2,261 research outputs found
Natural Variation of the Circadian Clock in Neurospora
No full textMost living organisms on earth experience daily and expected changes from the rotation of the earth. For an organism, the ability to predict and prepare for incoming stresses or resources is a very important skill for survival. This cellular process of measuring daily time of the day is collectively called the circadian clock. Because of its fundamental role in survival in nature, there is a great interest in studying the natural variation of the circadian clock. However, characterizing the genetic and molecular mechanisms underlying natural variation of circadian clocks remains a challenging task. In this chapter, we will summarize the progress in studying natural variation of the circadian clock in the successful eukaryotic model Neurospora, which led to discovering many design principles of the molecular mechanisms of the eukaryotic circadian clock. Despite the success of the system in revealing the molecular mechanisms of the circadian clock, Neurospora has not been utilized to extensively study natural variation. We will review the challenges that hindered the natural variation studies in Neurospora, and how they were overcome. We will also review the advantages of Neurospora for natural variation studies. Since Neurospora is the model fungal species for circadian study, it represents over 5 million species of fungi on earth. These fungi play important roles in ecosystems on earth, and as such Neurospora could serve as an important model for understanding the ecological role of natural variation in fungal circadian clocks.Advances in Genetics, Vol. 99
Corrigendum to “A generic multi-level framework for microscopic traffic simulation with automated vehicles in mixed traffic” [Transport. Res. Part C: Emerg. Technol. 110 (2020) 291–311] (Transportation Research Part C (2020) 110 (291–311), (S0968090X19304322), (10.1016/j.trc.2019.11.019))
No full textThe authors regret that a contributing author was missing from the list of authors. The complete list of authors should be: “S.C. Calvert, B. van Arem, & J. W. C. van Lint”. All are with Delft University of Technology, Department of Transport & Planning, The Netherlands updated as above. The authors would like to apologise for any inconvenience caused.Transport and Plannin
Towards the Holy Grail: combining system dynamics and discrete-event simulation in healthcare
No full textThe idea of combining discrete-event simulation and system dynamics has been a topic of debate in theoperations research community for over a decade. Many authors have considered the potential benefits ofsuch an approach from a methodological or practical standpoint. However, despite numerous examples ofmodels with both discrete and continuous parameters in the computer science and engineering literature,nobody in the OR field has yet succeeded in developing a genuinely hybrid approach which truly integratesthe philosophical approach and technical merits of both DES and SD in a single model. In this paperwe consider some of the reasons for this and describe two practical healthcare examples of combinedDES/SD models, which nevertheless fall short of the “holy grail” which has been so widely discussed inthe literature over the past decade
Combining forecasts : forty years later
No full textThis article is dedicated to the memory of Clive Granger, a founding editor of this journal. Its title echoes the title of his invited review article in a special issue of the Journal of Forecasting in 1989. That issue marked the twentieth anniversary of the publication of his article with John Bates, which is widely regarded as the seminal article in the field of forecast combination. This article returns to two of the topics in ‘Combining forecasts – twenty years later’ that are of much current interest, namely the impact of forecasters’ different information sets on the original point forecast combination result, and properties of different methods of combining density forecasts. A parallel result to his inefficiency-of-mean-forecasts result for point forecasts is seen to apply to density forecasts, where logarithmic combination is shown to have some advantage over linear combination
Hybrid simulation for health and social care: the way forward, or more trouble than it’s worth?
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Waste and innovation. How waste companies and government can interact to stimulate innovation in the Dutch waste industry
No full textThis thesis answers the question how government and Dutch waste companies can interact in such a way that innovation is stimulated. The author has developed a method to determine the potential for self-regulation and self-control of a company or an industry. This method is based upon the measurement of degree to which the company has assured legal compliance within the own organisation. Furthermore an approach is given to create innovation-friendly regulation using innovation theoretical principles.Industrial Design Engineerin
Tractatus Duo. Prior, de cycloide et corporibus inde genitis. Posterior, epistolaris in qua agitur de cissopide et corporibus inde genitis et de curvarum ...
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