410 research outputs found
[Archives de la parole]. , Deux poésies galloises (Ceiriog, Eifion Wynn). Trois poésies galloises (Robert ab Gwibym, J.M. Jones, Williams Parry) / Jean Poirot, éd. ; M. Ambrose Bebb, voix
No full textGalloisEnregistrement : (France) Paris, Université de Paris, La Sorbonne, 19-04-1921Comprend : Nant y Mynydd / John Ceiriog Hughes - Men / Eifion Wyn - Llwybr y bedd / Robert ap Gwilym Ddu - Hedd wyn / J. Morris Jones - Cymru fydd / Robert Williams Parr
Surveillance of adenoviruses and noroviruses in European recreational waters
No full textExposure to human pathogenic viruses in recreational waters has been shown to cause disease outbreaks. In the context of Article 14 of the revised European Bathing Waters Directive 2006/7/EC (rBWD, CEU, 2006) a Europe-wide surveillance study was carried out to determine the frequency of occurrence of two human enteric viruses in recreational waters. Adenoviruses were selected based on their near-universal shedding and environmental survival, and noroviruses (NoV) selected as being the most prevalent gastroenteritis agent worldwide. Concentration of marine and freshwater samples was done by adsorption/elution followed by molecular detection by (RT)-PCR. Out of 1410 samples, 553 (39.2%) were positive for one or more of the target viruses. Adenoviruses, detected in 36.4% of samples, were more prevalent than noroviruses (9.4%), with 3.5% GI and 6.2% GII, some samples being positive for both GI and GII. Of 513 human adenovirus-positive samples, 63 (12.3%) were also norovirus-positive, whereas 69 (7.7%) norovirus-positive samples were adenovirus-negative. More freshwater samples than marine water samples were virus-positive. Out of a small selection of samples tested for adenovirus infectivity, approximately one-quarter were positive. Sixty percent of 132 nested-PCR adenovirus-positive samples analysed by quantitative PCR gave a mean value of over 3000 genome copies per L of water. The simultaneous detection of infectious adenovirus and of adenovirus and NoV by (RT)PCR suggests that the presence of infectious viruses in recreational waters may constitute a public health risk upon exposure. These studies support the case for considering adenoviruses as an indicator of bathing water quality
Limiting Conditions of Muckenhoupt and Reverse Hölder Classes on Metric Measure Spaces
No full textFunding Information: Open Access funding provided by Aalto University. The author was supported by the Vilho, Yrjö and Kalle Väisälä Foundation of the Finnish Academy of Science and Letters. Publisher Copyright: © 2023, The Author(s).The natural maximal and minimal functions commute pointwise with the logarithm on A∞. We use this observation to characterize the spaces A1 and RH∞ on metric measure spaces with a doubling measure. As the limiting cases of Muckenhoupt Ap and reverse Hölder classes, respectively, their behavior is remarkably symmetric. On general metric measure spaces, an additional geometric assumption is needed in order to pass between Ap and reverse Hölder descriptions. Finally, we apply the characterization to give simple proofs of several known properties of A1 and RH∞, including a refined Jones factorization theorem. In addition, we show a boundedness result for the natural maximal function.Peer reviewe
Temperature dependence of the muon and proton hyperfine constants of an \alpha‐muonium‐substituted methyl radical
No full textMuon hyperfine constants A_μ have been measured by transverse field μSR for (CH3)3Si\mbox\.CHMu in hexane from 167 K to 332 K. In addition, avoided level‐crossing resonance was used to determine \alpha‐proton coupling constants Ap over a similar range of temperatures. The two hyperfine constants can be described by a common temperature dependence, d|Ai|/ dT=1.4\times 10-3 MHz\,K-1, where Ai represents Ap or the reduced muon constant A^\prime_μ=0.3141A_μ. There is a small isotope effect (A^\prime_μ is 2.2 % larger than Ap) consistent with zero‐point motion in the anharmonic C–H bond stretch. The common temperature dependence is tentatively attributed to a coupled deviation of the C–H and C–Mu bonds out of the nodal plane of the p orbital containing the unpaired electron.Peer reviewedFinal article publishedMuon Spin RotationNodal PlaneEthylsilaneBond StretchDiamagnetic Signa
Environmental toxicity, redox signaling and lung inflammation:the role of glutathione
No full textGlutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress. GSH metabolism is tightly regulated and has been implicated in redox signaling and also in protection against environmental oxidant-mediated injury. Changes in the ratio of the reduced and disulfide form (GSH/GSSG) can affect signaling pathways that participate in a broad array of physiological responses from cell proliferation, autophagy and apoptosis to gene expression that involve H(2)O(2) as a second messenger. Oxidative stress due to oxidant/antioxidant imbalance and also due to environmental oxidants is an important component during inflammation and respiratory diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and asthma. It is known to activate multiple stress kinase pathways and redox-sensitive transcription factors such as Nrf2, NF-kappaB and AP-1, which differentially regulate the genes for pro-inflammatory cytokines as well as the protective antioxidant genes. Understanding the regulatory mechanisms for the induction of antioxidants, such as GSH, versus pro-inflammatory mediators at sites of oxidant-directed injuries may allow for the development of novel therapies which will allow pharmacological manipulation of GSH synthesis during inflammation and oxidative injury. This article features the current knowledge about the role of GSH in redox signaling, GSH biosynthesis and particularly the regulation of transcription factor Nrf2 by GSH and downstream signaling during oxidative stress and inflammation in various pulmonary diseases. We also discussed the current therapeutic clinical trials using GSH and other thiol compounds, such as N-acetyl-l-cysteine, fudosteine, carbocysteine, erdosteine in environment-induced airways disease
Are you sitting comfortably? The political economy of the body
No full textThe aim of this paper is to examine the relationship between the mass production of furniture in modern industrial societies and lower back pain (LBP). The latter has proven to be a major cost to health services and private industry throughout the industrialised world and now represents a global health issue as recent WHO reports on obesity and LBP reveal. Thus far there have been few co-ordinated attempts to deal with the causes of the problem through public policy. Drawing upon a range of sources in anthropology, health studies, politics and economics, the paper argues that this a modern social problem rooted in the contingent conjuncture of natural and social causal mechanisms. The key question it raises is: what are the appropriate mechanisms for addressing this problem? This paper develops an analysis rooted in libertarian social theory and argues that both the state and the capitalist market are flawed mechanisms for resolving this problem. There remains a fundamental dilemma for libertarians, however. Whilst the state and the market may well be flawed mechanisms, they are the dominant ones shaping global political economy. To what extent can libertarians work within these structures and remain committed to libertarian goals
Welshing on postcolonialism : complicity and resistance in the construction of Welsh identities
No full textThe thesis places Wales within a postcolonial framework, and uses postcolonial theory to analyse the emergence of Welsh identities. Positioning ‘Wales’ and the ‘Welsh’ as subjects of study in relation to the British Empire suggests how discursive processes of power in Wales take place parallel to those in other areas of the Empire. In analysing these processes, the thesis illustrates the different effects of power in different local contexts. Welsh identities are shown as emerging and being produced by these discursive processes, and are found to be often resistant and complicit with dominant discourses in the same movement. In the central chapters of the thesis, the emergence of Welsh identities is analysed with reference to particular discourses and events: education, ritual, literary criticism and popular culture. These are, in Chapter 1, the Blue Books controversy; in Chapter 2, the investiture of the Prince of Wales in 1911 and again in 1969; and, finally, in Chapter 3,the construction of different theories of literary criticism and the role of play and authenticity in Welsh popular culture. Using the work of Michel Foucault, the thesis rejects the notion of an original and essential Welsh identity and takes power to be fluid and productive of subjects. Various articulations of Welsh identity appear as dynamic, hybrid and linked to particular discourses, allowing us to understand the emergence of such identities without reference to a pre-given Welsh identity.EThOS - Electronic Theses Online ServiceAPRSGBUnited Kingdo
A randomised controlled clinical trial of narrowband UVB phototherapy for clinically isolated syndrome: the PhoCIS Study
No full textBackground: The natural history of multiple sclerosis (MS) typically presents with the clinically isolated syndrome (CIS), an episode of neurological symptoms caused by central nervous system inflammation or demyelination that does not fulfil the diagnostic criteria for MS. Objective: As preclinical studies have suggested that exposure to ultraviolet radiation (UVR) could regulate the development of MS, the Phototherapy for CIS (PhoCIS trial) was established to examine the effects of narrowband UVB phototherapy on patients with CIS, and their conversion to MS. Methods: Of the 20 participants, half received 24 sessions of narrowband UVB exposure over eight weeks; participants in both arms were followed for 12 months. All participants were supplemented to 25-hydroxyvitamin D3 levels of >80 nmol/l. Results: By 12 months, 100% of those in the no phototherapy arm and 70% in the phototherapy arm had converted to MS, although this difference was not statistically significant. Conclusion: This study provides a basis for further studies to determine if there are any benefits of the therapeutic effects of narrowband UVB radiation on MS progression.The author(s) disclosed receipt of the following financial
support for the research, authorship, and/or publication of
this article: This work was supported by the National
Health and Medical Research Council of Australia (ID
1067209). Drs AP Jones, S Trend and MJ Fabis-Pedrini
were supported by MS Western Australia, and Prof RM
Lucas by a National Health and Medical Research Council
of Australia Senior Research Fellowship
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