824 research outputs found

    Sex differences in the prediction of the effectiveness of paroxetine for patients with major depressive disorder identified using a receiver operating characteristic curve analysis for early response [Corrigendum]

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    Tomita T, Norio YF, Sato Y, et al. Neuropsychiatr Dis Treat. 2014;10:599–606.On page 599, there is an error in the author list "Yasui-Furukori Norio" should read "Norio Yasui-Furukori".Read the original articl

    Lipids in the Structure of Photosystem I, Photosystem II and the Cytochrome b6f Complex

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    This chapter describes the data accumulated in the last decade regarding the specific function of lipids in oxygenic photosynthesis,based on crystal structures of at least 3.0 Å resolution of the main photosynthetic membrane protein—pigment complexes, photosystemI, photosystem II and cytochrome b6f. Comparisons with other structures of membrane protein complexes like the bacterial reaction center and the external antennasystem from the plant light harvesting complexes II reveal the functional versatility of integral lipids. A detailed structuraldescription of the membrane protein complexes pinpoints the various interactions of integral lipids between protein and pigments(e.g., chlorophylls, carotenoids, quinones) and gives a deep insight into their functional roles. A particular focus in thischapter is on the lipid-filled plastoquinone exchange cavities in photosystem II and cytochrome b6f. The differences in extent and lipophilic character of these cavities will be discussed in the light of the resulting plastoqui-none/plastoquinolexchange mechanism. An exceptional feature of PS II is the water splitting reaction enabled by the Mn4Ca cluster. This results in the release of protons to the lumenal aqueous phase, release of electrons to a chain of acceptors,which provides metabolically available reduction equivalents, and release of dioxygen to the atmosphere. The high contentof lipids in the interior of photosystem II will be correlated with possible diffusion pathways of the dioxygen and the turnoverof the D1 protein, necessary to counteract the photodamage occurring within photosystem II. More structural details of integrallipids derived from higher resolution data from these remarkable membrane protein complexes in combination with data frommutant and/or spectroscopic studies will lead to extended functional insights in the future.<br/

    Lipids in the Structure of Photosystem I, Photosystem II and the Cytochrome b6f Complex

    No full text
    This chapter describes the data accumulated in the last decade regarding the specific function of lipids in oxygenic photosynthesis,based on crystal structures of at least 3.0 Å resolution of the main photosynthetic membrane protein—pigment complexes, photosystemI, photosystem II and cytochrome b6f. Comparisons with other structures of membrane protein complexes like the bacterial reaction center and the external antennasystem from the plant light harvesting complexes II reveal the functional versatility of integral lipids. A detailed structuraldescription of the membrane protein complexes pinpoints the various interactions of integral lipids between protein and pigments(e.g., chlorophylls, carotenoids, quinones) and gives a deep insight into their functional roles. A particular focus in thischapter is on the lipid-filled plastoquinone exchange cavities in photosystem II and cytochrome b6f. The differences in extent and lipophilic character of these cavities will be discussed in the light of the resulting plastoqui-none/plastoquinolexchange mechanism. An exceptional feature of PS II is the water splitting reaction enabled by the Mn4Ca cluster. This results in the release of protons to the lumenal aqueous phase, release of electrons to a chain of acceptors,which provides metabolically available reduction equivalents, and release of dioxygen to the atmosphere. The high contentof lipids in the interior of photosystem II will be correlated with possible diffusion pathways of the dioxygen and the turnoverof the D1 protein, necessary to counteract the photodamage occurring within photosystem II. More structural details of integrallipids derived from higher resolution data from these remarkable membrane protein complexes in combination with data frommutant and/or spectroscopic studies will lead to extended functional insights in the future.<br/

    Lipids in the Structure of Photosystem I, Photosystem II and the Cytochrome b6f Complex

    No full text
    This chapter describes the data accumulated in the last decade regarding the specific function of lipids in oxygenic photosynthesis,based on crystal structures of at least 3.0 Å resolution of the main photosynthetic membrane protein—pigment complexes, photosystemI, photosystem II and cytochrome b6f. Comparisons with other structures of membrane protein complexes like the bacterial reaction center and the external antennasystem from the plant light harvesting complexes II reveal the functional versatility of integral lipids. A detailed structuraldescription of the membrane protein complexes pinpoints the various interactions of integral lipids between protein and pigments(e.g., chlorophylls, carotenoids, quinones) and gives a deep insight into their functional roles. A particular focus in thischapter is on the lipid-filled plastoquinone exchange cavities in photosystem II and cytochrome b6f. The differences in extent and lipophilic character of these cavities will be discussed in the light of the resulting plastoqui-none/plastoquinolexchange mechanism. An exceptional feature of PS II is the water splitting reaction enabled by the Mn4Ca cluster. This results in the release of protons to the lumenal aqueous phase, release of electrons to a chain of acceptors,which provides metabolically available reduction equivalents, and release of dioxygen to the atmosphere. The high contentof lipids in the interior of photosystem II will be correlated with possible diffusion pathways of the dioxygen and the turnoverof the D1 protein, necessary to counteract the photodamage occurring within photosystem II. More structural details of integrallipids derived from higher resolution data from these remarkable membrane protein complexes in combination with data frommutant and/or spectroscopic studies will lead to extended functional insights in the future.<br/

    Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms: JSH-MPN-R18 subanalysis

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    Citation: Keiki Nagaharu, Eiko Ohya, Yoko Edahiro, Yoshinori Hashimoto, Tomoki Ito, Akihiko Gotoh, Mika Nakamae, Fumihiko Kimura, Michiaki Koike, Keita Kirito, Hideho Wada, Kensuke Usuki, Takayuki Tanaka, Takehiko Mori, Satoshi Wakita, Toshiki I. Saito, Akiko M. Saito, Kazuya Shimoda, Toshiro Kurokawa, Akihiro Tomita, Hitoshi Kiyoi, Koichi Akashi, Itaru Matsumura, Katsuto Takenaka, Norio Komatsu, Kohshi Ohishi, Isao Tawara, Yuka Sugimoto, Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms: JSH-MPN-R18 subanalysis, Annals of Hematology, 103(9), 3535-3541, 2024-07-22, https://doi.org/10.1007/s00277-024-05898-

    Investigation of the author(s) and year of publication of "Kozangaku" edited by the Imperial Japanese Army Academy (Study of the History of Mathematics 2021)

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    As for the text book “Kōzangaku” edited by the Imperial Japanese Army Academy, it is well known that there are no evidence of who is the author and when it was published. In this paper we propose that a new candidate of the author must be Masahide Kawatani, Army Artillery Lieutenant, and the year of publication is possibly 1887 which is one year earlier than its common view

    Ultra-microearthquake Activity in the Hida Region, Central Japan

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    上宝観測所では観測網の充実によって,多点のデータの収録解析が可能になったので,2001年10月以降,M0.5以下の極微小地震の震源を多数決定してきた。このことによって,跡津川断層や飛騨山脈での地震活動の様子がこれまでより短期間で明らかにできるようになってきた。M0.5以下の地震によって,飛騨山脈ではこれまでわからなかった多数の群発地震が見いだされるようになった。しかし,それ以外の地域では,空間分布は,深さ分布も含めてこれまで長期間に得られたものとほぼ同じであることがわかった。一方,時間変化については,検知率の問題はあるが,御岳付近の地震の減少と同時に焼岳以北の地震の増加が見られるなど,飛騨山脈で指摘されてきた地震発生の移動が検出された。また,M1.5程度の地震の発震機構を求めることが可能になり,跡津川断層付近の詳細な応力の地域的変化が得られた。Seismological network in the Hida region has been improved by use of the Hi-net and temporary station. We have beendetermined many hypocenters of ultra-microearthquakes with M less than 0.5 since Oct., 2001 at the Kamitakara Observatory, Kyoto University. We found many small earthquake swarms in the Hida Mountains from the results. In other areas thehypocenter distributions of the ultra-microearthquakes are nearly the same as those obtained for micro and small events fromthe long-time observations. However , space-time diagram of ultra-microearthquakes in the Hida mountains, shows asimultaneous increase of seismicity at the volcano Ontake and decrease in the north of the volcano Yakedake. This indicatesmigration of seismicity , similar to the phenomena sometimes occur for micro and small events in the Hida mountain range.Furthermore, we can determine focal mechanisms of micro and small earthquakes down to M1.5, which give detaileddistributions of earthquake generating stress near the Atotsugawa fault system.上宝観測所では観測網の充実によって,多点のデータの収録解析が可能になったので,2001年10月以降,M0.5以下の極微小地震の震源を多数決定してきた。このことによって,跡津川断層や飛騨山脈での地震活動の様子がこれまでより短期間で明らかにできるようになってきた。M0.5以下の地震によって,飛騨山脈ではこれまでわからなかった多数の群発地震が見いだされるようになった。しかし,それ以外の地域では,空間分布は,深さ分布も含めてこれまで長期間に得られたものとほぼ同じであることがわかった。一方,時間変化については,検知率の問題はあるが,御岳付近の地震の減少と同時に焼岳以北の地震の増加が見られるなど,飛騨山脈で指摘されてきた地震発生の移動が検出された。また,M1.5程度の地震の発震機構を求めることが可能になり,跡津川断層付近の詳細な応力の地域的変化が得られた。Seismological network in the Hida region has been improved by use of the Hi-net and temporary station. We have beendetermined many hypocenters of ultra-microearthquakes with M less than 0.5 since Oct., 2001 at the Kamitakara Observatory,Kyoto University. We found many small earthquake swarms in the Hida Mountains from the results. In other areas thehypocenter distributions of the ultra-microearthquakes are nearly the same as those obtained for micro and small events fromthe long-time observations. However , space-time diagram of ultra-microearthquakes in the Hida mountains, shows asimultaneous increase of seismicity at the volcano Ontake and decrease in the north of the volcano Yakedake. This indicatesmigration of seismicity , similar to the phenomena sometimes occur for micro and small events in the Hida mountain range.Furthermore, we can determine focal mechanisms of micro and small earthquakes down to M1.5, which give detaileddistributions of earthquake generating stress near the Atotsugawa fault system

    Observation of Earthquakes at the Kamitakara Observatory by a Dense Network in the Atotsugawa Fault Area-36 year observation and data analyses

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    上宝観測所によって始められた跡津川断層沿いの微小地震観測の結果,跡津川断層に沿う明瞭な地震の線状配列が明らかとなった。その後観測点の増設及びデータ収録システムの変更によって,震源精度が格段に向上して,震央分布では活動の不均質性が明らかになる一方,深さ分布では中央部から両端にかけて浅くなる傾向が明瞭となった。また,地震活動の時間的推移を見た場合,ほぼ定常的な活動の状態を示しているが,唯一の群発地震活動が1986年12月21日に中央部の宮川地区にて発生している。Observations of earthquakes in the Atotsugawa fault area have been carried out since 1969. Characteristics of spatial seismicity along the fault area are reported on the basis of the long term records. Focal depths are deepest in the middle and shallower in both ends of the fault. As for the temporal variations, activities are random with rare swarm activities, except for one in 1986 consisted of 431 events for a month with the maximum earthquake of M4.3.上宝観測所によって始められた跡津川断層沿いの微小地震観測の結果,跡津川断層に沿う明瞭な地震の線状配列が明らかとなった。その後観測点の増設及びデータ収録システムの変更によって,震源精度が格段に向上して,震央分布では活動の不均質性が明らかになる一方,深さ分布では中央部から両端にかけて浅くなる傾向が明瞭となった。また,地震活動の時間的推移を見た場合,ほぼ定常的な活動の状態を示しているが,唯一の群発地震活動が1986年12月21日に中央部の宮川地区にて発生している。Observations of earthquakes in the Atotsugawa fault area have been carried out since 1969. Characteristics of spatial seismicity along the fault area are reported on the basis of the long term records. Focal depths are deepest in the middle and shallower in both ends of the fault. As for the temporal variations, activities are random with rare swarm activities, except for one in 1986 consisted of 431 events for a month with the maximum earthquake of M4.3

    Seismic Activity near Hakusan Volcano, in Northeast Chubu District, Japan

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    白山火山の東山麓に衛星通信による地震観測点を設置した。この結果,白山火山の直下においてこれまで観測できなかったような微小地震が多数観測され,その活動は非常に浅いところに発生していることが明らかとなった。それらの活動は,時々群発化していることも明らかとなった。また,メカニズム解も求められ,この付近でこれまで求められている解と同じように,東西主圧力の横ずれ型であった。A new seismological observation station was installed in the eastern flank of Hakusan Volcano, in thenortheastern Chubu District in July, 2003. At the station, many microearthquakes were observed just beneath thevolcano and the focal depths are very shallow to be less than 3km. The seismic activities often occur in swarms.A relatively large shock with M3.3 occurred on October, 2003 for the first time after six years beneath thevolcano. The focal mechanism of the event is a strike-slip type with an E-W pressure axis as same as othershocks in the area.白山火山の東山麓に衛星通信による地震観測点を設置した。この結果,白山火山の直下においてこれまで観測できなかったような微小地震が多数観測され,その活動は非常に浅いところに発生していることが明らかとなった。それらの活動は,時々群発化していることも明らかとなった。また,メカニズム解も求められ,この付近でこれまで求められている解と同じように,東西主圧力の横ずれ型であった。A new seismological observation station was installed in the eastern flank of Hakusan Volcano, in thenortheastern Chubu District in July, 2003. At the station, many microearthquakes were observed just beneath thevolcano and the focal depths are very shallow to be less than 3km. The seismic activities often occur in swarms.A relatively large shock with M3.3 occurred on October, 2003 for the first time after six years beneath thevolcano. The focal mechanism of the event is a strike-slip type with an E-W pressure axis as same as othershocks in the area
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