1,723,792 research outputs found
W. Lewis Civil War letter
No full textThis collection contains a letter written in November 1864 by W. Lewis, then stationed at DeValls, Bluff, Ark. The author is believed to be Walter Lewis of Company F of the 20th Iowa Infantry
John W. Lewis Civil War letter
No full textThis collection contains a letter written at Camden, Ark., by Captain John W. Lewis to Mrs. Cara Peyton
Mrs. Earl W. Lewis
No full textMrs. Earl W. Lewis, of 3717 Lenox, to be installed as president of the Clio Club at its spring luncheon that would be held on the 9th of May, 1950. She is shown sitting on a couch next to a dog by the name of Pudgie. Published in the evening edition, May 1, 1950.https://mavmatrix.uta.edu/specialcollections_startelegram1950s/3572/thumbnail.jp
"C. W. Lewis" in Old Town
No full textOx cart and driver in front of territorial style building with sign "C. W. Lewis" in Old Town (Albuquerque
Rev. Dr. W. Lewis, Sr.
No full text4 x 6 inch photograph. Rev. Dr. W. Lewis, Sr., member of the Board of Directors of the Philadelphia School District Parent's Union300 dpi compressed jpg is displayed. Epson Expression 1640 XL Scanner, Epson TWAIN Pro, Adobe Photoshop 7.0, Archival Master file is a TIFF
Zidovudine causes early increases in mitochondrial ribonucleic acid abundance and induces ultrastructural changes in cultured mouse muscle cells
No full textBACKGROUND: Zidovudine (azidothymidine, AZT) causes a toxic mitochondrial myopathy in AIDS patients with changes in mitochondrial (mt) DNA and mitochondrial structure. To determine early subcellular events in AZT myopathy in vitro we examined C2C12 myotubes treated with AZT (0.2, 2, 10 μg/ml) for up to 4 weeks. We identified AZT-induced effects on muscle intracellular compartments by determining the comparative abundance of selected myotube cytoplasmic and mtRNAs and mtDNA. EXPERIMENTAL DESIGN: RNA and DNA were extracted from cultured C2C12 myotubes, blotted and probed with cDNAs specific for the mitochondrial gene products cytochrome b and cytochrome c oxidase I, nuclear-encoded sarcomeric troponin C, and cytoplasmic glyceraldehyde-3-phosphate dehydrogenase. Transmission electron microscopy was performed on parallel samples. RESULTS: After 4 weeks of AZT, cytochrome b and cytochrome c oxidase I mtRNA abundance increased to 64% and to 31% above respective control levels. No change occurred in mtDNA abundance or nuclear encoded glyceraldehyde-3-phosphate dehydrogenase mRNA compared with the nuclear encoded sarcomeric troponin C control. Transmission electron microscopy showed focal disruption of mitochondrial cristae with intramyocytic lipid droplets after 14 days of AZT treatment. CONCLUSIONS: Increased mtRNA abundance in absence of changes in mtDNA abundance suggests that early AZT toxicity to mitochondria may relate to defects in mtDNA replication or mtRNA transcription
Portrait of Henry W. Lewis (Louis?), [s.d.]
No full textPhotographic portrait of Henry W. Lewis (Louis?), [s.d.]. Mr. Lewis is pictured from his head to his upper torso and his shoulders are turned to the left, although his head is facing straight ahead. He is wearing a dark jacket and vest, along with a tie and light shirt. He has rimless glasses on his face and curly light hair on his head
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