28 research outputs found
Propuesta gastronómica para la elaboración de macarons con base en: harina de chulpi (Zea mays sacchara), semillas de sambo (Cucurbita ficifolia) y semillas de zapallo (Cucurbita máxima) con rellenos de dulces y bebidas tradicionales del Azuay
No full textEl macaron es un representante de la repostería fina francesa, un bocadito muy apetecido
por diferentes países del mundo, por este motivo el siguiente trabajo de titulación busca,
mediante el uso de harinas de: chulpi (tostado), semillas de sambo y zapallo, la innovación
de los tradicionales macarons con rellenos de dulces y bebidas tradicionales del Azuay. Se
investigará las principales características organolépticas de cada una de las semillas, sus
beneficios para la salud, sus propiedades organolépticas, vitaminas, minerales y el consumo
de macarons en la ciudad de Cuenca, también su nivel de aceptación en el público mediante
una encuesta realizada en la facultad de ciencias de la hospitalidad. Se elaboraron fichas técnicas tanto de los macarons como de los rellenos y tomando en cuentas las características de cada dulce o bebida tradicional del Azuay se asignó un diferente tipo relleno para cada tipo de macaron. Se realizó pruebas error; la primera consistió en agregar un porcentaje de la harina de almendras en la elaboración del macaron, la segunda, es en donde se utilizó las harinas de chulpi, pepa de sambo y zapallo al 100% en la elaboración del macaron, hemos analizado y
detallado cada resultado de manera escrita y visual para que se pueda comprender el proceso
que ha tenido cada tipo de macaron. Finalmente, al culminar el presente trabajo presentamos recetas estándar de cada tipo de macaron con su respectivo relleno de bebidas y dulces tradicionales del Azuay.
Palabras claves: macarons, semillas, chulpi, sambo, zapalloThe macaron is a representative of French fine pastry, a snack highly desired by different
countries of the world, for this reason the following title work seeks, through the use of flours
of: toasted chulpi, sambo seeds and pumpkin, the innovation of traditional macarons with
fillings of sweets and traditional drinks of Azuay. The main organoleptic characteristics of each
of the seeds will be investigated, their health benefits, organoleptic properties, vitamins,
minerals, the consumption of macarons in the city of Cuenca, their level of acceptance in the
public through a survey carried out in the Faculty of Hospitality Sciences. Technical sheets
were prepared for both the macarons and the fillings and, taking into account the
characteristics of each traditional sweet or drink of Azuay, a different type of filling was
assigned for each type of macaron. Trial and error was performed; The first consisted of
adding a percentage of the almond flour in the preparation of the macaron, the second is
where the chulpi flour, sambo seed and 100% pumpkin were used in the preparation of the
macaron, we have analyzed and detailed each result in a written and visual way so that the
process that each type of macaron has had can be understood. Finally, at the end of this work,
we present standard recipes for each type of macaron with their respective filling of traditional
drinks and sweets from Azuay.
Author Keywords: macarons, seeds, chulpi, sambo, pumpkin, macaronage0000-0003-2080-047
Liquid biopsies and minimal residual disease in lymphoid malignancies
No full textMinimal residual disease (MRD) assessment using peripheral blood instead of bone marrow aspirate/biopsy specimen or the biopsy of the cancerous infiltrated by lymphoid malignancies is an emerging technique with enormous interest of research and technological innovation at the current time. In some lymphoid malignancies (particularly ALL), Studies have shown that MRD monitoring of the peripheral blood may be an adequate alternative to frequent BM aspirations. However, additional studies investigating the biology of liquid biopsies in ALL and its potential as an MRD marker in larger patient cohorts in treatment protocols are warranted. Despite the promising data, there are still limitations in liquid biopsies in lymphoid malignancies, such as standardization of the sample collection and processing, determination of timing and duration for liquid biopsy analysis, and definition of the biological characteristics and specificity of the techniques evaluated such as flow cytometry, molecular techniques, and next generation sequencies. The use of liquid biopsy for detection of minimal residual disease in T-cell lymphoma is still experimental but it has made significant progress in multiple myeloma for example. Recent attempt to use artificial intelligence may help simplify the algorithm for testing and may help avoid inter-observer variation and operator dependency in these highly technically demanding testing process
Episode 6: Navigating Arctic Ambitions - Frozen Water & Warming Seas
No full textGuests Dr. Lawson Brigham and Dr. Rebecca Pincus join host Col. Dave Brown and co-host Dr. Walter Berbrick to discuss the growing importance of the Arctic Sea as an area of economic resources, Trans-Arctic shipping routes, and a potential zone of international security concerns. This episode will touch upon items relating to the Arctic Council, Arctic development, the impact of the Russia-Ukraine War, and a new era of peace and security in the region. Tune in to hear our participants’ thoughts on threat activity in the High North, along with the need for increased strategic considerations and updated U.S. policy directions.
Articles: New Challenges for the Bering Strait, L. Brigham, USNI Proceedings Vol.150/5/1,455, May 2024. Polar Points No. 27 | New Era of Arctic Cooperation, L. Brigham & R. Pincus, Wilson Center, 4 Apr. 2024. 360° View of Policies Needed to Secure Shipping Chokepoints, M. Kennedy, J. Macaron, Wilson Center, et al. (R. Pincus, co-author), 13 Feb. 2024. The IMO Polar Code: Safety and Environmental Protection for Polar Waters, L. Brigham, USNI Proceedings Vol.150/1/1,451, Jan. 2024. Agency Challenges and Implications with a US Extended Continental Shelf, L. Brigham, Wilson Center, 19 Dec. 23. Polar Institute Director Rebecca Pincus on \u27What Is Strategic Competition?\u27, R. Pincus, Wilson Center, 5 Jan. 2024. Arctic Militarization and Russian Military Theory, M. Petersen & R. Pincus, Orbis, Volume 65, Issue 3, 2021, Pages 490-512. Security and geopolitics in the Arctic: The Increase of Hybrid Threat Activities in the Norwegian High North, G. H. Gjorv, Hybrid CoE, March 2024. 400+ Allied, Joint Special Operations Forces Secure the Arctic, M. Carey, DVIDS, 14 Mar. 2024.
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Co-Host:
Walter Berbrick, Ph.D. Senior national security executive, strategist, and advisor with two decades of experience leading teams in policy, intelligence, military and academic communities at the highest levels of government. He currently serves as an analyst in the War Gaming Department in the U.S. Naval War College, and was a previous professor at the college. Walter has held national security roles at the State Department and Pentagon and served for 10 years in the U.S. Navy.
Guests:
Lawson W. Brigham, Ph.D. Global Fellow in the Wilson Center\u27s Polar Institute in Washington, DC. He is a researcher at the University of Alaska Fairbanks and a Fellow at the U.S. Coast Guard Academy\u27s Center for Arctic Study & Policy. Captain Brigham was a career Coast Guard officer and commanded four cutters including the icebreaker Polar Sea on Arctic & Antarctic expeditions. During 2004-09 he was chair of the Arctic Council\u27s Arctic Marine Shipping Assessment. He is a graduate of the Coast Guard Academy and earned his PhD at Cambridge University. Dr. Brigham is a Council on Foreign Relations member and a former member of the National Academies Polar Research Board.
Rebecca Pincus, Ph.D. Director of the Polar Institute at the Wilson Center, and previously on the faculty at the U.S. Naval War College, where her research focused on Arctic security and geopolitics. Dr. Pincus also worked in the Office of the Secretary of Defense for Policy, as an Arctic and Climate Strategy Advisor. A Fulbright Fellow in Iceland, conducting research on Arctic states and security, she was previously on the faculty at the Coast Guard Academy and worked on polar policy for the U.S. Coast Guard, at the Center for Arctic Study and Policy. Widely published and a contributing author for the 5th National Climate Assessment, she has also testified before Congress and the U.S.-China Commission on security and defense in the polar regions.https://digital-commons.usnwc.edu/the-trident/1005/thumbnail.jp
S118: A CHEMOTHERAPY-FREE COMBINATION OF PONATINIB AND BLINATUMOMAB FOR PATIENTS WITH NEWLY DIAGNOSED PHILADELPHIA CHROMOSOME-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA: SUBGROUP ANALYSIS FROM A PHASE II STUDY
No full textP358: HYPER-CVAD WITH BLINATUMOMAB AND INOTUZUMAB OZOGAMICIN FOR PATIENTS WITH NEWLY DIAGNOSED PHILADELPHIA CHROMOSOME-NEGATIVE B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA: A PHASE II STUDY
No full textP373: UPDATES FROM A PHASE II TRIAL OF MINI-HYPER-CVD-INOTUZUMAB WITH OR WITHOUT BLINATUMOMAB IN OLDER PATIENTS WITH NEWLY DIAGNOSED PHILADELPHIA CHROMOSOME (PH)-NEGATIVE ACUTE LYMPHOBLASTIC LEUKEMIA
No full textArgileh smoking among university students: A new tobacco epidemic
No full textThe recent global increase in argileh use represents the modern renaissance of an old public health threat and a new tobacco epidemic. This study examined argileh smoking knowledge and attitudes in a sample of university students in Beirut as determinants of argileh smoking. Data were collected cross-sectionally through self-administered questionnaires from 416 students at the American University of Beirut through stratified cluster sampling. The proportion of ever-smokers in this study was 43percent, compared with the 30percent reported 4 years ago. A total of 28.3percent of the surveyed students were current argileh smokers, and the average initiation age was 16 years. Compared with argileh smokers, significantly greater proportions of nonsmokers had positive attitudes about argileh banning and more accurate knowledge about argileh. Argileh smoking among Lebanese young is on the rise. Students demonstrated partial knowledge and moderate to favorable attitudes concerning argileh smoking. Possible public health interventions are discussed in light of the social and cultural context of argileh use to neutralize this emerging global public health threat. © 2004 Society for Research on Nicotine and Tobacco.Abolfotouh MA, 1998, ANN SAUDI MED, V18, P212; Abolfotouh M.A., 1997, E MEDITERRANEAN HLTH, V3, P90; ALFAYEZ SF, 1988, TROP GEOGR MED, V40, P115; ALI A, 2001, GULF NEWS; Chaaya Monique, 2003, Matern Child Health J, V7, P179, DOI 10.1023-A:1025136421230; *CTR REV DISS, 1998, EFF MATTERS 3; El-Hakim IE, 1999, INT J DERMATOL, V38, P108, DOI 10.1046-j.1365-4362.1999.00448.x; FIKRI M, 2002, REPORT RESULTS GLOBA; GODFREY C, 1988, BRIT MED J, V297, P339; Kandela P, 1997, LANCET, V349, P1460, DOI 10.1016-S0140-6736(05)63750-6; Kandela P, 2000, LANCET, V356, P1175, DOI 10.1016-S0140-6736(05)72871-3; Kiter G, 2000, RESP MED, V94, P891, DOI 10.1053-rmed.2000.0859; Macaron C I, 1997, J Med Liban, V45, P46; MCNICOLL T, 2002, NEWSWEEK INT, V140, P60; *NAT SMOK CONTR PR, 2003, HLTH PROM BOARD; Nuwayhid IA, 1998, AM J EPIDEMIOL, V148, P375; RADWAN A, 1999, TIME INT, V153, P42; Sajid Khan Mohammad, 1993, JPMA (Journal of the Pakistan Medical Association), V43, P179; SHEDIACRIZKALLA.M, 2001, INT Q COMMUNITY HLTH, V20, P115, DOI 10.2190-UM5G-3EJN-NAC1-FG8J; Shihadeh A, 2003, FOOD CHEM TOXICOL, V41, P143, DOI 10.1016-S0278-6915(02)00220-X; SOWDEN AJ, 1998, COCHRAN LIB; *SRI INT, 2000, LEB HIGH VAL ADD AGR; TOWNSEND J, 1994, BRIT MED J, V309, P923; U.K. Department of Health, 1992, EFF TOB ADV TOB CONS; ZAHRAN F, 1982, AM J PUBLIC HEALTH, V72, P722, DOI 10.2105-AJPH.72.7.72254484
P364: A PHASE II STUDY OF LOW-INTENSITY CHEMOTHERAPY (MINI-HYPER-CVD) AND PONATINIB FOLLOWED BY BLINATUMOMAB AND PONATINIB IN PATIENTS WITH PHILADELPHIA CHROMOSOME-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA
No full text‐negative remission
No full textRecurrence of MRD in AML is associated with imminent relapse unless intervened upon. Change in chemotherapy regimen and/or immediate transplant improve outcomes
mutations according to frontline therapy in patients with acute myeloid leukemia
No full textRUNX1-mutated (mRUNX1) acute myeloid leukemia (AML) has historically been associated with poor outcomes in the setting of conventional chemotherapy. The prognostic impact of mRUNX1 AML is not well-established in the current era of lower-intensity treatment regimens incorporating venetoclax. We retrospectively analyzed 907 patients with newly diagnosed AML, including 137 patients with mRUNX1 AML, who underwent first-line therapy with intensive chemotherapy (IC), low-intensity therapy without venetoclax (LIT without VEN), or LIT with VEN. When stratified by RUNX1 status, there was no statistically significant difference in outcomes between mRUNX1 and wild-type (wtRUNX1) AML, regardless of therapy received. However, among patients who received LIT with VEN, there was a trend towards superior overall survival (OS) in those with mRUNX1 AML (median OS for mRUNX1 vs. wtRUNX1: 25.1 vs. 11.3 months; 2-year OS 54% vs. 33%; p = 0.12). In patients without another adverse-risk cyto-molecular feature, the presence of mRUNX1 conferred inferior OS in patients who received IC (p = 0.02) or LIT without VEN (p = 0.003) but not in those who received LIT with VEN (mRUNX1 vs. wtRUNX1: 25.1 vs. 30.0 months; 2-year OS 59% vs. 54%; p = 0.86). A multivariate analysis showed possible interaction between RUNX1 mutation status and treatment, suggesting a differential prognostic impact of RUNX1 mutations when patients received IC versus LIT with VEN. In summary, the prognostic impact of mRUNX1 AML may be treatment-dependent, and the presence of RUNX1 mutations may not impact clinical outcomes when venetoclax-based regimens are used
