108 research outputs found
Jon Keune, Shared Devotion, Shared Food: Equality and the Bhakti-Caste Question in Western India [Ludovica Tozzi], p. 391
No full text"Shared Devotion, Shared Food: Equality and the Bhakti-Caste Question in Western India" by Jon Keune deals with an in-depth analysis of Marathi literature from 1854 to 1950, in order to find an answer to the question: "Can the idea that people are equal before God inspire them to treat each other as equals? Can theological egalitarianism lead to social equality?”. While trying to answer such a complex question, the author reveals the strengths and flaws of the so-called "most liberal Hindu religious movement"
Global, pathway and gene coverage of three Illumina arrays with respect to inflammatory and immune-related pathways
No full textGenome-wide association studies have led in the past to the discovery of susceptibility genes for many diseases including cancer and inflammatory conditions. However, a number of these studies did not realise their full potential. A first critical step in developing such large-scale studies is the choice of genotyping array with respect to the study goal. Coverage is the central criterion for array evaluation. We distinguish between estimates of global coverage across the genome, coverage for each chromosome, coverage for selected pathways and the coverage for genes of interest. Here, we focus on inflammatory and immunological pathways and genes relevant for haematopoietic stem cell transplantation. We compared three arrays: the Infinium Global Screening Array-24 v1.0, the Infinium OncoArray-500 K BeadChip and the Infinium PsychArray-24 v1.2 BeadChip. We employed the European population from the 1000 Genomes Project as reference genome. Global coverage was found to range between 12.2 and 14.2% whereas coverage for a selected pathway ranged from 6.2 to 13.2% and gene coverage ranged from 0 to 54.1%. The Global Screening Array outperformed both other arrays in terms of global coverage, for most chromosomes, most considered pathways and most genes. When selecting suitable arrays for a new study, the coverage of pathways or genes of interest should be considered in addition to global coverage. Local coverage should be regarded when discussing association findings inconsistent across studies and can be useful in data analysis and decision making for additional genotyping
Dentro «Il podere» di Federigo Tozzi: la 'tecnica del montaggio'
No full textThis article analyses a particular assembly technique used by Federigo Tozzi in composing his texts. The case of study is offered by one of his major novels, «Il podere» (1921), whose manuscript reveals how Tozzi deliberatly left some descriptives parts to be completed later. To reach this completion, the author could work en plein air, to catch a landscape as a painter would have done, otherwise re-use some pages written years before. In this second case, the pages here re-used are taken from the typescript of «Adele» (1979, posthumous), the well-known first novel never published by Tozzi but rather dis-mantled, put aside and kept in a drawer as a sort of tank of useful pages, to be re-used if necessary
On characterization of (E,M)-structures in procategories,
No full textMardesic introduced the concept of pro-reflective (dense) subcategory of a category C in order to define a categorical shape theory for topological spaces. Following the results obtained by the author introducing the (E,M)-factorisation structure on C w.r.t ProC, it is given a characterisation of those classes M for which there exists the class E in the ProC morphisms such that the pair (E,M) is a factorisation structure on C w.r.t. Pro
ImputAccur: fast and user-friendly calculation of genotype-imputation accuracy-measures
No full textBACKGROUND: ImputAccur is a software tool to measure genotype-imputation accuracy. Imputation of untyped markers is a standard approach in genome-wide association studies to close the gap between directly genotyped and other known DNA variants. However, high accuracy for imputed genotypes is fundamental. Several accuracy measures have been proposed, but unfortunately, they are implemented on different platforms, which is impractical. RESULTS: With ImputAccur, the accuracy measures info, Iam-hiQ and r(2)-based indices can be derived from standard output files of imputation software. Sample/probe and marker filtering is possible. This allows e.g. accurate marker filtering ahead of data analysis. CONCLUSIONS: The source code (Python version 3.9.4), a standalone executive file, and example data for ImputAccur are freely available at https://gitlab.gwdg.de/kolja.thormann1/imputationquality.git. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12859-022-04863-z
Tracing the evolution in the iron content of the intra-cluster medium
No full textContext. We present a Chandra analysis of the X-ray spectra of 56 clusters of galaxies at z greater than or similar to 0.3, which cover a temperature range of 3 less than or similar to kT less than or similar to 15 keV. Aims. Our analysis is aimed at measuring the iron abundance in the intra-cluster medium (ICM) out to the highest redshift probed to date. Methods. We made use of combined spectral analysis performed over five redshift bins at 0.3 less than or similar to z less than or similar to 1.3 to estimate the average emission weighted iron abundance. We applied non-parametric statistics to assess correlations between temperature, metallicity, and redshift. Results. We find that the emission-weighted iron abundance measured within (0.15-0.3) R-vir in clusters below 5 keV is, on average, a factor of similar to 2 higher than in hotter clusters, following Z(T) similar or equal to 0.88 T-0.47 Z(circle dot), which confirms the trend seen in local samples. We also find a constant average iron abundance Z(Fe) similar or equal to 0.25 Z(circle dot) as a function of redshift, but only for clusters at z greater than or similar to 0.5. The emission-weighted iron abundance is significantly higher (Z(Fe) similar or equal to 0.4 Z(circle dot)) in the redshift range z similar or equal to 0.3-0.5, approaching the value measured locally in the inner 0.15 R-vir radii for a mix of cool-core and non cool-core clusters in the redshift range 0.1 less than or similar to z less than or similar to 0.3. The decrease in metallicity with redshift can be parametrized by a power law of the form similar to(1 + z)(-1.25). We tested our results against selection effects and the possible evolution in the occurrence of metallicity and temperature gradients in our sample, and we do not find any evidence of a significant bias associated to these effects. Conclusions. The observed evolution implies that the average iron content of the ICM at the present epoch is a factor of similar to 2 larger than at z similar or equal to 1.2. We confirm that the ICM is already significantly enriched (ZFe similar or equal to 0.25 Z(circle dot)) at a look-back time of 9 Gyr. Our data provide significant constraints on the time scales and physical processes that drive the chemical enrichment of the ICM
L’infante, la donna, la bestia: un’analisi ecocritica degli incontri non umani in Federigo Tozzi, Dino Buzzati, Anna Maria Ortese
No full textRestricted AccessThe authorial connections between Federigo Tozzi, Dino Buzzati and Anna Maria Ortese are notable and varied. Linked by a fervent animalistic and, in the case of the latter two, also environmentalist spirit, the non-human plays a central role in the works of the authors, who represent natural entities, animals, or fantastic creatures as narrative archetypes of universal pain. This thesis investigates the encounters between the human and the nonhuman in the works of Tozzi, Buzzati, and Ortese with the aim of answering the questions “what does otherness represent for the authors?”, and “how is this 'other' portrayed in their novels, short stories, and journalistic writings?”. To tackle these issues, my analysis considers three thematic areas, namely the representation of the child, the woman, and the beast, categories united by a perception of inferiority, and thus of marginalization, in a purely patriarchal social context. In the three chapters, one per individual author, the investigation of the three principal thematic areas makes use of a range of critical theories such as Ecocriticism (Garrard, Buell, Wolfe, Iovino), Animal Studies (Derrida, Cimatti, Regan, Singer), Ecofeminism (Warren, Adams, Plumwood, Ruether) and Children's Studies (Freud, Joosen, Khan, Kellert).
In the works of the three authors, the animal is portrayed as abused, castrated, and killed, and this confirms how, due to a lack of logos, the nonhuman can be easily subjugated in human society. On other occasions, the animal, as a model of otherness, is acknowledged by the authors as a fragile entity, and thus in need of protection or defense. However, animality also serves the function of representing human figures through animalistic characteristics, or portraying characters who are placed on the same social scale as beasts enslaved to man: namely, women and children.
Therefore, after having traced the narrative archetypes and symbolic connections between the child, the woman, and the animal in selected works of Tozzi, Buzzati and Ortese, the last part of the respective chapters addresses the salient themes of the three authors' attitude towards animals from an ethical-moral perspective. In the case of Tozzi, I analyze texts that draw upon his strong influence by nonhuman agents. For Ortese and Buzzati, I consider a selection of the authors’ militant journalistic production which advocates for the protection of those who have no voice to denounce their own oppression, existential imperatives of an ethical-moral order which constitute the critical building blocks of their animalist spirit. The conclusions highlight the connections between the authors through the three thematic cores examined (child, woman, and beast), and trace the positioning of the nonhuman in the authorial imaginary of Tozzi, Buzzati and Ortese, authors who are only seemingly dissimilar, but who are linked, instead, by a profound, indissoluble interest in the other
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