39,233 research outputs found
Butō-fu. Obraz w umyśle, obraz w ciele
No full textCharakterystyczna dla japońskiego butō technika – wcielanie obrazu – ma wiele wariantów. Techniki wykorzystywane w treningu butō są narzędziem służącym własnej przemianie i jej katalizatorem. Reakcje ideokinetyczne i ideodynamiczne mogą stanowić bazę fundamentalnej dla butō metody, której narzędziem są tzw. butō-fu, „notacje butō”. Praca z butō-fu jest spokrewniona nie tylko z zenistyczną metodą pracy z koanem, ale również z popularną w świecie zachodnim w XX wieku ideokinetyką, zreinterpretowaną i rozpropagowaną jako technika treningowa tancerzy w latach 90. przez Erica Franklina.Magdalena Zamorsk
Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial
No full textOral capecitabine (Xeloda<sup>®</sup>) is an effective drug with favourable safety in adjuvant and metastatic colorectal cancer. Oxaliplatin-based therapy is becoming standard for Dukes' C colon cancer in patients suitable for combination therapy, but is not yet approved by the UK National Institute for Health and Clinical Excellence (NICE) in the adjuvant setting. Adjuvant capecitabine is at least as effective as 5-fluorouracil/leucovorin (5-FU/LV), with significant superiority in relapse-free survival and a trend towards improved disease-free and overall survival. We assessed the cost-effectiveness of adjuvant capecitabine from payer (UK National Health Service (NHS)) and societal perspectives. We used clinical trial data and published sources to estimate incremental direct and societal costs and gains in quality-adjusted life months (QALMs). Acquisition costs were higher for capecitabine than 5-FU/LV, but higher 5-FU/LV administration costs resulted in 57% lower chemotherapy costs for capecitabine. Capecitabine vs 5-FU/LV-associated adverse events required fewer medications and hospitalisations (cost savings £3653). Societal costs, including patient travel/time costs, were reduced by >75% with capecitabine vs 5-FU/LV (cost savings £1318), with lifetime gain in QALMs of 9 months. Medical resource utilisation is significantly decreased with capecitabine vs 5-FU/LV, with cost savings to the NHS and society. Capecitabine is also projected to increase life expectancy vs 5-FU/LV. Cost savings and better outcomes make capecitabine a preferred adjuvant therapy for Dukes' C colon cancer. This pharmacoeconomic analysis strongly supports replacing 5-FU/LV with capecitabine in the adjuvant treatment of colon cancer in the UK
EpCAM Aptamer Activated 5-FU-Loaded PLGA Nanoparticles in CRC Treatment; In vitro and In vivo study
No full textIn this study, EpCAM aptamer-activated nanoparticles (Ap-NPs) were synthesized to enhance treatment efficiency in colorectal cancer (CRC). PLGA [poly (D, L-lactide-co-glycolide)] copolymer was fabricated by conjugation of COOH-PEG-NH2 to PLGA-COOH through an EDC/NHS-mediated chemistry. Afterward, 5‐fluorouracil-loaded (FU) nanoparticles were prepared using the water/oil/water double emulsion solvent evaporation method. The in vitro cytotoxicity of formulations was evaluated using the MTT assay in HCT-116, CT-26, and HEK-293 cell lines. For in vivo study, tumor-bearing BALB/c mice were established by subcutaneous injection of CT-26 cell line. The results indicated that fabricated AP-FU-NPs had 101 nm size with a spherical surface, relatively homogeneously and, satisfactory encapsulation efficiency (83.93%). In vitro experiments revealed that Ap-FU-NPs had a superior in vitro cytotoxicity than both FU-NPs and free 5-FU in CT-26 and HCT-116 cells but, were significantly low toxic against HEK-293 cells relative to free 5-FU. Furthermore, in vivo results showed no significant hemolytic effect, hepatic and renal injury, or weight loss. After treatment of various animal groups with formulations, notable tumor growth delay was observed followed the order: Ap-FU-NPs The overall strategy of this study is summarized in Graphical Abstract. The present study was carried out in the three steps summarized: 1) synthesis and characterization. At first, PEG was conjugated to PLGA polymers by EDC/NHS chemistry method, then the resulting polymers were used to prepare PLGA-PEG NPs via the W/O/W technique. Finally, EpCAM Aptamers were attached to fabricated NPs. 2) In the second step cytotoxicity of formulated NPs was evaluated in vitro experiments in HEK-293, CT-26, and HCT-116 cell lines. 3) In the third step in vitro results further was investigated in CT-26 tumor-bearing BALB/c mice. “Created with BioRender.com.”</p
Electric field determination of polymeric dc power cable in the presence of space charge
No full textSpace charge in polymeric power cables has been previously measured by the pulsed electroacoustic (PEA) technique and its influence on electric field distribution has been estimated assuming that the conductivity is independent of electric field. In this paper we proposed a method of determining electric field distribution considering the influence of the effect of electric field on the conductivity. The cable insulation is divided into thin layers with different conductivities and space charge present in the each layer is viewed as the consequence caused by difference in conductivity. Based on the hopping conduction mechanisms, it is possible to compute electric field distribution across the cable insulation. Compared with the electric field distribution without considering change in conductivity, the new proposed method shows reduction at the maximum electric field. However, the position of the maximum electric field shifts depending on space charge distribution
Fu Describing About the Author Himself: A Focus on Ban Gu "You tong fu"
No full textFrom Later Han dynasty onwards, the number of fu describing about the author himself has increased. There are several possible reasons for this, but the most important reason is probably that there was no other genre through which one could express oneself except for fu in this period. For instance, the fiveword poetry was still in the middle way of establishing its own style at that moment. Moreover, in Former Han, there were few opportunities for authors to talk about themselves in detail in fu, because the main readers were emperors and kings of countries. In Later Han, the readers had become more diverse. That is probably the reason why more fu began to mention about the authors themselves in this period. Ban Gu (32-92), who is a representative scholar of Later Han and also a man of letters, expressed his aim by writing "You tong fu". Its main content is that though one's encounter with a disaster or felicity is not always derived from our behavior, we have to have a strong will and take action to overcome disasters. This idea is supported by Ban Gu's experiences of not attaining his aim. Such experiences are common in Chinese authors. One of the earliest examples is Chu Ci. Also, Chu Ci is the one of the origins of fu. It is surprising that authors expressed things about themselves mostly in fu describing journeys. It may be easier to understand this tendency if we think they substituted the heaven wander in Chu Ci with a ground journey. Chu Ci was a model for authors to express their aim which could not come true, even if the journey on the ground and the wander in heaven are different
Percepcja przestrzeni miejskiej – uczestnicy procesu i ich rola w przestrzeni
No full textW artykule przedstawiono najważniejsze zagadnienia związane z postrzeganiem i waloryzacją przestrzeni miejskiej przez różne grupy użytkowników. W pierwszej części ukazano teoretyczne ujęcie kwestii percepcji przestrzeni miasta w postaci koncepcji Kevina Lyncha oraz Yi Fu Tuana. Następnie wyróżniono główne grupy uczestników procesu percepcji oraz opisano ich rolę w przestrzeni. W ostatniej części zaproponowano i opisano teoretyczne implikacje łańcucha przyczynowo-skutkowego procesu waloryzacji przestrzeni w postaci oceny i przemian przestrzeni. Głównym celem artykułu jest wskazanie teoretycznych podstaw procesów postrzegania przestrzeni miast, w tym prezentacja modelu „nowej percepcji” w sytuacji zmian w przestrzeni miejskiej
Painting in the Poetics of Du Fu 杜甫
No full textRóżne elementy analogii poezja-malarstwo zastosowane do poezji Du Fu odzwierciedlają krytyczne zróżnicowanie, a nie wspólnotę myśli. Żadna z nich nie ma odniesienia do oryginalnego kontekstu, w którym pojęcie „w poezji jest malarstwo” ma znaczenie.W swoich wierszach Du Fu testował granice przedstawiania w poezji i poszerzał horyzont znaczeniowy poezji w pogoni za tym, co określał jako najwyższe znaczenia piękna wykraczającego poza słowa i obrazy, tworząc krytyczną syntezę swojej poetyki.The various elements of poetry-painting analogy applied to Du Fu’s poetry reflect critical differentiation rather than a community of thought. None of them have reference to the original context in which the notion of “in poetry is painting” has meaning.In his poetry, Du Fu tested boundaries of poetry and widened the horizon of poetry in pursuit of what he termed as the highest meanings of beauty beyond words and images, creating a critical synthesis of poetry
Pareuchiloglanis sichuanensis Ding, Fu & Ye 1991
No full textPareuchiloglanis sichuanensis Ding, Fu & Ye 1991 Pareuchiloglanis sichuanensis Ding, Fu & Ye 1991: 371 (English p. 374), fig. 2. Type locality: Baoxing, Sichuan, China. Holotype: Sichuan Agric. Univ. 6-1481. Paratypes: KIZ 840561 (1), Sichuan Agric. Univ. 6-1488-91 (4), KIZ 850150 (1), SPNRI 40562-72 (11). Distribution: Yangtze drainage, China (Ding et al., 1991; Fu et. al., 2003).Published as part of Alfred W. Thomson & Lawrence M. Page, 2006, Genera of the Asian Catfish Families Sisoridae and Erethistidae (Teleostei: Siluriformes)., pp. 1-96 in Zootaxa 1345 on page 8
Online Iterative Adaptive Dynamic Programming Approach for Solving the Zero-Sum Game for Nonlinear Continuous-Time Systems with Partially Unknown Dynamics
No full textThe current study presents an online iterative adaptive dynamic programming approach to resolve the zero-sum game (ZSG) for nonlinear continuous-time (CT) systems containing a partially unknown dynamic. The Hamilton-Jacobian-Issacs (HJI) equation is solved along the state trajectory according to the value function approximation and the policy improvement online. Relaxed dynamic programming is utilized to ensure the algorithm’s convergence. Model and costate networks were established to conduct the method. Computational simulations are performed to present the efficiency of the algorithm.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Control & Simulatio
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