1,721,015 research outputs found
In vivo modulation of N-myc expression by continuous perfusion with an antisense oligonucleotide.
No full textAntisense suppression of N-myc expression inhibits the transdifferentiation of neuroectoderm tumor cell lines.
No full textAntisense suppression of N-myc expression inhibits the transdifferentiation of a neuroectodermal cell line
No full textSingle copy N-myc expression is involved in the control of growth and morphology of a human neuroepithelioma cell line.
No full textEpisome generated antisense suppression of N myc expression blocks morphologic differentiation of a human neuroepithelioma cell line
No full textEPISOME-GENERATED N-MYC ANTISENSE RNA RESTRICTS THE DIFFERENTIATION POTENTIAL OF PRIMITIVE NEUROECTODERMAL CELL-LINES
No full textAntisense inhibition of oncogene expression.
No full textTo understand the role of individual genes in regulating biological processes, one must be able to interfere specifically with either their expression or function. While monoclonal antibodies have proven very useful in studying cell surface proteins, the specific inhibition of intracellular proteins in viable cells is a much more difficult problem. The goal of antisense technology is to develop small oligonucleotides, plasmids, or retroviral vectors which can be readily introduced into living cells in order to inhibit specific gene expression. In this review, we briefly describe the principles of antisense usage, including problems of cellular uptake and intracellular distribution, mechanism of antisense action, and the properties of various oligonucleotide derivatives. In addition we present several examples of the biological effects of antisense administration used to study the role of specific genes in the regulation of cell growth and differentiation
ANTISENSE INHIBITION OF SINGLE COPY N-MYC EXPRESSION RESULTS IN DECREASED CELL-GROWTH WITHOUT REDUCTION OF C-MYC PROTEIN IN A NEUROEPITHELIOMA CELL-LINE
No full textAntisense inhibition of N-myc reduces cell growth but does not affect c-myc expression in the neuroepithelioma cell line CHP100.
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