4 research outputs found
Copper-mediated rapid and facile oxidative dehydrogenation of dihydrobenzocarbazoles
No full textRapid method for the oxidative dehydrogenation of dihydrobenzocarbazoles has been introduced by using bench scale and commercially available reagent; copper chloride, in excellent yield with easy workup. The scope of the reaction has been studied with broad range of substitutes</p
A One-Pot Direct Iodination of the Fischer–Borsche Ring Using Molecular Iodine and Its Utility in the Synthesis of 6‑Oxygenated Carbazole Alkaloids
No full textAn
efficient regioselective iodination of the Fischer–Borsche
ring has been achieved using molecular iodine, in a one-pot synthesis.
The acid-, metal-, and oxidant-free conditions of the present method
are highly convenient and practical. Furthermore, the one-pot direct
iodination process is extended to the concise synthesis of glycozoline,
3-formyl-6-methoxy-carbazole, and 6-methoxy-carbazole-3-methylcarboxylate
natural alkaloids. This method has been proven to be tolerant to a
broad range of functional groups, with good to excellent yields
Radical Beckmann Rearrangement and Its Application in the Formal Total Synthesis of Antimalarial Natural Product Isocryptolepine via C–H Activation
No full textThe
Beckmann rearrangement of ketoximes, mediated by ammonium persulfate-dimethyl
sulfoxide as a reagent, has been achieved under neutral conditions.
Based on the radical trapping and 18O-labeling experiments,
the transformation follows a mechanism involving a radical pathway.
The scope and generality of the developed protocol has been demonstrated
by 19 examples. The developed protocol and Pd-catalyzed intramolecular
double C–H activation were used as key steps in the formal
total synthesis of antimalarial natural product isocryptolepine
Transition-Metal-Free Regioselective One-Pot Synthesis of Aryl Sulfones from Sodium Sulfinates via Quinone Imine Ketal
No full textA novel, efficient,
and regioselective transition-metal-free one-pot
synthesis of aryl sulfones via the reactive quinone imine ketal intermediate
is demonstrated using easily accessible bench-stable sulfinate salts.
A broad range of functionality on p-anisidine substrates
as well as sulfinate salts was tolerated under mild reaction conditions
to provide the corresponding aryl sulfones in good to excellent yields
