclusion, propofol and sufentanil is a suitable combination for long-term anaesthesia in non-recovery lung pathology models in rabbits without painful procedures. ABP must be monitored carefully because of the circulatory side-effects, but it is an inappropriate surrogate marker for depth of anaesthesia. Due to the lack of neuromuscular blockade this TIVA protocol allows the adjustment of infusion rates based on reflex testing. The resulting decreased risk of unnoticed awareness is a decisive refinement in anaesthesia for similar studies including long-term mechanical ventilation in rabbits
Jean-Etienne Liotard und Karoline Luise von Baden: Eine Geschichte der Pastelle
No full textDas Rijksmuseum in Amsterdam beherbergt nach dem Musée d’Art et d’Histoire in Genf die zweitgrößte Sammlung von Pastellgemälden von Jean-Etienne Liotard (1702-1789). Im Hinblick auf die Wiedereröffnung des Museums 2013 wurde im Jahr 2007 ein großes Restaurierungs- und Forschungsprojekt zu den Pastellen initiiert. Die 23 Werke Liotards wurden aus dem Rahmen genommen und dokumentiert; 13 von ihnen wurden restauriert. Um die von Liotard verwendeten Techniken zu rekonstruieren, wurden sowohl Materialproben als auch schriftliche Quellen herangezogen. Neben seinem Traité des principes et règles de la peinture (1781) bilden die erhaltenen Unterlagen seiner einzigen Schülerin in der Pastellmalerei, Karoline Luise von Baden (1723-1783), einen einmaligen und unmittelbaren Beleg für Liotards Praxis. Die Untersuchung der Beziehung zwischen dem Schweizer Künstler und seiner Schülerin führte zur Wiederentdeckung einer Pastellkreidenprobe des Herstellers Bernard-Augustin Stoupan (1701-1775) Zusammenhang mit den technischen Beobachtungen stehen, die an Liotards Pastellen gemacht wurden. Eine eingehende Untersuchung von Liotards Pastelltechniken im Allgemeinen wurde bereits im Jahr 2014 veröffentlicht.Aerospace Structures and MaterialsAerospace Engineerin
Literatur und Emanzipation von Frauen in der Frühromantik : Bettine von Arnim und Karoline von Günderrode
No full textEarly German Romanticism is a period associated in literary analysis with the emancipation of women. Two women writers of the time. Bettine von Arnim and Karoline von Günderrode take up the Romantic view of literature as an emancipating medium. The thesis refers to Romanticism to define the concepts of feminity, literature and emancipation within their historical context. Romanticism attempts a dialogue between the self and its other, and ultimately re-defines woman as the other of the author male. Friedrich Schlegel's novel Lucinde is analysed as a paradigmatic example of the identification of the self through the medium of literature. The writings of Bettine and Karoline have been analysed as early examples of a feminist literary tradition from the standpoint of feminist theory located in the context of modern women's movements. By way of contrast to Romantic literary theory, this feminist literary theory is expressed as a perceived continuity of women's experience. The concept of self-realisation of women authors through literature is examined from the standpoint of understanding literary texts as objectification of self. French feminist criticism is employed to analyse the relation of feminity to systems of representations from the perspective of modern textual practice. It is argued that Bettine's novel is structured around the literary correspondence between herself and Karoline in which they were able to create a "free-space" (Freiraum) in order to discuss their alienation from society. In realising Romanticism's concept of a dialogue. Bettine achieves a new concept of authorship which allows a representation of female desire, as defined by French theory, through a reflection in Karoline as her other. While both women enjoy the advantage of education. Bettine rejects this as an example of male norms. Karoline imitates these norms to emancipate herself. Karoline identifies with the dominant aesthetic norms in her poetry in an attempt at identification. Her letters, on the other hand, reflect a modern experience of discontinuity of self, which she explains as a result of the absence of social practice in the society of her time and the limitations imposed on her as a woman. In the thesis, it is concluded that Karoline's production is difficult to reconcile with either of the above literary theories. Neither Karoline's nor Bettine's literature can be seen as representative of a unified female subject. The medium of literature enables the development of an aesthetic subjectivity, which, it is argued, can be applied to women-specific" (frauenspezifisch) criticism
Constructional change in North American Danish transitional verbs: The case of var født/konfirmeret/gift
No full textThis paper focuses on structural changes in Danish as an immigrant minority language in North America, i.e., language change under the conditions of language contact. Two corpora, the Corpus of North American Danish and the LANCHART corpus (both University of Copenhagen), provide data for a contrastive analysis of auxiliary choice in three verb phrases with transitional biographical verbs (født 'born', konfirmeret 'confirmed' and gift 'married') in North American Danish and modern spoken Danish. Taking a Construction Grammar approach, the author argues that the changes in auxiliary choice, namely the use of var 'was' instead of blev 'became', are the result of cross-linguistic analogy building by the bilingual speakers of North American Danish. The analogical leveling of North American Danish with English leads to constructional change in form and function as well as in frequency and prototype
The pre-hospital administration of tranexamic acid to patients with multiple injuries and its effects on rotational thrombelastometry: a prospective observational study in pre-hospital emergency medicine
No full textBackground: Hyperfibrinolysis (HF) is a major contributor to coagulopathy and mortality in trauma patients. This study investigated (i) the rate of HF during the pre-hospital management of patients with multiple injuries and (ii) the effects of pre-hospital tranexamic acid (TxA) administration on the coagulation system. Methods: From 27 trauma patients with pre-hospital an estimated injury severity score (ISS) >= 16 points blood was obtained at the scene and on admission to the emergency department (ED). All patients received 1 g of TxA after the first blood sample was taken. Rotational thrombelastometry (ROTEM) was performed for both blood samples, and the results were compared. HF was defined as a maximum lysis (ML) >15 % in EXTEM. Results: The median (min-max) ISS was 17 points (4-50 points). Four patients (15 %) had HF diagnosed via ROTEM at the scene, and 2 patients (7.5 %) had HF diagnosed via ROTEM on admission to the ED. The median ML before TxA administration was 11 % (3-99 %) vs. 10 % after TxA administration (4-18 %; p > 0.05). TxA was administered 37 min (10-85 min) before ED arrival. The ROTEM results before and after TxA administration did not significantly differ. No adverse drug reactions were observed after TxA administration. Discussion: HF can be present in severely injured patients during pre-hospital care. Antifibrinolytic therapy administered at the scene is a significant time saver. Even in milder trauma fibrinogen can be decreased to critically low levels. Early administration of TxA cannot reverse or entirely stop this decrease. Conclusions: The pre-hospital use of TxA should be considered for severely injured patients to prevent the worsening of trauma-induced coagulopathy and unnecessarily high fibrinogen consumption
Erratum: The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition (Proceedings of the National Academy of Sciences of the United States of America (2020) 117 (4180-4187) DOI: 10.1073/pnas.1913481117)
No full textCorrection for “The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition,” by Simone F. Glaser, Andreas W. Heumüller, Lukas Tombor, Patrick Hofmann, Marion Muhly-Reinholz, Ariane Fischer, Stefan Günther, Karoline E. Kokot, David Hassel, Sandeep Kumar, Hanjoong Jo, Reinier A. Boon, Wesley Abplanalp, David John, Jes-Niels Boeckel, and Stefanie Dimmeler, which was first published February 7, 2020; 10.1073/pnas.1913481117 (Proc. Natl. Acad. Sci. U.S.A. 117, 4180-4187). The authors note that Hitoshi Okada should be added to the author list between Karoline E. Kokot and David Hassel. Hitoshi Okada should be credited with providing mice. The corrected author line, affiliation line, and author contributions appear below. The online version has been corrected
Privat eller offentlig? : En studie av kändisbloggens innehåll och läsarnas kommentarer
No full textAbstractTitle: Private or public? A study of the content in the celebrity blog and the readers'comments. (Privat eller offentlig? En studie av kändisbloggens innehåll och läsarnaskommentarer)Number of pages: 36 (37 including enclosure)Author: Karoline FrankTutor: Else NygrenCourse: Media and Communication studies CPeriod: Fall semester 2009University: Uppsala UniversityAim: The aim of this study is to examine the boundary between the private and the public asit is expressed in a number of blogs written by Swedish celebrities.Material/Method: Qualitative textual analysis of four blogs written by Swedishcelebrities.The total amount of analyzed blog posts were 120, since 30 posts from each of theblogs were selected. Also the comments on the blog posts, given by the blog readers wereexamined.Main results: The examined blogs written by celebrities contain both issues that can beconsidered as private and public. The celebrities write about their families, especially theirchildren but, also about their partners as well as they write about things such as movies orrestaurants that they recommend. They also express their emotions relatively often. Only twoof the celebrities wrote something that can be considered to associate with their professionbut, only in one blog post each. Also, two of the celebrities made a treatment against media.Keywords: celebrities, blogs, private, public, Thompson, Giddens, qualitative analysis,comment
HistoryMA_danish_childhood_1999_2011
No full text<p>README</p><p>This is an archive containing items that hold significance for the Danish authors' childhood in the period late 1990's to early 2010's. The authors of the archive are Emma Falbe-Hansen, Andreas Emil Mikkelsen, Asta Bøtkjær Naamansen and Karoline Støjberg Sejersen. The filetypes of the archive are TIFF for pictures and MP3 for sound clips. </p><p>This Zenodo folder contains a media file with the items and a dataset which also includes metadata descriptions and author information. The media file is 164 MB and the dataset is 16.7 KB.</p>
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