16 research outputs found
Effect of miswak extract on healthy human dentin an in vitro study
No full textThe purpose of this study was to compare the texture of dentin surfaces after the application of saline, aqueous and alcohol-derived miswak extracts using different modes of application and exposure times. It was concluded that alcohol derived miswak extract at pH of 2.5 to 2.9, selectively removed the smear layer from the dentin surface exposing the dentinal tubules. This result was in contrast to burnishing dentin surface with aqueous - miswak extract of higher pH 6.3 to 6.6 or with saline, both of which partially removed the smear layer without dentinal tubules exposure. It cannot be excluded that the pH of the solutions used is an important factor in determining whether etching occurs.Corresponding Author:
Dr. Nadir Babay, Division of Periodontics, Department of Preventive Dental Sciences, College of Dentistry, King Saud University, PO Box 60169, Riyadh 11545, K.S.A. Email: [email protected]
The effect of EDTA on the attachment and growth of cultured human gingival fibroblasts on periodontitis-affected root surface
No full textThe purpose of the present study was to analyze the effects of 5% and 24% EDTA on the attachment of gingival fibroblasts to periodontally diseased root surfaces. A flat root surface was created on human teeth that were extracted due to severe periodontitis. The teeth were etched with the following concentrations of etylediaminetetraacetic acid (EDTA) for two minutes: 5% (group I) and 24% (group II). Group III was soaked in saline and served as a control. The specimens and fibroblasts were incubated in a culture medium for 24 hours each day for one and two weeks and photographed using scanning electron microscopy. Each specimen was examined for the migration of cells into the etched and non-etched root surface. No fibroblasts could be detected on the saline groups. More fibroblasts could attach to the surface treated with 24% EDTA than with 5% EDTA. It was concluded that supersaturated EDTA at 24% enhances the attachment of gingival fibroblasts to the root surface.Corresponding Author:
Dr. Babay Nadir
Associate Professor & Head of the Division of Periodontics, Department of Preventive Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Email: [email protected]
Effect of various scaling and conditioning procedures onperiodontally affected Human root surfaces: a scanning electron microscopic study
No full textThe purpose of the present study was to investigate the appearance of periodontally involved root surfaces after hand scaling and after using two different piezoelectric ultrasonic scalers. Further, the root surfaces were examined by a scanning electron microscope after they have been treated with saline, saturated citric acid, saturated tetracycline hydrochloride or 8% EDTA for 3 minutes. Thirty-seven root specimens from the "diseased" part of nine periodontally-involved human permanent teeth were analyzed after they have been treated according to the above-mentioned procedures with corresponding controls (non-treated) in a randomized order. The observations made indicated no differences among the three scaling devices, but significant differences among etched, or chelated, and non-etched, or non-chelated, root surfaces with the former showing needle-pointed surfaces and crater formations.This study was registered with the College of Dentistry Research Center, Grant No. NF1289.Corresponding Author:
Dr. Nadir Babay, Department of Preventive Dental Sciences, King Saud University College of Dentistry, P.O. Box 60169, Riyadh 11545, Saudi Arabia. Email:[email protected]
The effect of tetracycline hydrochloride on the smear layer formed by various root planing modalities: A scanning electron microscopy study
No full textThe purpose of the present study was to examine the smear layer formation following different root planing modalities and its removal using tetracycline hydrochloride. Thirty-two periodontitis involved human teeth were randomly divided into 8 groups of 4 each.
Groups 1 & 2 were root planed with hand instrument (Gracey 11/12) while in groups 3 & 4, aflat diamond bur was used. In groups 5 & 6, the roots were scaled with a piezoelectric unit (Piezon) while in groups 7 & 8, a magnetostrlctive unit (Amdent) was used. Sixteen teeth (two in each group) were conditioned with tetracycline hydrochloride for 3 minutes while the other sixteen teeth were not conditioned and served as controls. The surfaces were examined by a scanning electron microscope. The results showed that root planing resulted in a smear covering the root surfaces, irrespective of the treatment modality. Tetracycline hydrochloride efficiently removed the smear layer with collagen fibers exposed to varying degrees.Corresponding Author:
Dr. Nadir Babay, Associate Professor, Head of Division of Periodontics
Department of Preventive Dental Sciences
College of Dentistry, King Saud University
PO Box 60169, Riyadh 11545, Saudi Arabia.
Email: [email protected]
Effective and affordable periodontal maintenance therapy
No full textMechanical and chemical antimicrobial intervention is the mainstay of preventive periodontal
therapy. Successful periodontal maintenance care depends upon the ability of dental professionals to combat periodontal infections and patient compliance with prescribed follow-up care. Since tooth brushing, flossing
and oral rinsing do not reach pathogens residing in furcations and at the depths of deep periodontal pockets,
adequate oral hygiene should include subgingival treatment with home irrigators or other appropriate self-care remedies in patients with increased pocket depths. I'ovidonc-iodine for professional use and diluted bleach
for self-care are iue\pensi\e and \aluable antimicrobial agents in periodontal maintenance. The present article outlines the prudent use of antimicrobial therapy in periodontal maintenance therapy.Corresponding Author:
Prof Nadir Babay, Associate Professor and Program Director of Postgraduate
Periodontics, Department Preventive Dentistry, College of Dentistry, King Saud University, P.O.Box 60169, Riyadh 11545, Saudi Arabia.
Email: [email protected]
in ovarian carcinoma
No full textHLA-G is a non-classical major histocompatibility complex class Ib molecule. Its expression has been described in various cancer types, including ovarian cancer. HLA-G molecule has been implicated in immune escape and in progression of ovarian tumor cells. Our goal was to assess if total soluble (s)HLA-G molecules or HLA-G5 and sHLA-G1 isoforms could be considered as circulating ovarian tumor biomarkers, we measured the concentration of these molecules in ovarian carcinoma patients stratified according with their clinicopathological parameters. sHLA-G, sHLA-G1 and HLA-G5 concentrations were dosed in plasma samples by sandwich-ELISA. The sHLA-G dimerization was analyzed after immunoprecipitation and SDS-PAGE migration. Total sHLA-G and sHLA-G1 levels were significantly represented in plasma of ovarian carcinoma patients compared to healthy controls. sHLA-G1 isoform concentration was highly represented in ovarian carcinoma compared to HLA-G5 isoforms. Additionally, high sHLA-G molecules have been found in aged patients, as well as in patients with advanced stages, and those with metastatic lymph nodes and those with distant metastasis. Elsewhere, sHLA-G monomers were highly represented in ovarian carcinoma patients compared to controls. sHLA-G plasmatic protein was highly represented in ovarian carcinoma. In effect, HLA-G might be considered as a new checkpoint molecule that could be used to assess progression and recurrence of the disease, thus placing it as a potential biomarker for advanced and complicated ovarian carcinoma
Increased levels of soluble HLA-G molecules in Tunisian patients with chronic hepatitis B infection
No full textHepatitis B virus (HBV) infection is a global health problem. The mechanisms of immune tolerance in HBV infection are still unclear. The host immune response plays a critical role in determining the outcome of HBV infection. Human leucocyte antigen-G (HLA-G) is involved in immunotolerogenic process and infectious diseases. This study aimed to explore the implication of soluble HLA-G (sHLA-G) and its isoforms in HBV infection. Total sHLA-G (including shedding HLA-G1 and HLA-G5) was analysed by ELISA in 95 chronic HBV patients, 83 spontaneously resolvers and 100 healthy controls (HC). To explore the presence of sHLA-G dimers, we performed an immunoprecipitation and a Western blot analysis on positive samples for sHLA-G in ELISA. The serum levels of sHLA-G were significantly increased in patients with chronic HBV patients compared to spontaneously resolvers and HC (P<.0001). Interestingly, we found an increased level of sHLA-G1 in chronic HBV patients than in spontaneously resolvers and HC (P<.001). In addition, the expression of HLA-G5 seems to be higher in the sera of chronic HBV patients than spontaneously resolvers (P=.026). The analysis of HLA-G dimers showed the presence of homodimers in 93% of chronic HBV patients, 67% in spontaneously resolvers and 60% in HC. These results provide evidence that sHLA-G may have a crucial role in the outcome of HBV infection and could be proposed as a biomarker for infection outcome. Based on its tolerogenic function, HLA-G might be considered as a new promising immunotherapeutic approach to treat the chronic infection with HBV
The nature of soft tissue attachment with acid-enzyme treated roots :
No full textPLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please log in with a valid BU account to access and click Download. If you are the author of this work and would like to make it publicly available, please contact [email protected] photographs included.Thesis (M.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1981 (Oral biology)Bibliography : leaves 124-147
HLA‐G, HLA‐E, and IDO overexpression predicts a worse survival of Tunisian patients with vulvar squamous cell carcinoma
No full textThe storytelling of İbrahim Gazi
No full textİbrahim Gazi'nin Hikâyeciliği adlı bu tezde Modern Tatar hikâyeciliğinin önemli isimlerinden biri olan İbrahim Gazi'nin Türk edebiyatında tanıtılması ve hikâyelerinde kullandığı yapı unsurlarının incelenerek onun edebiyat dünyasındaki konumu ve öneminin belirlenmesi amaçlanmıştır. Çalışmada yazarın kaleme aldığı yirmi sekiz hikâye Türkiye Türkçesine aktarılarak kurgu, içerik, anlatıcı ve bakış açısı, kişiler, mekân, zaman, dil ve üslup ve anlatım teknikleri gibi teknikler ışığında ele alınmıştır. Bu doğrultuda ilk olarak Gazi'nin hayatı, edebî kişiliği ve eserleriyle hakkında bilgi verilmiştir. Yazarın eserlerinin geneline bakıldığında öz yaşam öyküsünün hikâyelerinin merkezinde yer aldığı görülmüştür. Özellikle, II. Dünya Savaşı sırasında yazarın sanatı yeni bir boyut kazanmış ve bu yıllarda kalemini ustalaştıran yazar, savaş sonrası dönemde sanatının zirvesine ulaşmıştır. Dönemin ruhunu yansıtan Sıyırcıklar (Sığırcıklar) Yugalgan Marziye (Kaybolan Marziye), Ana (Anne) Kışkı Kiçte (Kış Akşamında), Malay bilen Et (Çocuk ile Köpek), Aksöyek Nemetslar hem Kazlar (Soylu Almanlar ve Kazlar) ve Ehmet Babay (Ahmet Dede) gibi hikâyelerinde Tatar toplumunun savaş zamanı yaşadığı acıları, bu acıların yarattığı travmanın insanlar üzerinde nefret ve intikam duygularını çağrıştırdığını gözler önüne sermiştir. Aynı zamanda Yul Östindegi Taş (Yol Üstündeki Taş) ve Ni öçin Töymeni Ozak Tagalar? (Neden Düğmeyi Uzun Sürede Takıyorlar?) hikâyelerinde birçok yazarın kaleme almaya bile cesaret edemediği dönemin başlıca sorunlarına değinmiştir. Ak Sirin (Beyaz Leylak), Turgay Kartayamı iken? (Turgay Yaşlanıyor mu?), Bibisara, Gevheriye hem Usal At (Bibisara, Gevheriye ve Hırçın At), Yana Mastir (Yeni Usta), Öç Mehmüt (Üç Mahmut) gibi hikâyelerinde ise bireysel konuları işlemiş ve bireyin iç dünyasını çözümlemeye yönelik psikolojik tahlillere yer vermiştir. İbrahim Gazi hikâyelerinde genel olarak birinci şahıs anlatım ve kahraman bakış açısını kullanmıştır. Hikâyelerinde kullandığı mekânlar yazarın bizzat içinde bulunduğu, yakın çevresinde yer alan mekânlardır. Çağının tanığı olan İbrahim Gazi, hikâyelerindeki kişi yaratımları, dili kullanımındaki titizliği ve anlatım teknikleriyle Tatar edebiyatının önemli isimleri arasında yer alır.In this thesis named İbrahim Gazi's Storytelling, it is aimed to introduce İbrahim Gazi, one of the important names of Modern Tatar storytelling, in Turkish literature and to determine his position and importance in the world of literature by examining the structural elements he used in his stories. In the study, twenty-eight stories written by the author were transferred to Turkiye Turkish and discussed in the light of techniques such as fiction, content, narrator and point of view, people, place, time, language and wording and narrative techniques. In this direction, firstly, information was given about Gazi's life, literary personality and works. When the author's works are examined in general, it is seen that his autobiography is at the center of his stories. In particular, during World War II, the author's art has taken on a new dimension and the author who mastered his pen in these years reached the peak of his art in the post-war period. In his stories such as Sıyırcıklar (Sığırcıklar) Yugalgan Marziye (Kaybolan Marziye), Ana (Anne) Kışkı Kiçte (Kış Akşamında), Malay bilen Et (Çocuk ile Köpek), Aksöyek Nemetslar hem Kazlar (Soylu Almanlar ve Kazlar) ve Ehmet Babay (Ahmet Dede) reflecting the spirit of the period, he revealed that the trauma created by these pains evokes feelings of hatred and revenge on people. At the same time, in his stories Yul Östindegi Taş (Yol Üstündeki Taş) ve Ni öçin Töymeni Ozak Tagalar? (Neden Düğmeyi Uzun Sürede Takıyorlar?) he touched upon the main problems of the period that many writers did not even dare to write. In his stories Ak Sirin (Beyaz Leylak), Turgay Kartayamı iken? (Turgay Yaşlanıyor mu?), Bibisara, Gevheriye hem Usal At (Bibisara, Gevheriye ve Hırçın At), Yana Mastir (Yeni Usta), Öç Mehmüt (Üç Mahmut), he dealt with individual subjects and included psychological analyzes to analyze the inner world of the individual. İbrahim Gazi generally used first-person narration and heroic point of view in his stories. The places he used in his stories are the places in his immediate surroundings that the author has personally experienced. İbrahim Gazi, who is a witness of his age, is among the important names of Tatar literature with his personal creations in his stories, meticulousness in the use of language and expression techniques
