10 research outputs found
Deiscenza del nervo faciale in pazienti con otite media purulenta cronica e colesteatomatosa.
No full text
Nostra esperienza nella diagnosi e nel trattamento delle fistole labirintiche in pazienti con otite media purulenta cronica.
No full textAltered microRNA, mRNA, and Protein Expression of Neurodegeneration-Related Biomarkers and Their Transcriptional and Epigenetic Modifiers in a Human Tau Transgenic Mouse Model in Response to Developmental Lead Exposure
No full textDicronychus brancuccii Platia and Schimmel 1997
No full textDicronychus brancuccii Platia and Schimmel, 1997 Figs. 1–5 Material examined: Sultanate of Oman: Dhofar Region, Salalah, 16 ° 59 ’N, 54 ° 64 ’E, 10 m, 19–20.VII- 1995, B. Skule (1 ♀ paratype NHMB); Saudi Arabia: Wadi Marwani, 7 -II- 1985, W. Buttiker, (1 paratype, NHMB); Makkah, Wadi Shuque, 20 ° 44 ’N, 41 ° 09’E, 1380 m. 12 -IX- 1984 W. Buttiker, (1 paratype, NHMB); Muzahimiyah, AlKhararah 24 ° 24 ’ 24 ”N, 46 ° 14 ’ 40 ” E, 26 -IV- 2012 light trap, Y. Drayhim, H. Al Dhafer, A. Al Gharbawy & M. Al Harbi, 1 ♀ (KSMA); Wadi Qounonah, 19 ° 24 ’ 673 ”N, 41 ° 36 ’ 388 ” E, 348m, 11 III 2012, light trap, H. Al Dhafer & H. Fadl, 2 ♂, 2 ♀ (KSMA); AlMajardah, Wadi AlTalalie, 19 ° 05’ 192 ”N, 41 ° 47 ’ 784 ”E, 286m, 1 VI 2012, 1♂, 2 ♀ (KSMA), sweeping, H. Al Dhafer & B. Kondratieff; 1 ♀ (KSMA); same locality, A. AlAnsi, 1 ♀ (KSMA); Rawdhat Khorim, 25 ° 25 ’ 943 ”N, 47 ° 13 ’ 863 ” E, 572m, 26 -IV- 2011 light trap, 1 ♀ (KSMA); Jizan, Aiban, Sabia Road, Wadi Shahdan, 17 ° 28 ’ 266 ”N, 42 ° 51 ’ 191 ”E, altitude 433m, 13 -XI- 2012, light trap, H. Al Dhafer, 1 ♂ (KSMA). Description. Head: Black with dense small punctures mixed with larger punctures (Fig. 1), covered with dense erect pale setae; frons convex becoming flat toward anterior margin with well-developed apical carina; antennae not reaching the hind angles by about one antennomere, antennomere 2 subconical, slightly shorter than antennomere 3; antennomeres 3–10 feebly dilated at apex, longer than wide; antennomere 11 subellipsoidal, narrowed at apex. Pronotum: as long as wide, convex, widest at middle, black, dense and fine round punctures alternating with larger round punctures, lateral margins arcuate; hind angles sharply truncate, carinate dorsally. Prosternum with impressed V-shaped lines (Fig. 2). Scutellum: Black, slightly wider than long, heart shaped, emarginated at base. Elytra: Bicolored, yellowish brown, medially black (Fig. 3); striae finely punctuate, interstriae deeply punctuate. Male genitalia: Parameres of aedeagus with a distinct produced subapical rounded lateral lobe, apical expansion triangular, two setae below expansion, distal setae long; median lobe simple, clublike, subparallel margins beyond middle, apically rounded, not bulbous (Fig. 4). Female genitalia: Proximal sclerite of bursa copulatrix (Fig. 5) with 11–13 large marginal teeth and 14–16 smaller teeth including one below large marginal terminal tooth. Remarks. The proximal sclerite of the bursa copulatrix (Fig. 5) in D. brancuccii easily distinguishes it from the two new species described below. The male can be distinguished by the parameres possessing a distinctly produced subapical rounded lateral lobe with the apical expansion triangular in shape (Fig. 4). Additionally, the median lobe of the aedeagus has a clublike apex (Fig. 4).Published as part of Al Dhafer, Hathal M. & Platia, Giuseppe, 2013, Contribution to the knowledge of the genus Dicronychus (Coleoptera: Elateridae) from the Kingdom of Saudi Arabia, pp. 15-22 in Zootaxa 3734 (1) on page 16, DOI: 10.11646/zootaxa.3734.1.2, http://zenodo.org/record/28516
Tolfenamic Acid Derivatives: A New Class of Transcriptional Modulators with Potential Therapeutic Applications for Alzheimer’s Disease and Related Disorders
No full textThe field of Alzheimer’s disease (AD) has witnessed recent breakthroughs in the development of disease-modifying biologics and diagnostic markers. While immunotherapeutic interventions have provided much-awaited solutions, nucleic acid-based tools represent other avenues of intervention; however, these approaches are costly and invasive, and they have serious side effects. Previously, we have shown in AD animal models that tolfenamic acid (TA) can lower the expression of AD-related genes and their products and subsequently reduce pathological burden and improve cognition. Using TA as a scaffold and the zinc finger domain of SP1 as a pharmacophore, we developed safer and more potent brain-penetrating analogs that interfere with sequence-specific DNA binding at transcription start sites and predominantly modulate the expression of SP1 target genes. More importantly, the proteome of treated cells displayed ~75% of the downregulated products as SP1 targets. Specific levels of SP1-driven genes and AD biomarkers such as amyloid precursor protein (APP) and Tau proteins were also decreased as part of this targeted systemic response. These small molecules, therefore, offer a viable alternative to achieving desired therapeutic outcomes by interfering with both amyloid and Tau pathways with limited off-target systemic changes
Minbar al-Sharq, No.349 (vol. 24, Mar. 30, 1945)
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