1,720,972 research outputs found
MeCP2 aberrant functionality interacts with sex in shaping stress effects on cognitive functions
No full text
Chronic treatment with the phytocannabinoid cannabidivarin (CBDV) rescues behavioural alterations and brain atrophy in a mouse model of rett syndrome
No full textRett syndrome (RTT) is a rare neurodevelopmental disorder, characterized by severe behavioural and physiological symptoms. RTT is caused by mutations in the MECP2 gene in about 95% of cases and to date no cure is available. The endocannabinoid system modulates several physiological processes and behavioural responses that are impaired in RTT and its deregulation has been associated with neuropsychiatric disorders which have symptoms in common with RTT. The present study evaluated the potential therapeutic efficacy for RTT of cannabidivarin (CBDV), a non-psychotropic phytocannabinoid from Cannabis sativa that presents antagonistic properties on the G protein-coupled receptor 55 (GPR55), the most recently identified cannabinoid receptor. Present results demonstrate that systemic treatment with CBDV (2, 20, 100 mg/Kg ip for 14 days) rescues behavioural and brain alterations in MeCP2-308 male mice, a validated RTT model. The CBDV treatment restored the compromised general health status, the sociability and the brain weight in RTT mice. A partial restoration of motor coordination was also observed. Moreover, increased levels of GPR55 were found in RTT mouse hippocampus, suggesting this G protein-coupled receptor as new potential target for the treatment of this disorder. Present findings highlight for the first time for RTT the translational relevance of CBDV, an innovative therapeutic agent that is under active investigation in the clinical setting
Trauma-exposed methyl-CpG binding protein 2 mutant mice: a new animal model for post-traumatic stress disorder
No full textThe phytocannabinoid cannabidivarin (CBDV) rescues behavioural alterations and brainatrophy in Mecp2-308 hemizygous male mice
No full textPharmacological stimulation of 5-HT7 receptor rescues Sensory-motor gating and emotional memory-associative learning function in MeCP2-308 female mice.
No full textRett syndrome before regression: a time window of overlooked opportunities for diagnosis and intervention
No full textRett syndrome (RTT) is a rare neurological disorder primarily affecting females, causing severe cognitive, social, motor and physiological impairments for which no cure currently exists. RTT clinical diagnosis is based on the peculiar progression of the disease, since patients show an apparently normal initial development with a subsequent sudden regression at around 2 years of age. Accumulating evidences are rising doubts regarding the absence of early impairments, hence questioning the concept of regression. We reviewed the published literature addressing the pre-symptomatic stage of the disease in both patients and animal models with a particular focus on behavioral, physiological and brain abnormalities. The emerging picture delineates subtle, but reliable impairments that precede the onset of overt symptoms whose bases are likely set up already during embryogenesis. Some of the outlined alterations appear transient, suggesting compensatory mechanisms to occur in the course of development. There is urgent need for more systematic developmental analyses able to detect early pathological markers to be used as diagnostic tools and precocious targets of time-specific interventions
Methyl-CpG binding protein 2 (MeCP2) dysfunction provides vulnerability to traumatic events in male mice
No full textBehavioural alterations and brain atrophy are rescued by chronic treatment with the phytocannabinoid, Cannabidivarin (CBDV), in a mouse model of Rett syndrome
No full text- …
