416 research outputs found
Nanocapsules with stimuli-responsive moieties for controlled release employing light and enzymatic triggers
No full textThe development of stimuli-responsive nanomaterials, that possess tailored functional properties for the release of specific compounds, is of particular interest. To this extent, controlling the release of molecules at the desired target is an important parameter to regulate chemical and/or biological reactions at a more profound level in a wide variety of applications. In the present work, we report on the development of dual-responsive thiourethane-urethane nanocapsules synthesizedviaan interfacial polymerization reaction executed at the droplet interface using the inverse miniemulsion technique. Evidenceviamorphological and controlled release investigations indicate that our nanocapsules are able to encapsulate hydrophilic compounds with high efficiency in their aqueous core and allow for its selective release upon exposure to UV light and the enzyme esterase. Moreover, we demonstrate the efficient encapsulation of the fragrance molecule geranyl acetate and the anticancer drug doxorubicin. For the latter, we demonstrate its apoptotic effect after being released in MCF 7 breast cancer cells. Overall, these nanocapsules can be used for a wide variety of applications where a selective release of the payload is desired.S. S. is an SB PhD Fellow at the FWO (Research Foundation Flanders). S. K. P. acknowledges BOF funding from Hasselt University. This work is supported by Hasselt University and the Research Foundation Flanders (FWO Vlaanderen; Hercules project AUHL/15/2 - GOH3816N). The authors are thankful to Prof. M. Van Bael for access to the DLS device.Pramanik, SK; Ethirajan, A (corresponding author), Hasselt Univ, Inst Mat Res IMO, Wetenschapspk 1 & Agoralaan D, B-3590 Diepenbeek, Belgium; IMEC, Associated Lab IMOMEC, Wetenschapspk 1, B-3590 Diepenbeek, Belgium;
CSIR Cent Salt & Marine Chem Res Inst, Bhavnagar 364002, Gujarat, India.
[email protected]; [email protected]
Redox-Responsive Nanocapsules for the Spatiotemporal Release of Miltefosine in Lysosome: Protection against Leishmania
No full textLeishmaniasis, a vector-borne disease, is caused by intracellular parasite Leishmania donovani. Unlike most intracellular pathogens, Leishmania donovani are lodged in parasitophorous vacuoles and replicate within the phagolysosomes in macrophages. Effective vaccines against this disease are still under development, while the efficacy of the available drugs is being questioned owing to the toxicity for nonspecific distribution in human physiology and the reported drug-resistance developed by Leishmania donovani. Thus, a stimuli-responsive nanocarrier that allows specific localization and release of the drug in the lysosome has been highly sought after for addressing two crucial issues, lower drug toxicity and a higher drug efficacy. We report here a unique lysosome targeting polymeric nanocapsules, formed via inverse mini-emulsion technique, for stimuli-responsive release of the drug miltefosine in the lysosome of macrophage RAW 264.7 cell line. A benign polymeric backbone, with a disulfide bonding susceptible to an oxidative cleavage, is utilized for the organelle-specific release of miltefosine. Oxidative rupture of the disulfide bond is induced by intracellular glutathione (GSH) as an endogenous stimulus. Such a stimuli-responsive release of the drug miltefosine in the lysosome of macrophage RAW 264.7 cell line over a few hours helped in achieving an improved drug efficacy by 200 times as compared to pure miltefosine. Such a drug formulation could contribute to a new line of treatment for leishmaniasis.A. Das acknowledges SERB (India) Grants (CRG/2020/000492 and JCB/2017/000004) and DBT Grant (BT/PR22251/NNT/28/1274/2017) for supporting this research. N. Mukherjee acknowledges SERB (India) Grant PDF/2016/001437 and K. Das acknowledges the grant EMR/2015/001674 for supporting this research. Financial support from DST (DST/INSPIRE/03/2017/002477) is acknowledged by R.T. This manuscript bears CSMCRI registration no 7/2021.Pramanik, SK (corresponding author), CSIR Cent Salt & Marine Chem Res Inst, Bhavnagar 364002, Gujarat, India.
Mukherjee, N (corresponding author), CSIR Indian Inst Chem Biol, Canc Biol & Inflammatory Disorder Div, Kolkata 700032, India.
Chattopadhy, S (corresponding author), BITS Pilani, Pilani 403726, Goa, India.
Das, A (corresponding author), Indian Inst Sci Educ & Res Kolkata, Mohanpur 741246, W Bengal, India.
[email protected]; [email protected]; [email protected]
PEGylating poly(p-phenylene vinylene)-based bioimaging nanoprobes
No full textHypothesis: Conjugated polymer nanoparticles (CNPs) have attracted considerable attention within bioimaging due to their excellent optical properties and biocompatibility. However, unspecific adsorption of proteins hampers their effective use as advanced bioimaging probes. Controlled methodologies made possible tailor-made functional poly(p-phenylene vinylene), enabling one-pot synthesis of CNPs containing functional surface groups. Hence, it should be feasible to PEGylate these CNPs to tune the uptake by cell lines representative for the brain without imparting their optical properties. Experiments: CNPs consisting of the statistical copolymer 2-(50-methoxycarbonylpentyloxy)-5-methoxy-1,4-phenylenevinylene and poly(2-methoxy-5-(30,70-dimethoxyoctyloxy)-1,4-phenylenevinylene) were fabricated by miniemulsion solvent evaporation technique. Surface carboxylic acid groups were used to covalently attach amine-terminated polyethylene glycol (PEG) of different molecular weights. We investigated the effect of grafting CNPs with PEG chains on their intrinsic optical properties, protein adsorption behavior and uptake by representative brain cell lines. Findings: PEGylation did not affect the optical properties and biocompatibility of our CNPs. Moreover, a significant decrease in protein corona formation and unspecific uptake in central nervous system cell lines, depending on PEG chain length, was observed. This is the first report indicating that PEGylation does not affect the CNPs role as excellent bioimaging tools and can be adapted to tune biological interactions with brain cells. (C) 2020 Elsevier Inc. All rights reserved.Support for confocal microscopy was given by Prof. dr. Marcel Ameloot and Dr. Hannelore Bove. Cells were kindly provided by Prof. dr. Annelies Bronckaers, Dr. Jo Mailleux and dra. Jasmine Vanmol. Technical support was given by Huguette Penxten, Christel Bocken and Erik Royackers. Dr. Neomy Zaquen is acknowledged for the synthesis of the conjugated polymers. MP is grateful for funding from the IWT (Agentschap voor Innovatie door Wetenschap en Technologie). SS is an SB PhD Fellow at the Research Foundation Flanders (FWO). The work was funded by the Belgian Charcot Foundation. TJ is grateful for funding from the FWO in the form of an Odysseus grant. This work was supported by Hasselt University and the Research Foundation Flanders (FWO Vlaanderen; Hercules project AUHL/15/2 -GOH3816N). Additional support from BELSPO in the form of the interuniversity attraction pole (IAP) program P7/05: Functional Supramolecular Systems is kindly acknowledged. We further acknowledge the Hercules Foundation for the project (LC-MS@UHasselt: Linear Trap QuadrupoleOrbitrap mass spectrometer.Ethirajan, A (corresponding author), Hasselt Univ, Inst Mat Res, Wetenschapspk 1, B-3590 Diepenbeek, Belgium.
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Invariant submanifolds of Sasakian manifolds admitting semi-symmetric non-metric connection, communicated
No full textThe object of this paper is to study invariant submanifolds M of Sasakian manifolds M admitting a semisymmetric nonmetric connection, and it is shown that M admits semisymmetric nonmetric connection. Further it is proved that the second fundamental forms σ and σ with respect to Levi-Civita connection and semi-symmetric nonmetric connection coincide. It is shown that if the second fundamental form σ is recurrent, 2-recurrent, generalized 2-recurrent, semiparallel, pseudoparallel, and Ricci-generalized pseudoparallel and M has parallel third fundamental form with respect to semisymmetric nonmetric connection, then M is totally geodesic with respect to Levi-Civita connection. Semisymmetric Nonmetric Connection The geometry of invariant submanifolds M of Sasakian manifolds M is carried out from 1970's by M. Kon 1 , D. Chinea 2 , K. Yano and M. Kon 3 and B.S. Anitha and C.S. Bagewadi 4 . The aurthor 1 has proved that invariant submanifold of Sasakian structure also carries Sasakian structure. In this paper we extend the results to invariant submanifolds M of Sasakian manifolds admitting Semisymmetric Nonmetric connection. We know that a connection ∇ on a manifold M is called a metric connection if there is a Riemannian metric g on M if ∇g 0; otherwise it is Nonmetric. Further it is said to be Semisymmetric if its torsion tensor T X, Y 0; thatis, T X, Y w Y X − w X Y , where w is a 1-form. A study of Semisymmetric connection on a Riemannian manifold was initiated by Yano 5 . In 1992, Agashe and Chafle 6 introduced the notion of Semisymmetric Nonmetric connection. If ∇ denotes Semisymmetric Nonmetric connection on a contact metric manifold
Power relations Vs Personal Relations in the Selected Translations of O.Chandu Menon’s Indulekha
No full textThe novel has three English translations. The first English version was by John Willoughby Francis Dumergue, a friend of O. Chandu Menon. The latest one was by Dr. Anitha Devassia. The novel had several novelties in terms of theme and technique though Chandu Menon was trying to ‘translate’ an alien genre to Malayalam literature. Anitha Devasia’s translation came more than hundred years after the publication of the original and Dumergue’s translation. This paper intends to analyze the two translations to identify the translator more representative of the author using Bourdieu’s concept of habitus. Bourdieu defines habitus as “a general, transposable disposition, which carries out a systematic, universal appreciation - beyond the limits of what has been directly learnt- of the necessity inherent in learning conditions
Synthesis, crystal growth and characterization of bioactive material: 2-amino-1H-benzo[d]imidazol-3-ium salicylate single crystal-a proton transfer molecular complex
No full textA study on Accounting students' perception on employability skills in University of Technology and Applied Sciences, Muscat
No full textAbstract: Universities are expected to contribute the economic growth of the country by preparing the graduates with necessary academic skills. Students are focusing more on knowledge or the course contents but put less effort on the skill that are inventible for them to master in their chosen field. This study is focusing on the perception of accounting graduates of UTAS about employability skill that they should possess. The study found that the students feel Learning and Development skills are not necessary for employability irrespective of gender or the year of study. Learning and Development skills include working in teams, able to adapt technology, communication skills, lifelong learning and problem solving skills. When subject knowledge is compared with the year of study, the authors found that the students did not give importance to subject knowledge as well. However, Life/Career skills are considered to be valuable skills by the students whether it is compared with gender or year of study. The authors recommend that the students must be educated on the importance of Learning and development skills and subject knowledge, which will help them in securing a good job in the future. It will also help to solve the unemployment problems in the society.
Keywords: Employability skills, subject knowledge, students, University, Accounting, Unemployment problems.
Title: A study on Accounting students’ perception on employability skills in University of Technology and Applied Sciences, Muscat
Author: Dr. Anitha Ravikumar, Mr. Gopalan Puthukulam, Dr. Anupam Sharma
International Journal of Recent Research in Commerce Economics and Management (IJRRCEM)
ISSN 2349-7807
Vol. 9, Issue 3, July 2022 - September 2022
Page No: 145-149
Paper Publications
Website: www.paperpublications.org
Published Date: 23-September-2022
DOI: https://doi.org/10.5281/zenodo.7108137
Paper Download Link (Source)
https://www.paperpublications.org/upload/book/A%20study%20on%20Accounting%20students-23092022-6.pdfInternational Journal of Recent Research in Commerce Economics and Management (IJRRCEM), ISSN 2349-7807, Paper Publications, Website: www.paperpublications.or
The effect of 12-week step and floor aerobic exercise programs on physical and psychophysiological health parameters in obese men
No full textAerobic exercise training is recommended to prevent and control obesity. The present study aimed to evaluate the effectiveness of a twelve-week step aerobics or floor aerobics exercise program in improving the physical and psychophysiological health of obese men. Sixty male adults of mean age 18.92 (SD 1.54 years) and Body Mass Index (BMI) ≥ 30 kg/m2 were randomly allocated into three equal (n = 20) groups: Step Aerobics Exercise Training (SAET), Floor Aerobic Exercise Training (FAET), and a control group (which did not perform any exercise). The SAET and FAET training protocols were performed three days per week for 12 weeks. Health-related physical fitness, biochemical, physiological, and psychological variables were used as outcome measures and measured at baseline and at 12 weeks. There were significant differences in terms of physical and psychophysiological health parameters in participants who underwent SAET and FAET training compared with the control group (p < 0.05). SAET and FAET proved to be helpful in managing the physical and psychological health of obese adults. Schools and colleges should administer aerobic exercise sessions to adults for better health perspectives.Ćwiczenia aerobowe zalecane są w celu zapobiegania i kontrolowania nadwagi i otyłości. Niniejsze badanie miało na celu ocenę skuteczności dwóch 12-tygodniowych programów ćwiczeń aerobowych w poprawie stanu zdrowia fizycznego i psychofizjologicznego otyłych mężczyzn. Sześćdziesięciu dorosłych mężczyzn w średnim wieku 18,92 (SD 1,54 lat) i wskaźniku masy ciała (BMI) ≥ 30 kg/m2 zostało losowo przydzielonych do trzech równych (n = 20) grup: trening aerobowy z wykorzystaniem stepów (SAET), trening aerobowy bez stepów (FAET) lub grupa kontrolna (która nie podejmowała aktywności fizycznej). Procedury treningowe SAET i FAET wykonywano trzy dni w tygodniu przez 12 tygodni. Wybrane parametry zdrowotne (fizyczne i psychofizjologiczne) oceniono na początku badania i po 12 tygodniach. Stwierdzono istotne różnice w zakresie parametrów zdrowia fizycznego i psychofizjologicznego u uczestników, którzy przeszli trening SAET i FAET w porównaniu z grupą kontrolną (p < 0,05). SAET i FAET okazały się pomocne w poprawie zdrowia fizycznego i psychicznego otyłych mężczyzn. Aby uzyskać lepsze perspektywy zdrowotne, szkoły i uczelnie wyższe powinny organizować sesje ćwiczeń aerobowych dla dorosłych
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