621 research outputs found

    Basic science and pathophysiology of ocular allergy

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    Ocular allergy includes several clinical subtypes ranging from the mild seasonal allergic conjunctivitis to the potentially sight-threatening atopic keratoconjunctivitis. Current therapies, particularly for the severe forms of disease, need to be more localized and with fewer side effects. For this to be achieved, it requires a better understanding of the basic mechanisms involved. In this chapter, recent findings are discussed that suggest that it is important to take an integrated approach, including both immune and structural elements of the eye. This provides potential new strategies for therapy, addressing the influence of structural cells in disease. These might influence the immune processes that take place and, as the structural cells are precisely localized, topical application is likely to be effective

    Keys to Virginia Invertebrates

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    Classification of algae -- Key to the free-swimming animals of jelly (less Hydromedusa) of Chesapeake Bay / H. Cones Key to some Virginia hydroids / D. Calder -- Key to sea anemones of Chesapeake Bay / M. Wass -- A key to the species of nemerteans of Virginia / W. McCaul -- Key to the polychaetes of Virginia ... / M. Wass, J. Melvin, and J. Kerwin -- Key to some marine gastropods of Virginia / J. Kraeuter -- Key to the pycnogonida of Virginia / J. McCain- Key to some groups of crustacea / J. Curtis -- Key to Virginia cumaceans / J. McCain -- A glossary of terms used in describing isopods, amphipods and decapods / J. Feeley -- Key to the isopoda and tanaidacea in marine waters of Virginia / J. McCain and D. Gibson -- Key to the amphipods of Virginia marine waters / J. McCain and J. Feeley -- Key to decapod crustaceans of the Chesapeake Bay area / M.L. Wass and J.M. Curtis -- Key to the echinoderms of Chesapeake Bay / J. Melvin -- Key to the chaetognatha of the inner continental shelf waters off Virginia / G.C. Grant.Virginia Institute of Marine Scienc

    CALDER: Cryogenic light detectors for background-free searches

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    CALDER is a R&D project for the development of cryogenic light detectors with an active surface of 5x5cm2 and an energy resolution of 20 eV RMS for visible and UV photons. These devices can enhance the sensitivity of next generation large mass bolometric detectors for rare event searches, providing an active background rejection method based on particle discrimination. A CALDER detector is composed by a large area Si absorber substrate with superconducting kinetic inductance detectors (KIDs) deposited on it. The substrate converts the incoming light into athermal phonons, that are then sensed by the KIDs. KID technology combine fabrication simplicity with natural attitude to frequency-domain multiplexing, making it an ideal candidate for a large scale bolometric experiments. We will give an overview of the CALDER project and show the performances obtained with prototype detectors both in terms of energy resolution and efficiency

    Who should be an author?

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    Maine Interview piece with Nigel Calder of Alna, author of the Boatowners\u27s M

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    Maine Interview piece with Nigel Calder of Alna, author of the Boatowners\u27s Mechanical and Electrical Manual, which has sold over 90,000 copies, and a number of other books, including The Cruising Guide to the Northwest Caribbean and Cuba: A Cruising Guide

    Adomo's physiognomical image of Mahler: the convergence of music, painting, and language

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    This study makes a case for the manifestation of mannerism in the music of Mahler through a close reading of Adomo's monograph on the composer, concurrently supporting the theory that mannerism is a distinct style, not limited to fixed periods, conditions in art, or media. The label 'Mannerism' connotes the style of sixteenth century Italian fine art, circumscribed by various art historians in the twentieth century. This study argues that the style is evident beyond the constraints of the sixteenth century, through the investigation of its manifestations in different artworks, created both in earlier and more contemporary times. The argument is constructed from a detailed comparison of the characteristics of the style in the paintings of sixteenth century Italian artists Arcimboldo and Parmigianino, the early twentieth century music by Schoenberg and Mahler, and Virginia Woolfs last novel. The comparison is facilitated by the utilisation of Barthes's writings on Arcimboldo, John Ashbery's poem about one of Parmigianino's paintings, and, predominantly, Adomo's interpretation of Mahler. The study also addresses issues that concern a comparison between different media, such as the problematical nature of the convergence of the arts. For example, the comparison of linguistic elements in both Arcimboldo's and Mahler's artworks is difficult to conduct without implying that art or music become language; the notion of a painterly language, or a musical language is complex and ambiguous. The study deals with the issue of whether one medium has to be fundamentally similar to another, in order to identify common characteristics between the two. In accordance with Adorno's writings on this paradigm, the conclusion drawn supports the position that the style of mannerism can be identified as manifesting itself in different mediums, without the necessity to scrutinise the fundamental connection between music, painting and literary forms

    Increasing transparency in the British Journal of Nutrition

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    Keen readers of the BJN will have noticed the recent appearance of ‘conflict of interest’ statements and of more complete descriptions of the contribution of each author to the publication. I have introduced these innovations in order to increase the transparency of the articles that we publish in the BJN; further strategies to increase accuracy, transparency and accountability of papers published in the journal will follow in order to encourage a climate of intellectual honesty and to decrease the risk of misconduct. In particular, the journal will follow as closely as possible the recommendations and guidelines of the Committee on Publishing Ethics (COPE)(1) and of the International Committee of Medical Journal Editors (ICMJE)(2). COPE and ICMJE have made available a range of guidelines aimed at establishing best practice in scientific publishing. These include guidelines for authors and for the conduct of reviewers, editorial boards and editors. Many of the guidelines are already followed by the BJN, but others are not yet fully in place

    Spatial Implications of Flood Exposure and Relocation Attitudes among Older Populations in Hampton Roads, VA

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    Coastal communities along the eastern seaboard are continuously exposed to flooding and related impacts, compromising the health and safety of their residents and especially of more vulnerable older populations. In cases where structural protection and floodproofing measures may not protect households from all types of flooding, relocation may represent the most effective long-term adaptation option. However, the extent to which older residents in Hampton Roads, Virginia are exposed to such flooding is not well understood, nor are the factors influencing their relocation attitudes. Thus, the main objective of this research is to understand both the exposure to flooding and evaluate attitudes towards relocation among older residents in Hampton Roads. This study uses a mixed methods approach to analyze flood exposure and attitudes towards relocation among older adults living in this area. First, a geospatial analysis was conducted to assess the change in flood risk in Hampton Roads over a period of 60 years and exposure to older populations, aged 60 and over. Then the survey data were used to conduct a correlation analysis to examine the relationship between survey responses and respondents' willingness to consider relocation. The geospatial analysis showed that flood exposure in this area does not increase linearly with time, with several block groups experiencing accelerated levels of flood increases from 2000-2060. Most of the municipalities which experience high overlap between flood extent and older population percentages are urban and see dramatic increases in flood exposure from 2000-2060. The statistical results show that willingness to consider relocation is correlated to several variables measuring sociodemographic characteristics, place attachment, and flood exposure, and less to other considerations influencing the decision to permanently relocate. The most influential factors driving relocation attitudes are financial, where residents would consider relocation if compensated or offered similar housing elsewhere. Finally, a large proportion of respondents (40.28%) would prefer to permanently move to either a different region or different state should flooding continue in their community. The results of this study can help community leaders and policymakers to better understand the flood outcomes and assistance needs of their older populations living in flood-prone areas.Master of ScienceCoastal communities along the Eastern United States are constantly exposed to flooding and related impacts. Hampton Roads, Virginia is experiencing higher-than-average sea level rise, which is increasing flooding and its impacts. This area is also a preferred retirement region, where older populations prefer to move. Older populations are more negatively affected by these impacts due to chronic health conditions like diabetes and hypertension, which require easy access to health care services, as well as mobility constraints. The objective of this research is to identify areas within Hampton Roads that have a significant overlap between flooding and older populations and to understand what factors are affecting older residents' attitudes towards relocation. This study answers the following questions regarding the overall objective: 1) What is the exposure to coastal flooding of older populations living in urban areas in Hampton Roads? and 2) Which aspects of socioeconomic circumstances, experiences with flooding, and flood-related concerns affect attitudes about permanent relocation among older coastal residents? To answer these questions, a geospatial analysis was conducted, followed by a survey analysis. There are high levels of overlap between older populations and flooding in urban municipalities, and flood exposure is expected to dramatically increase between the years 2000 and 2060. From the survey, older respondents favor monetary incentives for relocation as opposed to other factors. The results from this study should be used by local policymakers for more well-informed decisions that incorporate community members in the planning and relocation process
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