2,320 research outputs found
Portrait of Sir K. H. Bailey, [ca. 1925] [picture].
No full textCondition: Good.; Two copies of the same photograph.; Title from inscription on lower left corner and on reverse.; Inscriptions: 1. "K.H.B. c 1925" --In ink on lower left corner. 2. "K.H. Bailey [Victoria 1918]" --In ink on reverse.; Related material: Sir Kenneth Bailey papers National Library of Australia Manuscripts section MS 4622; Related material: Personal photograph albums of Sir Kenneth Bailey National Library of Australia Pictorial section PIC/P776 Albums 665, 863, 976. Part of a collection of portraits and photographs relating to Sir Kenneth Bailey, his family and career
Covers for S-acts and condition (A) for a monoid S
No full textA monoid S satisfies Condition (A) if every locally cyclic left S-act is cyclic. This condition first arose in Isbell’s work on left perfect monoids, that is, monoids such that every left S-act has a projective cover. Isbell showed that S is left perfect if and only if every cyclic left S-act has a projective cover and Condition (A) holds. Fountain built on Isbell’s work to show that S is left perfect if and only if it satisfies Condition (A) together with the descending chain condition on principal right ideals, MR. We note that a ring is left perfect (with an analogous definition) if and only if it satisfies MR. The appearance of Condition (A) in this context is therefore monoid specific.Condition (A) has a number of alternative characterisations, in particular, it is equivalent to the ascending chain condition on cyclic subacts of any left S-act. In spite of this, it remains somewhat esoteric. The first aim of this article is to investigate the preservation of Condition (A) under basic semigroup-theoretic constructions.Recently, Khosravi, Ershad and Sedaghatjoo have shown that every left S-act has a strongly flat or Condition (P) cover if and only if every cyclic left S-act has such a cover and Condition (A) holds. Here we find a range of classes of S-acts C such that every left S-act has a cover from C if and only if every cyclic left S-act does and Condition (A) holds. In doing so we find a further characterisation of Condition (A) purely in terms of the existence of covers of a certain kind.Finally, we make some observations concerning left perfect monoids and investigate a class of monoids close to being left perfect, which we name left IPa-perfect
7-deaza-8-bromo-cyclic ADP-ribose, the first membrane-permeant, hydrolysis-resistant cyclic ADP-ribose antagonist
No full textCyclic ADP-ribose (cADPR) is a putative second messenger that has been demonstrated to mobilize Ca2+ in many cell types. Its postulated role as the endogenous regulator of ryanodine-sensitive Ca2+ release channels has been greatly supported by the advent and use of specific cADPR receptor antagonists such as 8-NH2-cADPR (Walseth, T. F., and Lee, H. C. (1993) Biochim. Biophys. Acta 1178, 235-242). However, investigations of the role of cADPR in physiological responses, such as fertilization, stimulus-secretion coupling, and excitation-contraction coupling, have been hindered by the susceptibility of cADPR receptor antagonists to hydrolysis and the need to introduce these molecules into cells by microinjection or patch clamp techniques. We have recently reported on the discovery of a poorly hydrolyzable analogue of cADPR, 7-deaza-cADPR (Bailey, V. C., Sethi, J. K., Fortt, S. M., Galione, A., and Potter, B. V. L. (1997) Chem. Biol. 4, 41-51) but this, like cADPR, is an agonist of ryanodine-sensitive Ca2+ release channels. We therefore explored the possibility of combining antagonistic activity with that of hydrolytic resistance and now report on the biological properties of the first hydrolysis-resistant cADPR receptor antagonist, 7- deaza-8-bromo-cADPR. In addition this compound has the advantage of being membrane-permeable. Together these properties make this hybrid molecule the most powerful tool to date for studying cADPR-mediated Ca2+ signaling in intact cells.</p
Landscapes of violence: women surviving family violence in regional and rural Victoria
No full textIn this research, family violence survivors have identified issues and barriers they have encountered, and have provided suggestions in regards to how both the criminal justice system and the broader Victorian community might assist survivors and help prevent family violence.
Overview
This project combines the findings of two studies undertaken by the Centre for Rural and Regional Law and Justice. Drawing on and extending the findings in Women\u27s experience of surviving family violence and accessing the Magistrate\u27s court in Geelong, Victoria (2013), this report extends the research in terms of geographic areas, issues covered and range of participants.
It examines the experiences of, and outcomes for, women survivors of family violence in regional and rural Victoria, considering their contact with, and perceptions of, government agencies (including Victoria Police, the Victorian Magistrate\u27s courts and the Department of Human Services) as well as private and community advocates (legal services, women\u27s services and family violence services) and healthcare professionals.
Through this research, survivors have identified issues and barriers they have encountered in escaping family violence, and have provided suggestions in regards to how both the criminal justice system and the broader Victorian community might assist survivors and help prevent family violence. As well as being informed by survivors, this publication includes insights provided by government and non-government practitioners and organisations who have offered their views on this report\u27s key findings and recommendations. In addition to the generous contributions of these participants, this report utilises relevant data and emerging research in an effort to identify best practice responses to family violence; improve access to justice, support and safety; and protect and promote women\u27s rights and entitlements
7-Deaza cyclic adenosine 5′-diphosphate ribose: first example of a Ca2+-mobilizing partial agonist related to cyclic adenosine 5′-diphosphate ribose
No full textBackground: Cyclic adenosine 5′-diphosphate ribose (cADPR), a naturally occurring metabolite of nicotinamide adenine dinucleotide (NAD+), mobilizes Ca2+ from non-mitochondria' stores in a variety of mammalian and invertebrate tissues. It has been shown that cADPR activates ryanodine-sensitive Ca2+-release channels, working independently of inositol 1,4,5-trisphosphate (IP3) to mobilize intracellular Ca2+ stores. In some systems, cADPR has been shown to be more potent than IP3. The chemo-enzymatic synthesis of structurally modified analogues of cADPR can provide pharmacological tools for probing this new Ca2+-signaling pathway. In this work, we describe the synthesis and evaluation of a structural mimic of cADPR with different Ca2+-releasing properties.Results: 7-Deaza cyclic adenosine 5′-diphosphate ribose (7-deaza cADPR), a novel cADPR analogue modified in the purine ring, was synthesized and its ability to release Ca2+ from non-mitochondria' pools in homogenates made from sea urchin eggs was investigated. 7-Deaza cADPR was more effective in releasing Ca2+ than cADPR, but it only released approximately 66% of the Ca2+ released by a maximal concentration of cADPR. It was also more resistant to hydrolysis than cADPR. If we administered increasing concentrations of 7-deaza cADPR at the same time as a maximal concentration of cADPR, the induction of Ca2+ release by cADPR was antagonized.Conclusions: 7-Deaza cADPR has a Ca2+-release profile consistent with that of a partial agonist, and it is the first reported example of such a compound to act at the cADPR receptor. The imidazole ring of cADPR is clearly important in stimulating the Ca2+-release machinery, and the present results demonstrate that structural modification of a site other than position 8 of the purine ring can affect the efficacy of Ca2+ release. 7-Deaza cADPR represents a significant step forwards in designing modulators of the cADPR signaling pathway
Synthesis of 7-deaza-8-bromo cyclic adenosine 5′-diphosphate ribose: The first hydrolysis resistant antagonist at the cADPR receptor
No full text7-Deaza-8-bromo cyclic adenosine 5′-diphosphate ribose is synthesised from 7-deazaadenosine via 7-deaza-8-bromo nicotinamide adenine dinucleotide; it is both a more potent antagonist than the 8-bromo derivative and has the advantage of chemical and enzymatic hydrolytic stability.</p
Book Review: Men of God, Men of War: Military Chaplains as Ministers, Warriors, and Prisoners
No full textAuthor: Robert C. Doyle
Reviewed by: Chaplain (Colonel) Geoff Bailey, PhD, US Army War College chaplain and director of ethical development, Department of Command, Leadership, and Management, US Army War College
Robert C. Doyle offers a sweeping historical study of chaplains in American wars, revealing how faith and duty intersected on battlefields and in prison camps.https://press.armywarcollege.edu/parameters_bookshelf/1104/thumbnail.jp
Secondary Schools in the New Zealand Social Order, 1840-1903
No full textThe New Zealand pioneer, like the North American frontiersman, has become to many New Zealanders a romanticized symbol rather than a real person struggling to adapt to a strange and often frightening environment. 'As ye sow so shall ye reap' was for the pioneer farmer an injunction to be taken literally. After exhausting his resources in buying his small-holding the pioneer farmer 'would start on foot and alone...with a heavy swag of tools etc, on his back, to which, on passing the last older settler, would be added the additional burden of a kit of seed potatoes and some rations. With these he would camp down on his future lowly home and would work hard, for long hours on very scanty fare...to hurry in a patch of potatoes, and to make a pig-proof fence round it. He would then beat a retreat to the more settled districts, where he would seek employment until his little crop of potatoes was grown when he would return with a heavier load of rations...and this time he would be able to put in a larger crop and to build a whare, so that the next season he might have the joy of conveying his family to the scene of their future expectations. But it was hand work, and there were many privations to undergo for the first few years....
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Statement by Dr. Kathleen C. Bailey before the Senate Armed Services Committee
No full textThis paper presents the personal views of the author on the subject of the proposed Chemical Weapons Convention (CWC). She addresses here concerns about the national security issues which could result from ratification of this convention. She argues the convention alone is not likely to curtail production or availability of such items on the world market because of the relatively low cost. The treaty could thus put the country in a position less likely to protect itself, or adequately deal with such a threat
Laboratory culture of the free-living stages of Neomesomermis flumenalis, a mermithid nematode parasite of Newfoundland blackflies (Diptera: Simuliidae)
No full textLaboratory methods were developed for culturing the free-living stages of Neomesomermis flumenalis, a mermithid parasite of simuliids, especially Simulium venustum Say and the complex of Prosimulium mixtum Syme & Davies and P. fuscum Syme & Davies, from simuliid larvae collected in the field in Newfoundland. The best results were obtained by placing 50 pairs of nematodes under xenic conditions in 500-ml containers containing about 450 ml wet sand. With this method, 78.6% of the females introduced to culture reproduced. The influence of factors such as microorganisms, substrate, container volume and sterility on culturing the mermithid is discussed. Differences were noted in the development of N. flumenalis from winter-breeding Prosimulium hosts and those from summer-breeding Simulium. Parasites from Simulium developed nearly twice as fast as those from Prosimulium at 10 deg C. Studies showed that Simulium parasites were better adapted for higher temperatures (20 deg C) but were more poorly adapted to lower ones (5 deg C) than parasites from Prosimulium. The differences noted suggest that there are two physiological strains of the same species, one developing in Simulium spp. and the other in Prosimulium spp..RE: 13 ref.; MS: 2 fig.; SC: ZA; HE; CA; PE; PA; VE; 0J; 0H; 0TSource type: Electronic(1
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