314 research outputs found
KSL News clip of Mario Capecchi receiving the National Medal of Science for 1991
No full textvideoThis 1 minute, 44 seconds news clip from Salt Lake City\u27s KSLTV, Channel 5 shows Mario Capecchi receiving the National Medal of Science for 1991 from President George W. Bush at the June 13, 2002 awards ceremony. The medal was presented for Capecchi\u27s work in genetics and his development of the process for creating transgenic mice
Cerruti’s treatment of linear elastic trusses
No full textThis paper presents the analysis of linear elastic trusses proposed by Valentino Cerruti in his graduation thesis. While Cerruti is famous among rational mechanicians, very little is known on this work of his. We will consider the work in some detail, putting into evidence the main subjects dealt with by the author: redundant trusses and uniform resistance. We will also provide a comparison with his contemporaries and some critical comments
Une méthode de classification basée sur l'entropie
No full textVittorio Capecchi : Eine auf die Entropie beruhende Klassifizierungsmethode.
Das Problem der Klassifizierung von Individuen, die entsprechend ihren Antworten auf mehrere Entweder-oder-Fragen gekennzeichnet sind, ist von den Biologen verschieden gelöst worden. Der Verfasser analysiert diese Lösungen und zeigt, inwiefern sie für den Soziologen wertvoll sein konnen. Er untersucht nacheinander die Metboden, die auf die Aehnlichkeit der Antworttypen (similarité), auf die Verschiedenheit der Auslesekapazität der Fragen (sélectivité), bzw. auf diese beiden gleichzeitig in Betracht gezogenen Kriterien begrundet sind. Die fur die Selektivität vorgeschlagene Messmethode wertet Techniken aus, die aus der Theorie der Information hergeleitet sind. Der Verfasser führt ein zahlemmässiges Beispiel der letzten Klassifizierungsmethode an und vergleicht seine Resultate mit solchen, die durch die Analyse der latenten Struktur hätten gewonnen werden konnen.Виктор Капечи : Метод классификации, обоснованный на энтропии.
Автор анализирует различные выводы, сделанные биологами по поводу классификации индивидумов, при помощи целой серии ответов на раздвоенные вопросы и указывает на их пользу для социолога. Он исследует последовательно методы классификации, основанные на сходстве типов ответа, на сходстве двух критериев, взятых одновременно. Мероприятия предлагаемого выбора употребляют технику, происходящую из теории информации. Автор представляет числовой пример, иллюстрируя последний метод и сопоставляет, полученную классификацию с той, которая получается после анализа неявной структуры.Vittorio Capecchi : A method of classification based on enthropy.
The author analyses the various solutions biologists have found to the problem of the classification of individuals characterised by a series of answers to dichotomic questions, and points out their value for the sociologist. He examines successively the methods of classifications based on the similarity of types of answers, on the differential selectivity of the questions and on the two criteria considered simultaneously. The proposed measure of selectivity employs technics derived from the information theory. The author gives numerical examples illustrating the last method, and compares the classification obtained with that resulting from the analysis of latent structures.Vittorio Capecchi : Un metodo de clasificación basado en la entropía.
El autor analiza diversas soluciones empleadas por los bíologos en el problema de la clasificación de individuos caracterizados por una serie de respuestas a preguntas dicotómicas, y muestra su utilidad para el sociólogo. Sucesivamente, examina los métodos de clasificación basados en la similitud de los tipos de respuesta, en la selectividad diferenciál de las preguntas y en los dos criterios considerados simultáneamente. La medida de la selectividad propuesta utiliza las técnicas derivadas de la teoría de la información. El autor presenta un ejemplo numérico para ilustrar el ultimo método y compara la clasificación obtenida con la que resulta del análisis de la estructura latente.Capecchi Vittorio. Une méthode de classification basée sur l'entropie. In: Revue française de sociologie, 1964, 5-3. pp. 290-306
A multi-product approach for detecting subjects’ and objects’ covariates in consumer preferences
No full textPurpose – A different framework based on a parametric version of the process generating the hedonic scores is adopted. More precisely, a probability distribution for ordinal responses is proposed as a mixture of two components, denoted as feeling (as expressed preference) and uncertainty component (as inherent indecision). The purpose of this paper is to analyse the effect of covariates on the consumers’ behaviour pattern according to a statistical model. Design/methodology/approach – Sample data come from a multidisciplinary research aimed to improve the quality and marketability of soft fruits. Then, a stochastic model with subjects’ and objects’ covariates is built and the interpretation of significant results is discussed. Findings – The joint effects of personal characteristics and chemical contents of juice on the hedonic scores given by consumers are examined and graphically depicted by means of a significant model. Originality/value – The paper suggests a multi-product approach to expressed hedonic scores by means of a generalization of CUB models
Teza, une grande exploitation théière au Burundi
No full textTeza, a large tea plantation in Burundi.
After having indicated the main characteristics of the principal tea plantation in Burundi, the author invites the reader to discover the various landscapes of the agricultural-industrial complex of Teza during the course of a voyage in which technical details accompany the geographic notations.
In the second part, Monsieur Capecchi takes pains to show how, in spite of average if not even marginal climatic and pedological factors, an agricultural experiment could have been conducted which, before anything else, required of its instigators a great effort at adapting agronomic techniques.
If the Teza tea plantation can be considered a success from the technical point of view, the problems which it poses are above all human : initially parcelled out among many small pilot proprietors, the undertaking has become, due to various technical considerations, a governmental property. The benefits derived, as a consequence, are a source of only meager supplementary income for the local workers.
The long term prospects outlined in the conclusion are particularly favorable and may well make of this large tea plantation of Burundi a model to follow.Après avoir indiqué les caractéristiques essentielles de la principale exploitation théière du Burundi, l'auteur convie le lecteur à découvrir les paysages variés du complexe agro-industriel de Teza au cours d'une promenade où les détails techniques accompagnent les notations géographiques.
Dans la deuxième partie, M. Capecchi s'emploie à exposer comment, en dépit de données climatiques et pédologiques moyennes, voire marginales, a pu être menée une expérience agricole qui a avant tout requis de ses instigateurs un grand effort d'adaptation des techniques agronomiques.
Si l'exploitation de Teza constitue sur le plan technique une grande réussite, les problèmes qu'elle pose sont avant tout humains : originellement lotis entre de multiples petits propriétaires témoins, rentreprise est devenue en raison de considérations techniques diverses, propriété nationale, la plus-value dégagée ne constituant alors qu'une maigre source de revenus additionnels pour les travailleurs locaux.
Les perspectives à long terme dégagées dans la conclusion sont particulièrement favorables et pourraient bien donner à cette grande exploitation théière du Burundi une valeur d'exemple.Capecchi Bernard. Teza, une grande exploitation théière au Burundi. In: Cahiers d'outre-mer. N° 115 - 29e année, Juillet-septembre 1976. pp. 271-301
I falsi per il verosimile e le messinscene del «similvero»: le verità del Re di Girgenti e di alcune indagini di Montalbano.
No full textCamilleri’s works are based on some opposite pairs; one of these can be thoroughly investigated through a comparison between the historical novel Il re di Girgenti and two novels of Montalbano’s series: La caccia al tesoro and Il metodo Catalanotti. In these works, we can find two different types of truth: on the one hand, a strong and moral truth, which the author expresses – it seems a paradox – also through the forgeries he prepared for his historical novel; on the other, a likely but not necessary truth, which emerges from Camilleri’s last detective novels, as sign of author’s skepticism
Three technical reports of R.G. Boscovich on the statics of domes, in: Further Studies in the History of Construction
No full textThe paper presents a comparative analysis of three reports written by Ruggiero Giuseppe Boscovich (1711–1787) on the occasion of the debates which developed, during the eighteenth century, on famous structural disputes: we are referring to Parere for the dome of St. Peter (1742), Scrittura for the Imperial Library of Vienna (1763), and Sentimento for the Cathedral of Milan (1765). In Parere Boscovich proposes the first application of the principle of virtual works (formulated just a few decades earlier by Johann Bernoulli) to the analysis of the stability of a damaged structure with the aim to assess its safety margins and, if the case, define an improvement intervention. A further application is in Sentimento where, however, the purpose is not to analyze a damage state but rather to assess the structural response to a new load condition. Besides the contribution that such an analysis can constitute for the history of mechanics, the importance of the three reports – even though characterized by significant differences, related not only to the specific problems but also to the scientific growth of Boscovich – is that, for the first time in the history of architecture, we are in the presence of a systematic treatment of mechanical problems aimed at a rational justification of architectural interventions. Therefore, in addition to their scientific value, which can be summed up in the methodological cogency and the thorough discussion of mechanical issues, the three reports allow reflecting, even though marginally, on the complex relationship between science and architecture which, just in the eighteenth century, shows a growing involvement of knowledge of statics in building design.The paper presents a comparative analysis of three reports written by Ruggiero Giuseppe Boscovich (1711–1787) on the occasion of the debates which developed, during the eighteenth century, on famous structural disputes: we are referring to Parere for the dome of St. Peter (1742), Scrittura for the Imperial Library of Vienna (1763), and Sentimento for the Cathedral of Milan (1765). In Parere Boscovich proposes the first application of the principle of virtual works (formulated just a few decades earlier by Johann Bernoulli) to the analysis of the stability of a damaged structure with the aim to assess its safety margins and, if the case, define an improvement intervention. A further application is in Sentimento where, however, the purpose is not to analyze a damage state but rather to assess the structural response to a new load condition. Besides the contribution that such an analysis can constitute for the history of mechanics, the importance of the three reports – even though characterized by significant differences, related not only to the specific problems but also to the scientific growth of Boscovich – is that, for the first time in the history of architecture, we are in the presence of a systematic treatment of mechanical problems aimed at a rational justification of architectural interventions. Therefore, in addition to their scientific value, which can be summed up in the methodological cogency and the thorough discussion of mechanical issues, the three reports allow reflecting, even though marginally, on the complex relationship between science and architecture which, just in the eighteenth century, shows a growing involvement of knowledge of statics in building design
Circulating extracellular vesicles and cytokines in congenital and acquired hemolytic anemias
No full textFormation professionnelle et petite entreprise : le développement industriel à spécialisation flexible en Émilie-Romagne
No full textVittorio Capecchi, Berufliche Ausbildung und Kleinunternehmen : die industrielle Entwicklung mit flexibler Spezialisierung in der Emilia - Romagna.
Der Aufsatz behandelt die Charakteristika und das Verhalten der Kleinunternehmen in einem andersartigen Industrialisierungsprozess als dem gewöhnlichen Modell - dem Fordismus. Im Fordismus steht das Kleinunternehmen meistens in einem Abhängigkeitsverhältnis gegenüber dem Grossunternehmen. Im Industrialisierungssystem mit flexibler Spezialisierung gehört dagegen das Kleinunternehmen einem Teilsystem, das in der den Forderungen der Kunden angepassten kleinen Serienproduktion spezialisiert ist. Dieses Teilsystem besteht aus einem Netz von Kleinunternehmen ohne Führung. Der Autor beschreibt den Entstehungsprozess eines derartigen Netzes in der Emilia - Romagna und hebt die historischen Faktoren wirtschaftlicher, gesellschaftlicher und politischer Natur hervor, die erklàren, weshalb das System sich in dieser Gegend Italiens so entwickelt hat. Die wichtigsten Kennzeichen dieser Industriali- sierung werden untersucht : Beziehungen zwischen den Unter- nehmen, technologische Ubertragungen, typische Merkmale der Unternehmensleiter, berufliche Ausbildung der Arbeiter. Der Autor priift weiterhin, wie dieses auf kleinen Einheiten beruhende System mit der durch EDV entstandenen Umwalzung konfrontiert wird, während die Grossunternehmen selbst sich der flexibleren kleinen Serienproduktion zuwenden. Besonders hervorgehoben werden die heute gestellten Probleme der Berufsausbildung und die vorgeschlagenen Lösungen im Rahmen der Regionalpolitik Italiens.Vittorio Capecchi, Vocational training and small firms : Flexible-specialization industrial development in Emilia-Romagna.
This article deals with the characteristics and performance of the small firm in a type of organization different from the Fordian system generally presented. In the latter system, a small firm is most frequently dependently linked to a large one. On the contrary, in the flexible specialization system, the small firm is part of a sub-system specializing in the manufacture of small lines meeting the customer's requirements. This sub-system is made up of a network of small firms, without a leader firm. The author describes the process by which such a network was formed in Emilia-Romagna, and shows up the historical factors-both economic, social and political - which explain why it developed in this region of Italy. The main characteristics of this type of organization are studied : inter-firm relationships, transfer of technology, profiles of works managers, workers' vocational training. The author then examines how this system of small units is confronting the electronics and computer revolution, at a time when large firms are, themselves, seeking to produce small, flexible lines. Emphasis is laid on current problems of vocational training, and on the solutions proposed in the context of Italian regional policy.L'article traite des caractéristiques et du comportement de la petite entreprise dans un type d'industrialisation différent du modèle habituellement présenté, le fordisme. Dans ce dernier, la petite entreprise est le plus souvent placée dans un lien de dépendance à l'égard de la grande entreprise. À l'opposé, dans le système d'industrialisation à spécialisation flexible, la petite entreprise fait partie d'un sous-système spécialisé dans la production de petites séries répondant aux exigences du client. Ce sous-système est formé d'un réseau de petites entreprises, sans entreprise leader. L'auteur décrit le processus de formation d'un tel réseau en Émilie-Romagne, et met en relief les facteurs historiques, d'ordre économique, social et politique, qui expliquent pourquoi il s'est développé dans cette région de l'Italie. Les principales caractéristiques de ce type d'industrialisation sont étudiées : relations entre les entreprises, transferts de technologie, profils des chefs d'entreprise, formation professionnelle des ouvriers. L'auteur examine ensuite comment ce système de petites unités affronte la révolution électronique et informatique, à un moment où les grandes entreprises cherchent elles-mêmes à produire des petites séries flexibles. L'accent est mis sur les problèmes de la formation professionnelle qui se posent actuellement, et sur les solutions proposées dans le cadre de la politique régionale italienne.Capecchi Vittorio, Costa G., Novelli Annie. Formation professionnelle et petite entreprise : le développement industriel à spécialisation flexible en Émilie-Romagne. In: Formation Emploi. N.19, 1987. pp. 3-18
Characterization of vaccine antigens of meningococcal serogroup W isolates from Ghana and Burkina Faso from 2003 to 2009
No full textNeisseria meningitidis is a major cause of bacterial meningitis and a considerable health problem in the 25 countries of the 'African Meningitis Belt' that extends from Senegal in West Africa to Ethiopia in the East. Approximately 80% of cases of meningococcal meningitis in Africa have been caused by strains belonging to capsular serogroup A. After the introduction of a serogroup A conjugate polysaccharide vaccine, MenAfriVac (™), that began in December 2010, the incidence of meningitis due to serogroup A has markedly declined in this region. Currently, serogroup W of N. meningitidis accounts for the majority of cases. Vaccines based on sub-capsular antigens, such as Generalized Modules for Membrane Antigens (GMMA), are under investigation for use in Africa. To analyse the antigenic properties of a serogroup W wave of colonisation and disease, we investigated the molecular diversity of the protein vaccine antigens PorA, Neisserial Adhesin A (NadA), Neisserial heparin-binding antigen (NHBA) and factor H binding protein (fHbp) of 31 invasive and carriage serogroup W isolates collected as part of a longitudinal study from Ghana and Burkina Faso between 2003 and 2009. We found that the isolates all expressed fHbp variant 2 ID 22 or 23, differing from each other by only one amino acid, and a single PorA subtype of P1.5,2. Of the isolates, 49% had a functional nhbA gene and 100% had the nadA allele 3, which contained the insertion sequence IS1301 in five isolates. Of the W isolates tested, 41% had high fHbp expression when compared with a reference serogroup B strain, known to be a high expresser of fHbp variant 2. Our results indicate that in this collection of serogroup W isolates, there is limited antigenic diversification over time of vaccine candidate outer membrane proteins (OMP), thus making them promising candidates for inclusion in a protein-based vaccine against meningococcal meningitis for Africa
- …
