1,721,022 research outputs found
A clinical radiographic and histologic revaluation of a 10 years sample of surgically treated cysts of the jaws, with special emphasis on keratocysts.
No full textThe aim of this study was to compare the histologic features of the cysts as regards their radiographic and clinical aspects, in order to assess the accuracy of the diagnosis, the appropriateness of the treatment and the reliability of the follow-up. A sample of 173 cysts of the jaws was reviewed in accordance with the 1992 WHO histological classification. Of these cysts, 77.44% were inflammatory, 12.71% follicular and 8.67% keratocysts. The cysts were slightly more frequently located in the mandible (52.60%) than in the maxilla (47.39%) and they affected men more frequently (60.11%) than women (39.88%). However keratocysts and nasopalatine cysts were twice as frequent in women than in men. No recurrence of keratocysts was found, either in those correctly diagnosed at the moment of the first histologic examination, or in those firstly erroneously diagnosed as an other type of cysts. On the basis of the fairly high percentage of non-inflammatory cysts in adult patients, it can be suggested to perform an orthopantomography as a preventive measure, every 5 years, particularly when impaired teeth are present
Immunohistopathogenesis of persistent generalized lymphadenopathy in HIV-positive patients
No full textPersistent generalized lymphadenopathy (PGL) is a reactive lymphadenitis affecting HIV-positive patients; furthermore, PGL is often a prodrome of AIDS-related complex and AIDS. In the present review the authors describe the histology and the immunohistochemistry of lymph nodes of patients affected by PGL. Histologic alterations of lymph nodes with PGL are classified according to three main types: follicular hyperplasia without or with follicular fragmentation, follicular involution and follicular depletion. Immunohistology demonstrates a peculiar infiltration of CD3+/CD4+ and CD3+/CD8+ lymphocytes in germinal centers; CD3+/CD8+ are often grouped in small clusters centered by a newly formed small blood vessel. Accessory follicular dendritic reticulum cells (FDRCs) of germinal centers are characterized by a positive staining for p24 and p19 HIV major core antigens. In germinal centers, FDRCs undergo progressive lysis in follicular involution and in follicular depletion. Other viral antigens, such as EBV, are infrequently seen in lymph nodes from HIV-positive patients. Paracortical areas of lymph nodes are often characterized by prominent postcapillary venule proliferations and by hyperplasia of the endothelial cells which are HLA-DR positive, often p19 and p24 positive, and occasionally express HIV genome. In conclusion, in PGL the histologic changes correlate well with the immunohistologic features; accordingly, PGL might be considered the result of abnormal immune reactions to several stimuli still incompletely known. © 1990 Springer-Verlag
IL-12 RELATED CYTOKINE GENE EXPRESSION IN CARCINOMAS OF THE LARYNX. A STUDY AT TISSUE LEVEL.
No full textIn the present study the authors have evaluated at tissue level the gene expression of IL-12, IL-2 and IL-4, in order to asses the functional phenotype of Tumour Infiltrating Lymphocytes in head and neck squamous cell carcinomas. The distribution of lymphocytes present within the neoplastic tissue of larynx carcinomas indicate that these neoplasms are able to induce predominantly Th1 heper lymphocytes
Hibernoma of the para-glottic space: an unusual tumour of the larynx.
No full textHibernoma is an unusual tumour of brown adipose tissue. Brown adipose tissue is common in mammalian hibernating animals and acts as a thermogenic organ. A first case of hibernoma was reported in 1906 by Merkel. This tumour usually arises in the back, shoulder region, mediastinum, retroperitoneum and in the neck. The neck location of hibernomas is rare and only 18 cases of cervical hibernoma have been reported in the English literature. A 48-year-old male with hoarseness and soft voice, present for 8 months, showed a lesion involving the anterior part of the right vocal fold, with no impaired mobility. This is the first case to be reported of laryngeal hibernoma located in a vocal fold, originating from the white fat tissue of the paraglottic space. Moreover, this report could be evidence of the development of hibernoma from white adipose tissue
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