6 research outputs found
Parallel session 1 : Teaching and learning innovations
No full textPresented Titles: Promoting Self-compassion and Self-reflection Through the Use of Action Method as Interactive Agent in Counsellor Training [Authors: Yee-lap To; Pui-chi Tse; Wai Fu] Meaning Creation: Writing in English but Thinking in First Language [Author: Namal Wickramasekera] Negative Emotions Induced by Feedback and Emotion Regulation of Hong Kong University Students: Exploring the Role of Feedback Orientation [Authors: Lan Yang; Yiqi Wu
Explore the effectiveness of online teaching and learning of morphological awareness for linguistically underprivileged English medium university students (in Sri Lanka)
No full textIn the proposed study, researcher will investigate the online teaching and learning of morphological awareness with the main purposes of assessing the improvement of the level of vocabulary and grammar of students studying in the medium of English. Specifically, this study aims to compare the success rate of students learning English completely online and those following blended learning. Due to COVID-19 pandemic, education has changed intensely, with the distinctive rise of online learning, whereby teaching and learning are undertaken remotely and on digital platforms. The advantages and disadvantages of online teaching and learning have become apparent in different phases of our modern life particularly in higher education without face-to-face interaction between teachers and students in classrooms. Though there are advantages and disadvantages of online teaching and learning, with this present situation in the country and the world, researcher determined to investigate the effectiveness of only online and blended teaching and learning of morphological awareness for low English proficiency learners studying vocabulary and grammar in Sri Lankan universities. The Community of Inquiry (CoI) framework highlights social presence, teaching presence, and cognitive presence as essential elements to facilitate successful educational experiences in online distance learning environments. Garrison et al. (1999) proposed a CoI model for educational developers to assist in the organisation of online and blended educational experiences. Therefore, the researcher will use the CoI model developed by Garrison and Anderson (2003) and Vygotsky’s sociocultural theory as a base for the proposed research
The design of a sealed artificial hip replacement
No full textTotal hip replacement is a very successful orthopaedic procedure for patients with disabling joint diseases. However, it is common for these implants to last for only l0-15 years before revision surgery is required. The major long term complication in total hip arthroplasty is aseptic loosening which has largely been attributed to wear of prostheses. Vy'ear particles emanating from any of the interfaces of the replacement system are known to interact with the tissues surrounding replacements causing an adverse tissue response and eventual loosening of the implant. Of particular concern is the amount of wear debris produced at the articulation of the femoral head and acetabular component. The aim of this thesis is to produce a new design of artificial hip prosthesis that addresses the problem of wear particles and subsequent loosening. Prior to designing a new replacement system an extensive historical review of hip replacement was undertaken. In addition the mechanisms, determinants and biological implications of wear have been examined. The anatomy and biomechanics of the hip joint were considered and current materials and their biocompatability assessed for possible use in this design. All of these subjects were analysed critically prior to design and development of a new system. A sealed modular hip replacement system has been designed and developed in this thesis. The joint is sealed with a polymer sleeve that attaches near the periphery of the acetabular insert and a flange on the modular femoral head. These components combine to form a sealed bearing which would be delivered sterile from manufacture, ready for implantation at the time The Design of a Sealed Artificial Hip Replacement of surgery. A sealed joint ensures that wear particles cannot escape to the surrounding tissues and also prevents debris from entering the articulation and causing third body wear The sealing membrane traps all wear particles produced at the articulating surface within the sealed joint and it is proposed that a wear particle collection chamber is employed to collect them. The use of a ceramic or other porous material in which particles can lodge will reduce second body wear of the joint surfaces. As some of the designs developed in this thesis are novel concepts with commercial potential, a provisional patent has been filed. A preliminary marketing exercise has also been undertaken with a major implant manufacturer The author believes that this novel design of hip replacement system has the potential to increase the survival of hip replacement systems by the elimination of a major long term failure mode of aseptic loosening caused by wear particlesThesis (M.Med.Sc.)-- University of Adelaide, Dept. of Orthopaedics and Trauma, 199
Hafez's Master's Perspective: The Fault of Creation's Pen
No full textThis article attempts to categorize the various interpretations of the famous verse: "Our Master said...” As the article argues, many of these interpretations reflect the interpreters' views based on their studies of Islamic mysticism and Hafez's poetry or those of other mystic poets. Interpreters have criticized the views of others from a rhetorical and poetic perspective. The purpose of this article is to locate a Quranic source that discusses the aspect of humor in the verse. According to the author, this evidence can be found in verse 88 of Surah Namal. Further to explain, if the master sees a mistake and asserts that there is none, he has covered up a mistake, and this is humorous. Another aspect of humor relates to the Arabic word "Sone'" (Creation), which is translated as "goodness" in Arabic dictionaries. Thus, the Master's work is about the pen of the "Good Creator", not the absolute pen. In this case, the master's concealment of the fault can be described as conscious, educative, and optimistic. Second, the research completes Jalal Dawani's statement: "The fate and destiny's pen does not make mistakes." In order to support this argument, we have used the denotative meanings of the terms "right" and "mistake", "fulfillment" and "unfulfillment", as well as the meaning of the fulfillment of Fate's pen equated with God's will
Beyond traditional therapies: clinical significance of complex molecular profiling in patients with advanced solid tumours—results from a Turkish multi-centre study
No full textObjective: The objective of this multi-centre, real-world study was to examine the potential influence of comprehensive molecular profiling on the development of treatment decisions or adjustments for patients with advanced solid malignancies. We then evaluated the impact of these informed choices on patient treatment outcomes. Methods: The study encompassed 234 adult patients (mean age: 52.7 ± 14.3 years, 54.7% women) who were diagnosed with solid tumours at 21 different medical centres in Turkey. Remarkably, 67.9% of the patients exhibited metastasis at the time of diagnosis. We utilized an OncoDNA (Gosselies, Belgium) platform (OncoDEEP) integrating next-generation sequencing with additional tests to harvest complex molecular profiling data. The results were analyzed in relation with two specific outcomes: (i) the impact on therapeutic decisions, including formulation or modifications, and (ii) associated treatment response. Results: Out of the 228 patients with final molecular profiling results, 118 (50.4%) had their treatment modified, whilst the remaining 110 (47.0%) did not. The response rates were comparable, with 3.9 versus 3.4% for complete response, 13.6 versus 29.3% for partial response, 66.9 versus 51.7% for progressive disease and 15.5 versus 15.5% for stable disease for treatments informed and not informed by complex molecular profiling, respectively (P = 0.16). Conclusion: Our real-world findings highlight the significant impact of complex molecular profiling on the treatment decisions made by oncologists for a substantial portion of patients with advanced solid tumours. Regrettably, no significant advantage was detected in terms of treatment response or disease control rates. © The Author(s) 2024. Published by Oxford University Press. All rights reserved
Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma
No full text© The Author(s), under exclusive licence to Springer Nature Limited 2019In cancer, recurrent somatic single-nucleotide variants-which are rare in most paediatric cancers-are confined largely to protein-coding genes1-3. Here we report highly recurrent hotspot mutations (r.3A>G) of U1 spliceosomal small nuclear RNAs (snRNAs) in about 50% of Sonic hedgehog (SHH) medulloblastomas. These mutations were not present across other subgroups of medulloblastoma, and we identified these hotspot mutations in U1 snRNA in only <0.1% of 2,442 cancers, across 36 other tumour types. The mutations occur in 97% of adults (subtype SHHδ) and 25% of adolescents (subtype SHHα) with SHH medulloblastoma, but are largely absent from SHH medulloblastoma in infants. The U1 snRNA mutations occur in the 5' splice-site binding region, and snRNA-mutant tumours have significantly disrupted RNA splicing and an excess of 5' cryptic splicing events. Alternative splicing mediated by mutant U1 snRNA inactivates tumour-suppressor genes (PTCH1) and activates oncogenes (GLI2 and CCND2), and represents a target for therapy. These U1 snRNA mutations provide an example of highly recurrent and tissue-specific mutations of a non-protein-coding gene in cancer.info:eu-repo/semantics/publishedVersio
