1,158 research outputs found
Emerging technologies in solid drug delivery: An interview with Nadia Passerini
No full textNadia Passerini is interviewed by Hannah Makin, Commission Editor. Nadia Passerini is Associate Professor of Pharmaceutical Technology at the University of Bologna (Bologna, Italy). She obtained the degree in Pharmaceutical Chemistry and Technology at the University of Bologna in 1992 and the PhD in Pharmaceutical Science in 1997. Her research focuses on the study of drug delivery systems, developing new technologies and new apparatus for the production of solid dosage forms (microparticles, granules and tablets), which can optimize the bioavailability of drugs according to the specific needs of the therapy. Furthermore, she is interested in the solid-state characterization of the produced delivery systems in order to correlate their physicochemical properties to the in vitro release of the drugs. Currently, her research focuses in particular on the production and characterization of microparticles produced by the spray congealing technology. She is author of over 50 international peer-reviewed publications and over 50 contributions (poster and oral presentations) to national and international conferences
Correction to: CD38 as theranostic target in oncology (Journal of Translational Medicine, (2024), 22, 1, (998), 10.1186/s12967-024-05768-6)
No full textpeer reviewedFollowing publication of the original article [1], we have been notified that first and last names of the authors were switched and published incorrectly. They are now as follows: Bocuzzi Valentina1,6, Bridoux Jessica2, Pirotte Michelle3, Withofs Nadia4, Hustinx Roland5, D’Huyvetter Matthias2, Caers Jo3* and Marcion Guillaume1,6 They should be as follows: Valentina Bocuzzi1,6, Jessica Bridoux2, Michelle Pirotte3, Nadia Withofs4, Roland Hustinx5, Matthias D’Huyvetter2, Jo Caers3* and Guillaume Marcion1,6 The original article was updated
Selected Songs of Nadia Boulanger: Formal Analysis and Adaptation for Brass Chamber Music
No full textWorth can be a difficult thing to understand and define, even under the best of circumstances. Nadia Boulanger is known to have told her teacher, Gabriel Fauré, that “if there is one thing of which I am certain, it is that my music is worthless.” As a teacher, Boulanger empowered her students to listen for the internal logic present in the pieces of art that she considered valuable. This document will apply Nadia Boulanger’s teachings to her compositions to demonstrate that her music does have worth. To that end, these analyses will compile data to discern the internal logic in her pieces.
As a performer, Nadia Boulanger coupled her analytical beliefs to her performance practice; her concerts were shaped by and carefully crafted to present her analyses. Her formal classes included an informal ticket to hear her commentaries in action. Therefore, in addition to analytical validation, the author intends to demonstrate the value of Nadia Boulanger’s music through the arrangement and performance of her compositions as brass chamber music. as brass chamber music
Evaluation of [68Ga]Ga-PSMA-11 PET/CT in the early therapeutic assessment of metastatic castration-resistant prostate cancer patients treated by first-line novel hormonal agents
No full textMonitoring treatment response in metastatic castration-resistant prostate cancer (mCRPC) remains a major challenge. Conventional strategies, based on PSA levels and standard imaging, often provide delayed or ambiguous information and fail to capture tumor heterogeneity, leading to late identification of non-responders and potentially worse outcomes. This thesis investigated [⁶⁸Ga]Ga-PSMA-11 PET/CT as a dynamic biomarker for early therapy response assessment in mCRPC patients initiating androgen receptor pathway inhibitors (ARPIs), with the aim of determining whether early imaging changes could predict long-term clinical outcomes.
Across three studies, we explored the feasibility, prognostic value, and biological interpretation of early sequential [⁶⁸Ga]Ga-PSMA-11 PET/CT. The first study showed that global tumor response at 4 weeks was strongly associated with the 12-week response, highlighting the potential of early imaging to detect early treatment resistance, while cautioning against misinterpretation due to a possible flare phenomenon. The second study showed that while this flare was relatively common, affecting about one in four patients, it was generally of low magnitude. The third study demonstrated that interlesional heterogeneity, with progression in only a subset of lesions despite global stability or favorable response, was associated with early treatment failure and poor survival, underscoring the prognostic and potentially predictive value of lesion-level assessment using [⁶⁸Ga]Ga-PSMA-11 PET/CT.
Overall, these findings support the clinical relevance of early imaging and interlesional heterogeneity analysis, warranting further investigation to refine the prediction of treatment efficacy and failure in mCRPC. This approach could identify high-risk patients overlooked by standard criteria, enabling earlier treatment adaptation and potentially improving outcomes. This work establishes the foundation for a more dynamic, personalized, and biologically informed model to mCRPC management
Crazy
No full textCrazy was created and performed as a collaboration by Nadia Alam, the author, and Linda Clarke. Passages in bold type are quotes from Wild Roses, a novel followed by a Love Letter, by Jacques Ferron
Crazy
No full textCrazy was created and performed as a collaboration by Nadia Alam, the author, and Linda Clarke. Passages in bold type are quotes from "Wild Roses, a novel followed by a Love Letter", by Jacques Ferron
Navigating dating and romantic relationships as an adult with Tourette Syndrome: an exploratory study
No full textTourette Syndrome (TS) is a neurological disorder defined by recurrent and intrusive involuntary tics that begin in childhood. Individuals with TS often face significant psycho-social challenges, given the public nature of their tics and the fact that their symptoms are often misunderstood by others. This study explores how adults with TS navigate dating and romantic relationships, including the challenges they face and the strengths they have developed in this process. Five adult women with TS were interviewed using a semi-structured interview about their psycho-social experiences of living with TS and how the disorder has affected their dating experiences. The interviews were qualitatively analyzed as individual case studies and also compared and contrasted on the basis of five major research questions: 1) How do adults with TS navigate dating and romantic relationships? 2) What challenges and limitations do adults with TS face in dating and pursuing romantic relationships? 3) How do adults with TS go about explaining their symptoms to romantic partners? 4) How do the socio-emotional experiences of adults with TS with family and peers influence their dating experiences? 5) What factors are helpful for adults with TS in navigating dating and romantic relationships? Findings from the study indicate several themes among the subjects’ experiences: Choosing whether, why, when, how and what to disclose to partners; challenges of explaining tics and TS to others; reasons for concealing tics; impact of making disclosures to romantic partners; family and peers’ responses as a model for how romantic partners may respond; family and peers’ responses as a motivation for getting different responses from romantic partners; and considering genetics and children. Implications for individuals with TS and their parents are discussed, and recommendations for mental health professionals working with such individuals are made.Psy. D.Includes bibliographical referencesby Nadia Lem
Aspek Religi dalam Novel Surga yang Tak Dirindukan Karya Asma Nadia: Kajian Semiotik dan Implementasinya dalam Pembelajaran Sastra di Sma
No full textThe purpose of this study was to describe: (1) siocultural background author of the novel Surga yang tak Dirindukan by Asma Nadia; (2) entanglement between elements of structuralism in novel Surga yang tak Dirindukan by Asma Nadia; (3) religious values using semiotic study of iterature contained in the novel Surga yang tak Dirindukan by Asma Nadia; (4) to describe the implementation of the research results from novel Surga yang tak Dirindukan asmaterials criterion teach in high school. The research method using qualitative descriptive. The source of data in this research is the novel Surga yang tak Dirindukan by Asma Nadia. The forms of data in this study a phrases, sentences, or paragraph that contains religious values. The technique of collecting data used the preferences techniques. Data were analyze technique using the method of reading semiotic models that include reading heuristik and hermeunetik. The results of indicate that: (1) sociocultural background of the author of the novel Surga yang tak Dirindukan by Asma Nadia; (2) the elements of structuralism and the fact that the theme of the story has a very strong entanglement and coheren; (3) religious values using semiotic studies contained in the novel Surga yang tak Dirindukan by Asma Nadia; (4) implementation of research results from novel Surga yang tak Dirindukan materials criterion teach in high school.
Keywords: religious values, novel Surga yang tak Dirindukan, semiotic, learning literature of high school
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