171 research outputs found
Growth inhibition induced by transforming growth factor-beta1 in human oral squamous cell carcinoma
No full textXiumei Wang, Wenjing Sun, Jing Bai, Linlin Ma, Yang Yu, Jingshu Geng, Jiping Qi, Zhongcheng Shi and Songbin F
GLI Pathogenesis-Related 1 Functions as a Tumor-Suppressor in Lung Cancer
No full textBackground: GLI pathogenesis-related 1 (GLIPR1) was originally identified in glioblastomas and its expression was also found to be down-regulated in prostate cancer. Functional studies revealed both growth suppression and proapoptotic activities for GLIPR1 in multiple cancer cell lines. GLIPR1s role in lung cancer has not been investigated. Protein arginine methyltransferase 5 (PRMT5) is a protein arginine methyltransferase and forms a stoichiometric complex with the WD repeat domain 77 (WDR77) protein. Both PRMT5 and WDR77 are essential for growth of lung epithelial and cancer cells. But additional gene products that interact genetically or biochemichally with PRMT5 and WDR77 in the control of lung cancer cell growth are not characterized. Methods: DNA microarray and immunostaining were used to detect GLIPR1 expression during lung development and lung tumorigenesis. GLIPR1 expression was also analyzed in the TCGA lung cancer cohort. The consequence of GLIPR1 on growth of lung cancer cells in the tissue culture and lung tumor xenografts in the nude mice was observed. Results: We found that GLIPR1 expression is negatively associated with PRMT5/WDR77. GLIPR1 is absent in growing epithelial cells at the early stages of mouse lung development and highly expressed in the adult lung. Expression of GLIPR1 was down-regulated during lung tumorigenesis and its expression suppressed growth of lung cancer cells in the tissue culture and lung tumor xenografts in mice. GLIPR1 regulates lung cancer growth through the V-Erb-B avian erythroblastic leukemia viral oncogene homolog 3 (ErbB3) Conclusions: This study reveals a novel pathway that PRMT5/WDR77 regulates GLIPR1 expression to control lung cancer cell growth and GLIPR1 as a potential therapeutic agent for lung cance
BASIC PERSPECTIVES OF VLADIMIR NABOKOV’S METAPHYSICS
No full textVladimir Vladimirovich Nabokov is a distinctive representative of Russian literature in the 20th century. His works are studied by many famous artists in many countries. The conciseness and beauty of his language are unique characteristics of Nabokov’s creation. His works show great philosophical depth, high moral values, and aesthetic accomplishments. His erudition has also attracted the attention of the world. This paper mainly expounds his metaphysical ideas: Nabokov’s metaphysics is mainly expressed in his great understanding of the world and his ability to understand and his longing for something grand and incomparable. His philosophical, ethical and moral ideas have incorporated the views of various literary schools, formalism, and structuralism at home and abroad. In addition, this article analyzes the relationship between philosophy, ethics, linguistics, reality and non-reality, reality and lies through the study of many works of the author; it clearly defines the distinction between “game” and “acting”; explained a series of problems of the author’s creation techniques; summed up the themes such as “time and permanence”, “memory and memories” in Nabokov’s works. These are all reflected frequently in Nabokov’s works. It is precisely because of this that his works have also been studied as metaphysical works for the public
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Synthesis and structure of new transition metal containing bismuth oxides
No full textExploratory synthesis is the discovery of new compounds with interesting structures and properties. The subject of this thesis is exploratory synthesis of bismuth containing oxides. Bismuth containing oxides have many interesting properties, which are ionic conductivity, ferromagnetism, superconductivity, ferroelectricity, ferroelasticity and catalytic. These properties are closely related to their specific structure which is caused by the lone electron pair effect on Bi ³⁺, in other words, hybridization of the 6s and 6p states results in interesting stereochemistry. This can lead to some unusual and potentially useful properties. Several new compounds BiMn₂NO₆ (N = P, V, As) in the BiMn₂NO₆ family (M divalent cation, N = pentavalent cation) have been synthesized. The structures were refined by powder X-ray and neutron diffraction data. The X-ray diffraction patterns showed these three compounds have similar structures. Like other compounds in the BiMn₂NO₆ family, they contain (BiO₂)⁻ infinite chains, (AO₄)³⁻ tetrahedral and interspersed M²⁺ cations. Based on these same building blocks, they exhibit their own structure. BiMnPO₅ compound has been prepared and refined by powder neutron diffraction data. This material crystallizes in monoclinic symmetry. The structure can be described in terms of mixed double-chains of two edge-sharing Mn06 octahedral alternating with two edge-sharing BiO₆ octahedra. The mixed double-chains are connected to each other through the PO₄ tetrahedra. During the investigation of the BiMNO₅ family, BiMnVO₅ and BiMnAsO₅ have also been synthesized. Their structures were determined from X-ray single crystal data. Both of them crystallized in P1 space group. Bi is five fold coordinated instead of six-fold as for BiMnPO₅, since the sixth oxygen-bismuth distance is over 3.20Å. This point also shows some link of the comparable structures between these three new compounds. Pyrochlore type Bi-Ta(Nb)-Mn-O new compounds were also prepared, the structures have been determined from X-ray single crystal data. They crystallized in cubic symmetry
Core index of perfect matching polytope for a 2-connected cubic graph
No full textFor a 2-connected cubic graph , the perfect matching polytope of contains a special point . The core index of the polytope is the minimum number of vertices of whose convex hull contains . The Fulkerson’s conjecture asserts that every 2-connected cubic graph has six perfect matchings such that each edge appears in exactly two of them, namely, there are six vertices of such that is the convex combination of them, which implies that . It turns out that the latter assertion in turn implies the Fan-Raspaud conjecture: In every 2-connected cubic graph , there are three perfect matchings , , and such that . In this paper we prove the Fan-Raspaud conjecture for with certain dimensional conditions
Boundedness of solutions to a second-order periodic system with p-Laplacian and unbounded perturbation terms
No full textAbstract The second-order periodic system with p-Laplacian and unbounded time-dependent perturbation terms is investigated. Using the principle integral method, it is shown that under certain assumptions on the unbounded and periodic terms, all solutions to the equation possess boundedness
A note on pm-compact bipartite graphs
No full textA graph is called perfect matching compact (briefly, PM-compact), if its perfect matching graph is complete. Matching-covered PM-compact bipartite graphs have been characterized. In this paper, we show that any PM-compact bipartite graph G with δ (G) ≥ 2 has an ear decomposition such that each graph in the decomposition sequence is also PM-compact, which implies that G is matching-covere
Thermo-optical properties of uniaxial NaT(XO4)2 laser host crystals (where T = Y, La, Gd or Bi, and X = W or Mo)
No full textThermo-optic coefficients dn o/dT and dn e/dT were measured in tetragonal double tungstate and double molybdate crystals NaT(XO4)2 (where T = Y, La, Gd or Bi and X = W or Mo) by a laser beam deviation method in the spectral range 0.4-1.1 μm. Thermal expansion coefficients in the directions of a and c crystallographic axes were also measured. Analytical expressions for thermo-optic dispersion formulas were derived as series in 1/λ 2. All dn/dT values for NaT(XO 4)2 crystals were found to be negative. Their absolute values satisfy the relation |dn e/dT| > |dn o/dT| for crystals without Bi and |dn o/dT| > |dn e/dT| for crystals with Bi. A clear tendency for dn/dT values to decrease with the increase of the volumetric thermal expansion coefficient α vol of the crystal was observed. This is related with dominant contribution of volumetric thermal expansion effect to the temperature dependence of the refractive index. Thermal coefficients of the optical path W = dn/dT + (n - 1)α T governing thermal lensing effect were calculated for different light propagation directions and polarizations as well as crystal athermal directions. © 2013 Springer-Verlag Berlin Heidelberg.This work was supported by the Spanish Ministry of Economy and Competitiveness under project MAT2011-29255-C02-01.Peer Reviewe
Prediction of stem extension of lucerne (Medicago sativa L.) in early spring
No full textThe ability to predict the time of rapid stem extension in spring can be used to assist the development of lucerne grazing management plans. Therefore, the aim of this work was to validate the APSIM_Lucerne height function generated by Yang et al. (2021) for early spring. Two experiments in 2022 and 2023 used four winter defoliation dates (01/06, 03/07, 17/07, 01/08) to measure the time and rate of initial stem extension (height) in spring. The data were used to validate the APSIM_Lucerne height function which is based on thermal time accumulation targets modified by photoperiod. The current exponential decay curve in ASPIM showed a poor agreement (RMSE = 2.1) because it had limited data through the winter period. This
was modified using the 2022 and 2023 field data, which showed the start of stem extension occurred at a
photoperiod of 11.1 h. This was consistent with the original dataset. The change in photoperiod direction was accounted for calculating a weighted mean photoperiod from the start of the regrowth rotation (in a
decreasing photoperiod) up to the 11.1 h increasing photoperiod until the end of rotation. This improved
(RMSE = 1.49) the prediction of plant height and is recommended for implementation into the
APSIM_Lucerne framework. In the field, the start of maximum stem extension occurred at an 11.1 h in both
years, which suggests this is the critical photoperiod required before rapid stem extension occurs. However,
this remains to be validated in other environments
Figure 4
No full text<p>A) ALP activity normalized by DNA amount cultured on the different hydrogels for two weeks. RADA16∶RADA16 1% (w/v), ALKmx: ALK 1% (w/v)+RADA16-I, DGRmx∶DGR 1% (w/v)+RADA16, PRGmx∶PRG 1% (w/v)+RADA16 (all mixture ratio is 1∶1). ALK, DGR and PRG show the higher ALP activity compared to RADA16-I. *p<0.01 suggesting it is significant against the ALP activity in pure RADA16-I. B) Osteocalcin content secreted in culture medium after culturing on the different hydrogels for two weeks. RADA16∶RADA16 1% (w/v), ALKmx∶ALK 1%(w/v)+RADA16, DGRmx∶DGR 1%(w/v)+RADA16, PRGmx∶PRG 1% (w/v)+RADA16 (all mixture ratio is 1∶1). All modified peptides (ALK, DGR and PRG) show the higher osteocalcin contents compared to pure RADA16. PRG has a significantly higher concentration compared to the other scaffolds. *p<0.01 suggesting it is significant against Osteocalcin in RADA16 scaffold.</p
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