45 research outputs found

    Family history of first degree as a risk factor for colorectal cancer

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    Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/ 01903-Valencia, PS09/02078-Huelva, PS09/01662-Granada, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI17CIII/00034); CIBERESP CB06/02/0073, cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER); la Comisión Europea de subvenciones FOOD-CT-2006-036224-HIWATE (...)Rubín-García, M., Martín, V., Vitelli-Storelli, F., Moreno, V., Aragonés, N., Ardanaz, E., Alonso-Molero, J., Jiménez-Moleón, J.J., Amiano, P., Fernández-Tardón, G., Molina-Barceló, A., Alguacil, J., Dolores-Chirlaque, M., Álvarez-Álvarez, L., Pérez-Gómez, B., Dierssen-Sotos, T., Olmedo-Requena, R., Guevara, M., Fernández-Villa, T., Pollán, M., Benavente, Y

    Compositional analysis of dietary patterns

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    Solans, M., Coenders, G., Marcos-Gragera, R. , Castelló, A., Gràcia-Lavedan, E. , Benavente, Y., Moreno, V., Pérez-Gómez, B., Amiano, P. , Fernández-Villa, T. , Guevara, M., Gómez-Acebo, I., Fernández-Tardón, G. , Vanaclocha-Espi, M. , Chirlaque, M.D., Capelo, R., Barrios, R., Aragonés, N. , Molinuevo, A., Vitelli-Storelli, F., Castilla, J., Dierssen-Sotos, T. , Castaño-Vinyals, G. , Kogevinas, M., Pollán, M., Saez, M

    Relationship between the risk of gastric cancer and adherence to the mediterranean diet according to different estimators. MCC—Spain study

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    The study was partially funded by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on 11 October 2007; by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078- Huelva, PS09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI17CIII/00034); by the Fundación Marqués de Valdecilla (API 10/09); by the ICGC International Cancer Genome Consortium CLL (the ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)); by the Junta de Castilla y León (LE22A10-2); by the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-0306-2011, salud201200057018tra); by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10); by the Recercaixa (2010ACUP 00310); by the Regional Government of the Basque Country; by the Consejería de Sanidad de la Región de Murcia; by the European Commission grants FOOD-CT-2006-036224-HIWATE; by the Spanish Association Against Cancer (AECC) Scientific Foundation—grant GCTRA18022MORE; by the Catalan Government—Agency for Management of University and Research Grants (AGAUR) grants 2017SGR723 and 2014SGR850; by the Fundación Caja de Ahorros de Asturias; and by the University of Oviedo. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. M Obón-Santacana received a post-doctoral fellowship from the Spanish Association Against Cancer (AECC) Scientific Foundation. M Obón-Santacana is part of group 55 of CIBERESP and AGAUR 2017SGR723. M. R-G. is supported by the Ministry of Education of Spain (FPU17/06488).Álvarez-Álvarez L, Vitelli-Storelli F, Rubín-García M, Aragonés N, Ardanaz E, Castaño-Vinyals G, Obón-Santacana M, Dierssen-Sotos T, Salas-Trejo D, Tardón A, Moleón JJJ, Alguacil J, Chirlaque MD, Pérez-Gómez B, Pollán M, Kogevinas M, Martín

    Validation of self-reported perception of proximity to industrial facilities: MCC-Spain study

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    Thisstudy was funded by:Scientific Foundation of the Spanish Association Against Cancer (Fundación Científica de la Asociación Española Contra el Cáncer(AECC)– EVP-1178/14), Spain's Health Research Fund (Fondo de Investigación Sanitaria–FIS12/01416),the Spanish Ministry of Economy and Competitiveness (Carlos III Institute of Health; PI12/00488, PI12/00265, PI12/01270, PI12/00715,PI12/00150,PI08/1770,PI08/0533,PI08/1359,PS09/00773,PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403,PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI14/01219 and Río Hortega CM13/00232),the Catalan Government 2009 SGR1489&2014SGR756-F,the Fundación Marqués de Valdecilla(API10/09),the ICGC International Cancer Genome Consortium CLL, the Junta de Castilla y León (LE22A10-2), the Consejería de Salud of the Junta de Andalucía (PI-0571), the Conselleria de Sanitat of the Generalitat Valenciana (AP 061/10), the Recercaixa (2010ACUP 310), and the Regional Government of the Basque Country by European Commission grants FOOD-CT-2006-036224-HIWATECastello, A; Perez-Gomez, B; Lora-Pablos, D; Lope, V; Castano-Vinyals, G; Vitelli-Storelli, F; Dierssen-Sotos, T; Amiano, P; Guevara, M; Moreno, V; Lozano-Lorca, M; Tardon, A; Alguacil, J; Hernandez-Garcia, M; Marcos-Gragera, R; Lopez, MDC; Ardanaz, E; Ibarluzea, J; Gomez-Acebo, I; Molina, AJ; O'Callaghan-Gordo, C; Aragones, N; Kogevinas, M; Pollan, M; Garcia-Perez, J

    Association between polyphenol intake and gastric cancer risk by anatomic and histologic subtypes: MCC-Spain

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    The study was partially funded by the “Accion Transversal del Cancer”, approved by the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI17CIII/00034) (...) Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036); by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the Fundación Caja de Ahorros de Asturias and by the University of Oviedo (...)Rubín-García, M., Vitelli-Storelli, F., José Molina, A., Zamora-Ros, R., Aragonés, N., Adarnaz, E., Castaño-Vinyals, G., Obón-Santacana, M., Gómez-Acebo, I., Molina-Barceló, A., Fernández-Tardón, G., Jiménez-Moleón, J.J., Alguacil, J., Dolores Chirlaque, M., Toledo, E., Pérez-Gómez, B., Pollán, M., Kogevinas, M., Martín, V

    Association between polyphenol intake and breast cancer risk by menopausal and hormone receptor status

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    The study was partially funded by the “Accion Transversal del Cancer", approved by the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI17CIII/00034), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)), by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-0306-2011, salud201200057018tra), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country, by the Consejería de Sanidad de la Región de Murcia, by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the Catalan Government- Agency for Management of University and Research Grants (AGAUR) grants 2017SGR723 and 2014SGR850, by the Fundación Caja de Ahorros de Asturias and by the University of Oviedo. and IDIBELL is aare members of the CERCA Programme, Generalitat de Catalunya. RZ-R was supported by the “Miguel Servet” program (CP15/00100) from the Institute of Health Carlos III (Co-funded by the European Social Fund (ESF)—ESF investing in your future).Vitelli-Storelli, F., Zamora-Ros, R., Molina, A.J., Fernández-Villa, T., Castelló, A., Barrio, J.P., Amiano, P., Ardanaz, E., Obón-Santacana, M., Gómez-Acebo, I., Fernández-Tardón, G., Molina-Barceló, A., Alguacil, J., Marcos-Gragera, R., Ruiz-Moreno, E., Pedraza, M., Gil, L., Guevara, M., Castaño-Vinyals, G., Dierssen-Sotos, T., Kogevinas, M., Aragonés, N., Martín, V

    Guidonia, la piazza comunale e i suoi edifici

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    Il contributo, nel ricostruire la vicenda storico costruttiva della città di fodnazione di Guidonia, affianca alla attività di ricerca storica, un articolato lavoro di rilievo delle caratteristiche metriche e costruttive degli edifici. Alcune esemplificazioni del risultato raggiunto nel grado di conoscenza dei caratteri costruttivi degli edifici è esemplificato con cinque schede relative agli edifici che circondano la piazza, redatte a cura dell'autore.The contribution in the reconstruction of the story of the historic city of constructive fodnazione Guidonia, alongside the activities of historical research, a detailed survey work of the metric characteristics and construction of buildings. Some examples of the results achieved in the degree of knowledge of the constructive character of the buildings is exemplified with five tabs on buildings surrounding the square, prepared by the author

    Polyphenol intake and gastric cancer risk: Findings from the stomach cancer pooling project (stop)

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    Phenolic compounds may exert a favorable effect on the risk of several cancer types, including gastric cancer (GC). However, selected polyphenol classes have not been adequately investigated in relation to GC. The aim of this study is to evaluate the association between the intake of polyphenols in relation to GC risk. We used data from the Stomach cancer Pooling (StoP) Project, including 10 studies from six countries (3471 GC cases and 8344 controls). We carried out an individual participant data pooled analysis using a two-stage approach. The summary odds ratios (ORs) of GC for each compound, and the corresponding 95% confidence intervals (95% CI), were computed by pooling study specific ORs obtained through multivariate logistic regression, using random effect models. Inverse associations with GC emerged for total polyphenols (OR = 0.67, 95% CI = 0.54–0.81, for the highest versus lowest quartile of intake), total flavonoids (OR = 0.73, 95% CI = 0.55–0.90), anthocyanidins (OR = 0.74, 95% CI = 0.56–0.92), flavanols (OR = 0.77, 95% CI = 0.66–0.88), flavanones (OR = 0.57, 95%CI = 0.44–0.69), total phenolic acids (OR = 0.75, 95%CI = 0.55–0.94), and hydroxybenzoic acids (OR = 0.73, 95%CI = 0.57–0.89). Results were consistent across strata of age, sex, social class, and smoking habit. Suggestive inverse associations were also found for flavonols (OR = 0.76, 95%CI = 0.51–1.01) and hydroxycinnamic acids (OR = 0.82, 95%CI = 0.58–1.06). Further investigations from longitudinal data are needed to confirm this association

    Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium

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    Although there is a clear relationship between family history (FH) and the risk of gastric cancer (GC), quantification is still needed in relation to different histological types and anatomical sites, and in strata of covariates. The objective was to analyze the risk of GC according to first-degree FH in a uniquely large epidemiological consortium of GC. This investigation includes 5946 cases and 12,776 controls from 17 studies of the Stomach Cancer Pooling (StoP) Project consortium. Summary odds ratios (OR) and the corresponding 95% confidence intervals (CIs) were calculated by pooling study-specific ORs using fixed-effect model meta-analysis techniques. Stratified analyses were carried out by sex, age, tumor location and histological type, smoking habit, socioeconomic status, alcohol intake and fruit consumption. The pooled OR for GC was 1.84 (95% CI: 1.64-2.04; I2 = 6.1%, P heterogeneity = 0.383) in subjects with vs. those without first-degree relatives with GC. No significant differences were observed among subgroups of sex, age, geographic area or study period. Associations tended to be stronger for non-cardia (OR = 1.82; 95% CI: 1.59-2.05 for subjects with FH) than for cardia GC (OR = 1.38; 95% CI: 0.98-1.77), and for the intestinal (OR = 1.92; 95% CI: 1.62-2.23) than for the diffuse histotype (OR = 1.62; 95% CI: 1.28-1.96). This analysis confirms the effect of FH on the risk of GC, reporting an approximately doubled risk, and provides further quantification of the risk of GC according to the subsite and histotype. Considering these findings, accounting for the presence of FH to carry out correct prevention and diagnosis measures is of the utmost importance
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