94 research outputs found
La cosmétologie à travers les âges
No full textDie Kosmetologie im Laufe der Zeit.
Die Verfasserin gibt eine kurze Übersicht der Kosmetologie vom alten Aegypten an bis zum 19. Jahrhundert.Cosmetology across the ages.
The author paints a quick sketch of cosmetology from Ancient Egypt to the 19th century.de Roeck-Holtzhauer Yannick. La cosmétologie à travers les âges. In: Revue d'histoire de la pharmacie, 76ᵉ année, n°279, 1988. pp. 397-399
« Notte pour faire la pomade pour plusieurs maux » ou la recette d'un guérisseur vendéen
No full text« Notiz zur Bereitung der Salbe für mehrere Gebrechen » oder das Rezept eines Heilkunstlers aus der Vendée.
Der Verfasser untersucht die Zusammensetzung der Formel eines Empirikers aus der Vendée in der zweiten Hälfte des 19. Jahrhunderts fur Flechten, Brandwunden, Frostbeulen und Hamorrhoiden. Er ziecht daraus den Schluss auf Stichhaltigkeit dieser Formel welche der damaligen gebrauchten Polytherapie entspricht.« Notes on How to Make the Pommade for Several Illnesses » or the recipe of a healer from Vendée.
The author examines the composition of a formula from an empiric of Vendée, from the second half of the 19th century, for skin eruptions, burns, chilblains and hemorrhoids. He concludes that the components of the formula are valid, and conform to the polytherapy in use at that time.Romieux Yannick. « Notte pour faire la pomade pour plusieurs maux » ou la recette d'un guérisseur vendéen. In: Revue d'histoire de la pharmacie, 78ᵉ année, n°287, 1990. pp. 449-452
Law & Economics Perspectives on Electricity Regulation
No full textThis paper first reviews some of the main contributions of the new institutional economics to the analysis of the process of competitive transformation of network industries. It shows that neoinstitutional analysis is complementary to the microeconomics of rational pricing, since it accounts for the decisive role of an institutional framework adapted to new transactions. It emphasizes the importance of the political reform process, which draws on the conditions of attractiveness and feasibility to define an initial reorganization of property rights in these industries. The paper then analyzes in this light some of the main challenges ahead for electricity regulation: the question of investment in generation capacities and the link to long term contracts, the regulation of wholesale market power, the support to Renewable Energy Sources for Electricity (RES-E) and the design of new regulatory authorities.Electricity Markets; New Institutional Economics; Law & Economics
D'un pot de pharmacie à la vie d'une famille de pharmaciens vendéens
No full textVon einem Apotheken-Gefäss zur Lebensskizze einer Apotheker-Familie aus der Vendée.
Um einen Salbentopf aus Faience von Creil und Montereau zu datieren und den Apotheker auszumachen dessen Name und Adresse auf dem Gefäss figuriert, sieht sich der Verfasser veranlasst das Leben von François Chassant (1804-1883), Apotheker in La Roche-sur-Yon, aufzuzeichnen. Sein Sohn Auguste wurde sein Nachfolger. Der Topf kann um 1849-1852 datiert werden.From a pharmacy jar to the life of a family of pharmacists from the Vendée.
In order to date a pommade jar of Creil and Montereau faience, and to identify the pharmacist whose name and address it bears, the author was brought to retrace the life of François Chassant (1804-1883), pharmacist of La Roche-sur-Yon, succeeded by his son Auguste. The pot can be dated from 1849-1852.Romieux Yannick. D'un pot de pharmacie à la vie d'une famille de pharmaciens vendéens. In: Revue d'histoire de la pharmacie, 75ᵉ année, n°272, 1987. pp. 57-64
Reprocessing used surgical instruments for veterinary healthcare application: A case study on surgical vessel sealing energy-based devices
No full textWith increasing healthcare demand, environmental concerns and waste management in healthcare, particularly in the operating room (OR), are significant issues. Disposable surgical energy devices, like vessel sealers, gain popularity in veterinary healthcare, but reusing them is officially forbidden by law and presents challenges. Objective: This research aims to clinically validate reprocessing the Ethicon HARMONIC® HD 1000i for safe reuse in veterinary healthcare. The study assesses the feasibility of using readily available disinfection methods and evaluates the device’s functionality and safety. The research’s scope is limited to a case study (functional analysis) on the Ethicon HARMONIC® HD 1000i. Methods: A comprehensive device analysis was performed using Hot Spot Mapping and Disassembly Map methods, followed by mechanical stability testing during sterilization conditions. A design update was proposed for easier disassembly. The functionality of 2x new, 2x reprocessed and 2x redesigned Ethicon HARMONIC® HD 1000i’s after reprocessing (disinfection, disassembly, reassembly, sterilization) was evaluated in a bench-top study. Tissue transsections on 120 cm pork fillets (6-11mm thickness) per device and pinch force measured with newly developed sensor (40 movements/device) were performed. Furthermore, 2 burst pressure measurements per device on frozen and embalmed artery sections were performed in collaboration with Amsterdam Skills Centre for Health Science. Results: In the disassembly analysis, 42 operations were needed, involving 40 parts and 10 steps with 6 tools. The disassembly time was 429 seconds (07:09 minutes) total. In tissue transsection, the new and reprocessed devices performed similarly, with mean task times ranging from 62.3 to 66.8 seconds. The redesigned devices had slower task times (averaging 196.1 seconds and 104.7 seconds) resulting in lower marching speeds (0.5-1.0 mm/s compared to 1.5-1.6 mm/s for new and reprocessed devices). In pinch force measurements the new devices performed best with average pinch forces of 19.1 N and 20.2 N. The reprocessed devices had slightly lower performance (16.8 N and 16.7 N), while the redesigned devices performed the worst with pinch forces of 5.6 N and 8.8 N, representing a significant drop in performance compared to the new devices. The burst pressure measurement tests showed that none of the devices were able to effectively seal the arteries, resulting in no pressure buildup. Discussion: Overall, reprocessed devices performed similarly to new devices in tissue transsection, showing the effectiveness of reprocessing. Achieved marching speeds by reprocessed and redesigned were considerable given tissue thickness differences, highlighting reprocessing’s potential to extend device lifespan. New devices had 15% higher pinch force than reprocessed, while redesigned had 63% lower force due to a weakened casing. Strengthening redesign and adding new jaw ends could improve modularity and power transmission. Burst pressure tests revealed all Ethicon Harmonic devices (new, reprocessed, redesigned) couldn’t effectively sealarteries, likely due to frozen artery characteristics and tissue alterations from embalming. Conclusion: This study emphasized the potential of modular medical devices with improved disassembly time, demonstrating that a modular design approach combined with reprocessing strategies holds promise to ensure a more sustainable healthcare system. This research is a collaboration between the Technical University of Delft, Johnson & Johnson Netherlands and GreenCycl.Keywords: ETHICON, harmonic, ENSEAL, Ligasure, ster- ilisation, reprocessing, medical instruments, healthcare, veterinary, redesign, modular, burst pressure, tissue transection, pinch forceBiomedical Engineerin
Walker-Breaker Games on
No full textThe Maker-Breaker connectivity game and Hamilton cycle game belong to the
best studied games in positional games theory, including results on biased
games, games on random graphs and fast winning strategies. Recently, the
Connector-Breaker game variant, in which Connector has to claim edges such that
her graph stays connected throughout the game, as well as the Walker-Breaker
game variant, in which Walker has to claim her edges according to a walk, have
received growing attention.
For instance, London and Pluh\'ar studied the threshold bias for the
Connector-Breaker connectivity game on a complete graph , and showed that
there is a big difference between the cases when Maker's bias equals or
. Moreover, a recent result by the first and third author as well as Kirsch
shows that the threshold probability for the Connector-Breaker
connectivity game on a random graph is of order
. We extent this result further to Walker-Breaker games and
prove that this probability is also enough for Walker to create a Hamilton
cycle
A (doubly) elementary formula for prime numbers
No full textInternational audienceIn this paper the author gives formulas for the prime counting function and for the n-th prime numbers. These formulas only use elementary functions. Moreover their proof requires only elementary facts of number theory, so that the title of the paper is justified
Coevolution combined with molecular dynamics simulations provides structural and mechanistic insights into the interactions between the integrator complex subunits
No full textFinding the 3D structure of large, multi-subunit complexes is difficult, despite recent advances in cryo-EM technology, due to remaining challenges to expressing and purifying subunits. Computational approaches that predict protein-protein interactions, including Direct Coupling Analysis (DCA), represent an attractive alternative for dissecting interactions within protein complexes. However, they are readily applicable only to small proteins due to high computational complexity and a high number of false positives. To solve this problem, we proposed a modified DCA approach, a powerful tool to predict the most likely interfaces of protein complexes. Since our modified approach cannot provide structural and mechanistic details of interacting peptides, we combine it with Molecular Dynamics (MD) simulations. To illustrate this novel approach, we predict interacting domains and structural details of interactions of two Integrator complex subunits, INTS9 and INTS11. Our predictions of interacting residues of INTS9/INTS11 are highly consistent with crystallographic structure. We then expand our procedure to two complexes whose structures are not well-studied: 1) The heterodimer formed by the Cleavage and Polyadenylation Specificity Factor 100-kD (CPSF100) and 73-kD (CPSF73); 2) The heterotrimer formed by INTS4/INTS9/INTS11. Experimental data supports our predictions of interactions within these two complexes, demonstrating that combining DCA and MD simulations is a powerful approach to revealing structural insights of large protein complexes
NONLOCAL FILTRATION EQUATIONS AND FRACTIONAL CURVATURE FLOWS
No full textIn this thesis, we record the joint work done by the author and Pak Tung Ho concerning the fractional Nirenberg problem with a symmetric assumption, which is addressed through fractional curvature flows on the Riemannian sphere Sn. Furthermore, we present the author’s work on nonlocal filtration equations related to the Heisenberg group Hn. The classical Nirenberg’s problem is to find a conformal metric of an n-dimensional Riemannian manifold such that its scalar curvature is a given function f. A geometric flow has been introduced to study Nirenberg’s problem by Struwe for n = 2 and has been generalized to n ≥ 3 by Chen and Xu on the sphere Sn. Using the scalar curvature flow, Leung and Zhou proved an existence result for prescribing scalar curvature when the given function f possesses certain reflection or rotation symmetry on the Riemannian sphere Sn in their paper. This led naturally to the study of the prescribing fractional order curvature problem with the same symmetric hypothesis on Sn, which has been proved by the author and Pak Tung Ho. Motivated by the extensive investigations of nonlocal filtration equations, utilizing the integral operators instead of the Laplacian operator on the Euclidean space Rn, we work on the same type of equations on the Heisenberg group Hn. We established the existence, uniqueness and large-time behavior of the corresponding solutions. Furthermore, an interesting result stated that a uniform Hölder regularity, as the function value tends to zero, holds for the porous medium type of equations, which can also be adapted to obtain uniform Hölder regularity on Rn
NONLOCAL FILTRATION EQUATIONS AND FRACTIONAL CURVATURE FLOWS
No full textIn this thesis, we record the joint work done by the author and Pak Tung Ho concerning the fractional Nirenberg problem with a symmetric assumption, which is addressed through fractional curvature flows on the Riemannian sphere Sn. Furthermore, we present the author’s work on nonlocal filtration equations related to the Heisenberg group Hn. The classical Nirenberg’s problem is to find a conformal metric of an n-dimensional Riemannian manifold such that its scalar curvature is a given function f. A geometric flow has been introduced to study Nirenberg’s problem by Struwe for n = 2 and has been generalized to n ≥ 3 by Chen and Xu on the sphere Sn. Using the scalar curvature flow, Leung and Zhou proved an existence result for prescribing scalar curvature when the given function f possesses certain reflection or rotation symmetry on the Riemannian sphere Sn in their paper. This led naturally to the study of the prescribing fractional order curvature problem with the same symmetric hypothesis on Sn, which has been proved by the author and Pak Tung Ho. Motivated by the extensive investigations of nonlocal filtration equations, utilizing the integral operators instead of the Laplacian operator on the Euclidean space Rn, we work on the same type of equations on the Heisenberg group Hn. We established the existence, uniqueness and large-time behavior of the corresponding solutions. Furthermore, an interesting result stated that a uniform Hölder regularity, as the function value tends to zero, holds for the porous medium type of equations, which can also be adapted to obtain uniform Hölder regularity on Rn
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