17 research outputs found
Acute pulmonary edema after laryngospasm.
No full textPulmonary edema may develop in healthy patients after anesthesia. Even in adult patients it is important to ascertain the depth of anesthesia before extubation. Too early extubation can result in laryngospasm, followed by increased inspiratory effort and significant rises in pulmonary capillary pressure, which may create fluid movements in the lung resulting in pulmonary edema.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Is Intrathecal lidocaine administration risk‐free in rats with neuropathic pain? Reply to [Effects of intrathecal lidocaine on hyperalgesia and allodynia following chronic constriction injury in rats. Eur J Pain 13 (2009) 130–137]
No full textLiposomal bupivacaine controlled release applied to human pharmacokinetics
No full textSCOPUS: cp.jinfo:eu-repo/semantics/publishe
99mTechnetium-stannous oxinate as marker of liposome formulations
No full textLiposomes associated with tin(II) dioxinate were prepared from egg yolk phosphatidylcholine and cholesterol as sterile and pyrogen-free multilamellar or unilamellar vesicles. Complexing of liposomal tin(II) dioxinate with 99mTc attained 98% of the added radioactivity. Thirty percent 99mTc were released during 24-h incubation in biological fluids. The absence of tin colloids seen by electron microscopy and the stability of liposomal phospholipid and tin(II) dioxinate during 72-h incubation at 37°C in plasma and cerebrospinal fluid would allow safe and reliable scintigraphic liposome pharmacokinetic studies.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Effects of carbon dioxide embolism with nitrous oxide in the inspired gas in piglets
No full textSCOPUS: ar.jinfo:eu-repo/semantics/publishe
Distribution of 99m TC unilamellar liposomes in the subarachnoidal space of rats
No full textSCOPUS: cp.jinfo:eu-repo/semantics/publishe
Esophageal Findings in the Setting of a Novel Preventive Strategy to Avoid Thermal Lesions during Hybrid Thoracoscopic Radiofrequency Ablation for Atrial Fibrillation
No full textPurpose The development of an atrio-esophageal fistula, a rare yet potentially lethal complication of ablation for atrial fibrillation, could be related to direct tissue heat transfer during and immediately after the ablation. We therefore studied the postoperative esophageal findings by esophagogastroduodenoscopy in patients that underwent a hybrid ablation procedure using a novel preventive strategy to avoid thermal lesions. Methods Thirty-four patients (28 males; 65 years ± 9 years) were retrospectively included. All underwent a hybrid ablation in our center between April 2015 and November 2019 and agreed to an esophagogastroduodenoscopy within 0–14 days (mean: 5 days) following the ablation. To reduce the incidence of thermal lesions three procedural preventive strategies were introduced: (i) videoscopic intrathoracic transesophageal echocardiographic probe visualization to understand the relationship between posterior left atrial wall and esophagus, with probe retraction before ablation; (ii) lifting the cardiac tissue away from the esophagus during energy application; and (iii) a 30-s cool-off period after energy delivery with irrigation of the device, the ablated tissue, and the surrounding tissues. Results No esophageal thermal lesions were observed. One third of patients were diagnosed with incidental esophageal findings unrelated to the ablation procedure (11; 32.4%). Conclusion Novel preventive strategies by visualization and by avoiding contact between the ablation catheter or ablated tissue and the pericardium, seems to eliminate the potential risk of esophageal thermal lesions in the setting of hybrid ablation. Since one third of patients had preexisting esophageal disease, a more comprehensive pre-operative screening could be important to reduce the risk
One-stage Approach for Hybrid Atrial Fibrillation Treatment
No full textThe one-stage approach for hybrid atrial fibrillation involves the simultaneous and close cooperation of different medical specialties. This review attempts to describe its challenging issues, exposing a plan to balance thrombotic risk and bleeding risk. It describes the combined surgical-electrophysiological procedure. Specific topics, involving hemodynamic, fluid and respiratory management during surgery are considered, and problems related to postoperative pain are surveyed.</jats:p
Biodistribution of liposomes after extradural administration in rodents
No full textWe have mapped over 24 h the biodistribution of 99mTc-labelled multilamellar and small unilamellar liposomes in rabbits and rats by scintigraphic imaging after extradural injection. Multilamellar vesicles formed a depot at the site of injection; small unilamellar vesicles spread immediately along the extradural space and entered the systemic compartment 30 min after injection. Well-delineated liver and kidney labellings were seen after 24 h. The use of 3H-cholesterol-labelled small unilamellar vesicles suggested hepatic capture of intact liposomes with sizes averaging 0.05μm drained unmodified into the systemic circulation through the extradural lymphatics. These results have led to the selection of multilamellar vesicles (0.1-15μm size range) for clinical trials using liposome-associated local anaesthetics.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
