1,721,135 research outputs found
A striking new treehopper genus Mutilifolia (Hemiptera: Membracidae: Smiliinae: Telamonini), from Costa Rica
No full textWallace, Matthew S. (2015): A striking new treehopper genus Mutilifolia (Hemiptera: Membracidae: Smiliinae: Telamonini), from Costa Rica. Zootaxa 3914 (1): 83-88, DOI: 10.11646/zootaxa.3914.1.
Taxonomic changes in the treehopper genera Helonica Ball, Te la mo na Fitch, and Palonica Ball (Hemiptera: Membracidae: Smiliinae: Telamonini)
No full textWallace, Matthew S. (2015): Taxonomic changes in the treehopper genera Helonica Ball, Te la mo na Fitch, and Palonica Ball (Hemiptera: Membracidae: Smiliinae: Telamonini). Zootaxa 4007 (2): 251-258, DOI: 10.11646/zootaxa.4007.2.
The host plants of the Telamonini treehoppers (Hemiptera: Membracidae: Smiliinae) and the first diagnoses of nymphs for 14 species
No full textWallace, Matthew S. (2014): The host plants of the Telamonini treehoppers (Hemiptera: Membracidae: Smiliinae) and the first diagnoses of nymphs for 14 species. Zootaxa 3878 (2): 146-166, DOI: http://dx.doi.org/10.11646/zootaxa.3878.2.
FIGURE 2 in The host plants of the Telamonini treehoppers (Hemiptera: Membracidae: Smiliinae) and the first diagnoses of nymphs for 14 species
No full textFIGURE 2. Fifth instar nymphal exuviae in lateral aspect. A, Telamona compacta. B, T. decorata. C, T. extrema. D, T. maculata. E, T. tiliae. F, T. tristis. G, T. woodruffi.Published as part of Wallace, Matthew S., 2014, The host plants of the Telamonini treehoppers (Hemiptera: Membracidae: Smiliinae) and the first diagnoses of nymphs for 14 species, pp. 146-166 in Zootaxa 3878 (2) on page 161, DOI: 10.11646/zootaxa.3878.2.2, http://zenodo.org/record/494853
FIGURE 1 in Morphology-based phylogenetic analysis of the treehopper tribe Smiliini (Hemiptera: Membracidae: Smiliinae), with reinstatement of the tribe Telamonini
No full textFIGURE 1. Phylogenetic relationships generated from cladistic analysis of the entire dataset, illustrating the new proposed reclassification of the Smiliini s.l. Analysis in PAUP* resulted in a single most parsimonious tree with 311 steps. Bremer support and synapomorphies for nodes are listed in Table 6.Published as part of Wallace, Matthew S., 2011, Morphology-based phylogenetic analysis of the treehopper tribe Smiliini (Hemiptera: Membracidae: Smiliinae), with reinstatement of the tribe Telamonini, pp. 1-42 in Zootaxa 3047 on page 10, DOI: 10.5281/zenodo.20522
Telamona Fitch 1851
No full textGenus Telamona Fitch 1851 (Figs. 1 A–F) Synonymy. Telamona Fitch 1851: 50. Type species: T. fasciata Fitch 1851 by subsequent designation, junior synonym of T. unicolor Fitch. Helonica Ball 1931: 15. Type species: Thelia excelsa Fairmaire 1846 by original designation; new synonymy. Notes. See notes on Telamona excelsa, below.Published as part of Wallace, Matthew S., 2015, Taxonomic changes in the treehopper genera Helonica Ball, Te la mo na Fitch, and Palonica Ball (Hemiptera: Membracidae: Smiliinae: Telamonini), pp. 251-258 in Zootaxa 4007 (2) on page 252, DOI: 10.11646/zootaxa.4007.2.7, http://zenodo.org/record/24259
FIGURE 1 in Richness of the Nearctic Treehopper Fauna (Hemiptera: Aetalionidae and Membracidae)
No full textFIGURE 1. Map of Nearctic region (center, colored) indicating component subregions (not to scale) with species richness (see legend) for states and provinces. Species reported as questionable are excluded from these counts.Published as part of Deitz, Lewis L. & Wallace, Matthew S., 2012, Richness of the Nearctic Treehopper Fauna (Hemiptera: Aetalionidae and Membracidae), pp. 1-26 in Zootaxa 3423 (1) on page 18, DOI: 10.11646/zootaxa.3423.1.1, http://zenodo.org/record/525447
FIGURE 2 in A striking new treehopper genus Mutilifolia (Hemiptera: Membracidae: Smiliinae: Telamonini), from Costa Rica
No full textFIGURE 2. Female (A) and male (B–E) genitalia, and metathoracic leg (F, G). A, Mutilifolia nishidai, n. sp., paratype: second valvulae, lateral view. B, M. nishidai, holotype: left lateral plate, lateral view. C, M. nishidai, holotype: subgenital plate and left and right style clasp, ventral view. D, M. nishidai, holotype: aedeagus, lateral view. E, Archasia belfragei (Wallace research, #09-160c): left style, ventrolateral view. F, M. nishidai, holotype: left metathoracic tibia and tarsus, ventral view. G, M. nishidai, paratype, left metathoracic femur, lateral view.Published as part of Wallace, Matthew S., 2015, A striking new treehopper genus Mutilifolia (Hemiptera: Membracidae: Smiliinae: Telamonini), from Costa Rica, pp. 83-88 in Zootaxa 3914 (1) on page 87, DOI: 10.11646/zootaxa.3914.1.7, http://zenodo.org/record/28774
Supporting Information: On-Cell Saturation Transfer Difference NMR Spectroscopy on Ion Channels: Characterizing Negative Allosteric Modulator Binding Interactions of P2X7
No full textDouble difference STD NMR spectra for AZ10606120 and JNJ-47965567 with WT hP2X7 (Figures S1 and S2); comparison of AZ10606120 and JNJ-47965567 positions in the binding pocket from XRD of pdP2X7 (Figure S3); comparison of docking poses for AZ10606120 and JNJ-47965567 docked to WT or NAM-site mutant hP2X7 (Figures S4 and S5)P2X7 receptors are important drug targets involved in pathologies ranging from psychiatric disorders to cancer. Being membrane embedded receptors, they are more challenging for structural characterization, and at present, we only have a small number of X-ray and cryo-EM structures for P2X7 bound to antagonists. We demonstrate that saturation transfer difference (STD) NMR on live mammalian cells (on-cell STD NMR) overexpressing P2X7 receptors allows further structural insight on the complexes of P2X7 with two potent negative allosteric modulators, namely, AZ10606120 and JNJ-47965567, via the determination of the binding epitope mapping of the interactions, e.g., the main region of contact between the ligand and the binding pocket. This approach, reported for the first time on membrane-embedded ion channels, in combination with molecular docking, allows us to propose the first NMR-validated ligand binding models for two antagonists as bound to human P2X7 receptors and to correlate the structural knowledge acquired with the pharmacology data. We highlight the transformative potential of this application to aid drug design efforts in a less resource-demanding fashion than X-ray crystallography and cryo-EM, and we envisage on-cell STD NMR to fast become an asset for structure–activity relationship studies helping knowledge-based development of efficient drugs targeting P2X7 and other ion channels/membrane-embedded proteinsPeer reviewe
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