1,721,195 research outputs found
Multidrug-resistant Salmonella enterica serotype typhimurium infections [1] (multiple letters)
No full text5-FLUOROCITOSINA COME AGENTE ANTIBATTERICO
No full textLa presente invenzione concerne il farmaco antimicotico 5-fluorocitosina (anche detta
10 flucitosina ed abbreviata 5-FC) e la sua potente attività come antibatterico, in particolare la
sua attività anti-virulenza nei confronti di Pseudomonas aeruginos
H2O2 and {radical dot}NO scavenging by Mycobacterium leprae truncated hemoglobin O
No full textKinetics of ferric Mycobacterium leprae truncated hemoglobin O (trHbO-Fe(III)) oxidation by H2O2 and of trHbO-Fe(IV)=O reduction by (NO)-N-center dot and NO2- are reported. The value of the second-order rate constant for H2O2-mediated oxidation of trHbO-Fe(III) is 2.4 x 10(3) M-1 s(-1). The value of the second-order rate constant for (NO)-N-center dot-mediated reduction of trHbO-Fe(IV)=O is 7.8 x 10(6) M-1 s(-1). The value of the first-order rate constant for trHbO-Fe(III)-ONO decay to the resting form trHbO-Fe(III) is 2.1 x 10(6) s(-1). The value of the second-order rate constant for NO2--mediated reduction of trHbO-Fe(IV)=O is 3.1 x 10(3) M-1 s(-1). As a whole, trHbO-Fe(IV)=O, generated upon reaction with H2O2, catalyzes (NO)-N-center dot reduction to NO2-. In turn, (NO)-N-center dot and NO2- act as antioxidants of trHbO-Fe(IV)=O, which could be responsible for the oxidative damage of the mycobacterium. Therefore, Mycobacterium leprae trHbO could be involved in both H2O2 and (NO)-N-center dot scavenging, protecting from nitrosative and oxidative stress, and sustaining mycobacterial respiration. (C) 2008 Elsevier Inc. All rights reserved
Evaluation and optimization of anti-Chlamydophila pneumoniae IgG and IgA commercial ELISA assays in patients with coronary heart diseases
No full textH2O2 and {radical dot}NO scavenging by Mycobacterium leprae truncated hemoglobin O
No full textKinetics of ferric Mycobacterium leprae truncated hemoglobin O (trHbO{single bond}Fe(III)) oxidation by H2O2 and of trHbO{single bond}Fe(IV){double bond, long}O reduction by {radical dot}NO and NO2- are reported. The value of the second-order rate constant for H2O2-mediated oxidation of trHbO{single bond}Fe(III) is 2.4 × 103 M-1 s-1. The value of the second-order rate constant for {radical dot}NO-mediated reduction of trHbO{single bond}Fe(IV){double bond, long}O is 7.8 × 106 M-1 s-1. The value of the first-order rate constant for trHbO{single bond}Fe(III){single bond}ONO decay to the resting form trHbO{single bond}Fe(III) is 2.1 × 101 s-1. The value of the second-order rate constant for NO2--mediated reduction of trHbO{single bond}Fe(IV){double bond, long}O is 3.1 × 103 M-1 s-1. As a whole, trHbO{single bond}Fe(IV){double bond, long}O, generated upon reaction with H2O2, catalyzes {radical dot}NO reduction to NO2-. In turn, {radical dot}NO and NO2- act as antioxidants of trHbO{single bond}Fe(IV){double bond, long}O, which could be responsible for the oxidative damage of the mycobacterium. Therefore, Mycobacterium leprae trHbO could be involved in both H2O2 and {radical dot}NO scavenging, protecting from nitrosative and oxidative stress, and sustaining mycobacterial respiration. © 2008 Elsevier Inc. All rights reserved
Effect of siderophores and iron chelators on gallium inhibitory activity in Pseudomonas aeruginosa
No full textComposite integron array generated by insertion of an ORF341-type integron within a Tn21-like element
No full textTwo class 1 integrons, In-t1 and In-t2, were previously identified in IncFI plasmids of Salmonella enterica serotype Typhimurium. Molecular analysis revealed a close physical link between the two integrons. In-t1 is preceded by the transposase genes of Tn21, whereas In-t2 is located downstream the 3′-conserved segment (3′-CS) of In-t1, in a head-to-tail configuration. In-t1 shows a peculiar sequence downstream the 3′-CS, containing an extended version of the open reading frame known as ORF341 (referred to as ORF341E) and a novel trimethoprim resistance gene, designated dfrA18. Retrospective analysis provided evidence for In-t1 insertion within Tn1935, a Tn21-related transposon identified in IncFI plasmids circulating among epidemic clones of multidrug-resistant S. enterica during the 1970s. Structural comparison between Tn21 derivatives from recent and ancestor IncFI plasmids showed that In-t2 has been conserved by these replicons. In-t1 belongs to a novel family of class 1 integrons containing the ORF341E sequence, and appears to have been acquired by IncFI plasmids after the assembly of Tn1935. In-t insertion occurred within the 5′-conserved segment (5′-CS) proximal region of the resident In-t2
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