6,548 research outputs found
Anxiogenic effects of CGRP within the BNST may be mediated by CRF acting at BNST CRFR1 receptors
No full textCalcitonin gene-related peptide (CGRP) acting within the bed nucleus of the stria terminalis (BNST) increases anxiety as well as neural activation in anxiety-related structures, and mediates behavioral stress responses. Similar effects have been described following intra-ventricular as well as intra-BNST infusions of the stress-responsive neuropeptide, corticotropin releasing factor (CRF). Interestingly, CGRP-positive terminals within the lateral division of the BNST form perisomatic baskets around neurons that express CRF, suggesting that BNST CGRP could exert its anxiogenic effects by increasing release of CRF from these neurons. With this in mind, the present set of experiments was designed to examine the role of CRFR1 signaling in the anxiogenic effects of CGRP within the BNST and to determine whether CRF from BNST neurons contributes to these effects. Consistent with previous studies, we found that 400 ng CGRP infused bilaterally into the BNST increased the acoustic startle response and induced anxiety-like behavior in the elevated plus maze compared to vehicle. Both of these effects were attenuated by 10 mg/kg PO of the CRFR1 antagonist, GSK876008. GSK876008 alone did not affect startle. An intra-BNST infusion of the CRFR1 antagonist CP376395 (2 mu g) also blocked increases in acoustic startle induced by intra-BNST infusion of CGRP, as did virally-mediated siRNA knockdown of CRF expression locally within the BNST. Together, these results suggest that the anxiogenic effects of intra-BNST CGRP may be mediated by CRF from BNST neurons acting at local CRFR1 receptors. Published by Elsevier B.V.
Utilising Deep Learning Models for the Surface Registration Problem in HoloNav
No full textSurface Registration is a registration problem that handles the registration of two similar surfaces. In most research that utilises Deep Learning (DL) models to handle surface registration two theories are investigated; the first being whether surfaces sampled from the same origin can be registered together, and the second theory being whether the models can register Point Clouds with low overlapping data for utilisation in Simultaneous Localisation and Mapping (SLAM) applications. However, the surface registration to be utilised in the HoloNav Augmented Reality (AR) navigation system will utilise Point Clouds sampled from different origins with a high overlap ratio. This research, therefore, aims to determine the viability of DL methods for surface registration in HoloNav data. To determine the viability, rotation and translation errors in the match were used, with the aforementioned metrics later being evaluated manually with the utilisation of a visualiser. The results indicate that the models can generalise on the navigator data for an initial Euler angle difference of 45 degrees, but due to the difference in sampling density on the utilised point clouds can not provide accurate matches. Therefore, the utilisation of DL models can be considered to be viable if the navigator data has a sampling density similar to the pre-operative model.https://github.com/alpcicimen/holonav-dl-registration The link to the github repository containing the utilised dataset, scripts, as well as the modified DL models RPMNet and PREDATOR.CSE3000 Research ProjectComputer Science and Engineerin
The Scent of a Smell: An Extensive Comparison between Textual and Structural Smells
No full textCode smells are symptoms of poor design or implementation choices that have a negative effect on several aspects of software maintenance and evolution, such as program comprehension or change- and fault-proneness. This is why researchers have spent a lot of effort on devising methods that help developers to automatically detect them in source code. Almost all the techniques presented in literature are based on the analysis of structural properties extracted from source code, although alternative sources of information (e.g., textual analysis) for code smell detection have also been recently investigated. Nevertheless, some studies have indicated that code smells detected by existing tools based on the analysis of structural properties are generally ignored (and thus not refactored) by the developers. In this paper, we aim at understanding whether code smells detected using textual analysis are perceived and refactored by developers in the same or different way than code smells detected through structural analysis. To this aim, we set up two different experiments. We have first carried out a software repository mining study to analyze how developers act on textually or structurally detected code smells. Subsequently, we have conducted a user study with industrial developers and quality experts in order to qualitatively analyze how they perceive code smells identified using the two different sources of information. Results indicate that textually detected code smells are easier to identify and for this reason they are considered easier to refactor with respect to code smells detected using structural properties. On the other hand, the latter are often perceived as more severe, but more difficult to exactly identify and remove.Accepted Author ManuscriptSoftware Engineerin
Oral glucose tolerance test (OGTT: mg/dL) and area under the curve (AUC) of rats fed the control diet non-inoculated (C), diet added with xanthan gum non-inoculated (XG), control diet inoculated with Walker 256 tumor cells (TC) and diet added with xanthan gum inoculated with Walker 256 tumor cells (TXG) after 7 days of inoculation and 8 hours fast.
No full textOral glucose tolerance test (OGTT: mg/dL) and area under the curve (AUC) of rats fed the control diet non-inoculated (C), diet added with xanthan gum non-inoculated (XG), control diet inoculated with Walker 256 tumor cells (TC) and diet added with xanthan gum inoculated with Walker 256 tumor cells (TXG) after 7 days of inoculation and 8 hours fast.</p
Atlas of India /
No full textRelief shown by hachures and spot heights.Title from cover.Maps dated from 1827 to 1862.Sheets from 1827-1836 published by James Horsburgh.Each sheet includes names of individual surveyors, etc., e.g., sheet 4, Cptn. J.T. Walker, Bombay Engrs. & assistants, surveyors.Phillips, 5301Vol. 1. North. Sheet 4, 1862 -- Sheet 14, 1860 -- Sheet 15, 1860 -- Sheet 46, 1861 -- Sheet 47, 1859 -- Sheet 48, 1861 -- Sheet 49, 1848 -- Sheet 50, 1858 -- Sheet 65, 1860 -- Sheet 66, 1827 -- Sheet 67, 1854 -- Sheet 68, 1848 -- Sheet 69, 1849 -- Sheet 70, 1849 -- Sheet 87, 1861 -- Sheet 88, 1853 -- Sheet 89, 1849 -- Sheet 102, 1857 -- Sheet 103, 1857 -- Sheet 104, 1860 -- Sheet 111, 1857 -- Sheet 112, 1857 -- Sheet 113, 1859 -- Sheet 114, 1859 -- Sheet 124, 1830 -- Sheet 125, 1830 -- Sheet 129, 1830 -- Sheet 130, 1830 -- Sheet 131, 1829 -- Sheet 138, 1830.Vol. 2. South. Sheet 24, 1857 -- Sheet 25, 1854 -- Sheet 26, 1852 -- Sheet 38, 1857 -- Sheet 39, 1855 -- Sheet 40, 1852 -- Sheet 41, 1852 -- Sheet 42, 1827 -- Sheet 43, 1827 -- Sheet 44, 1833 -- Sheet 54, 1856 -- Sheet 55, 1855 -- Sheet 56, 1845 -- Sheet 57, 1854 -- Sheet 58, 1827 -- Sheet 59, 1828 -- Sheet 60, 1828 -- Sheet 61, 1833 -- Sheet 62, 1840 -- Sheet 63, 1829 -- Sheet 72, 1836 -- Sheet 73, 1856 -- Sheet 74, 1855 -- Sheet 75, 1842 -- Sheet 76, 1842 -- Sheet 77, 1842 -- Sheet 78, 1828 -- Sheet 79, 1846 -- Sheet 80, 1828 -- Sheet 81, 1828 -- Sheet 94, 1842 -- Sheet 95, 1828 -- Sheet 107, 1846 -- Sheet 108, 1840 -- Sheet 109, 1836 -- Sheet 115, 1862 -- Sheet 116, 1861.Index map sectioned and attached to p. 2 of cover of both volumes. DL
March dl: Adding Adaptive Heuristics and a New Branching Strategy
No full textWe introduce the march dl satisability (SAT) solver, a successor of march eq. The latter was awarded state-of-the-art in two categories during the Sat 2004 competition. The focus lies on presenting those features that are new in march dl. Besides a description, each of these features is illustrated with some experimental results. By extending the pre-processor, using adaptive heuristics, and by using a new branching strategy, march dl is able to solve nearly all benchmarks faster than its predecessor. Moreover, various instances which were beyond the reach of march eq, can now be solved - relatively easily - due to these new features.Software TechnologyElectrical Engineering, Mathematics and Computer Scienc
Atlas of the city of New Bedford, Massachusetts : based on plans in the office of the city engineer.
No full textLeGear. Atlases of the United States, 4925Includes index.LC copy imperfect: Minor damage to plate 25. DL
Crash Reproduction Using Helper Objectives
No full textEvolutionary-based crash reproduction techniques aid developers in their debugging practices by generating a test case that reproduces a crash given its stack trace. In these techniques, the search process is typically guided by a single search objective called Crash Distance. Previous studies have shown that current approaches could only reproduce a limited number of crashes due to a lack of diversity in the population during the search. In this study, we address this issue by applying Multi-Objectivization using Helper-Objectives (MO-HO) on crash reproduction. In particular, we add two helper-objectives to the Crash Distance to improve the diversity of the generated test cases and consequently enhance the guidance of the search process. We assessed MO-HO against the single-objective crash reproduction. Our results show that MO-HO can reproduce two additional crashes that were not previously reproducible by the single-objective approach.Virtual/online event due to COVID-19 Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Software EngineeringSoftware Technolog
A General Formulation to Describe Empirical Rainfall Thresholds for Landslides
No full textAbstractIn this paper, a brief description of the Generalized FLaIR Model (GFM, De Luca and Versace, 2016) is provided, that is able to reproduce all the empirical thresholds proposed in literature, aimed to forecast landslides triggered by rainfall. In particular, this paper focuses on Antecedent Precipitation (AP) schemes. The paper demonstrates that these are particular solutions of the GFM and will exemplify this using AP schemes for NE Italy1, Seattle2 and Nicaragua - El Salvador3
Releasing Fast and Slow: An Exploratory Case Study at ING
No full textThe appeal of delivering new features faster has led many software projects to adopt rapid releases. However, it is not well understood what the effects of this practice are. This paper presents an exploratory case study of rapid releases at ING, a large banking company that develops software solutions in-house, to characterize rapid releases. Since 2011, ING has shifted to a rapid release model. This switch has resulted in a mixed environment of 611 teams releasing relatively fast and slow. We followed a mixed-methods approach in which we conducted a survey with 461 participants and corroborated their perceptions with 2 years of code quality data and 1 year of release delay data. Our research shows that: rapid releases are more commonly delayed than their non-rapid counterparts, however, rapid releases have shorter delays; rapid releases can be beneficial in terms of reviewing and user-perceived quality; rapidly released software tends to have a higher code churn, a higher test coverage and a lower average complexity; challenges in rapid releases are related to managing dependencies and certain code aspects, e.g. design debt.Software EngineeringSoftware Technolog
- …
