1,721,382 research outputs found
Tea in health and disease prevention/ Edit.: Victor R. Preedy
No full text1573 hal.: ill, tab.; 29 cm
Tea in health and disease prevention/ Edit.: Victor R. Preedy
No full text1573 hal.: ill, tab.; 29 cm
Contribution to the “Comprehensive Handbook of Iodine: Nutritional, Biochemical, Pathological and Therapeutic Aspects”
No full textThis item is Basil Hetzel’s “Iodine Deficiency and the Brain” chapter contribution to “Comprehensive Handbook of Iodine: Nutritional, Biochemical, Pathological and Therapeutic Aspects” edited by Victor R. Preedy, Gerard N. Burrow, Ronald Ross Watson.
Contribution to the “Comprehensive Handbook of Iodine: Nutritional, Biochemical, Pathological and Therapeutic Aspects”
No full textThis item is Basil Hetzel’s "The Role of the ICCIDD in the Global Program for the Elimination of Brain Damage due to Iodine Deficiency" chapter contribution to “Comprehensive Handbook of Iodine: Nutritional, Biochemical, Pathological and Therapeutic Aspects” edited by Victor R. Preedy, Gerard N. Burrow, Ronald Ross Watson.
Features and measures of depression in the elderly and the impact of the COVID-19 pandemic: Linking in preexisting mental health
No full textHandbook of disease burdens and quality of life measures/ Edit.: Victor R. Preedy
No full textlx, p. 782: ill.: tab.; 27 c
Antioxidant Supplementation in Health Promotion and Modulation of Aging: An Overview
No full textAntioxidants have become a necessity as a consequence of adaptation to life under aerobic conditions. Oxygen (or dioxygen, triplet O2) is strictly necessary for our energetic metabolism; however the oxidizing activity of oxygen (or its derivatives) sometimes goes out of control and results in so-called oxidative stress, which can lead to biological
damage if not balanced by antioxidant defenses. The processes leading to oxidative damage and the role of dietary antioxidants are overviewed focusing on the potential of dietary antioxidants in preventing aging-related disease
High-fat diet Influences on Sleep Regulation: Lessons From Animal Studies
No full textThe interaction between a high-fat diet (HFD) and sleep regulation takes place against the common background of metabolism, at a hypothalamic level. Typical sleep modifications observed in laboratory rodents kept under an HFD regimen, compared to normal fed controls, are: a lower daily amount of wakefulness mirrored by a higher amount of non-REM sleep that is also more fragmented and of a worse quality. REM sleep amount is mildly augmented in HFD-fed animals. The circadian distribution of the wake-sleep cycle is also modified and HFD also interferes with clock gene regulation. The opposite interaction is also true: prolonged sleep modifications may alter feeding behavior. These complex interactions involve different hypothalamic structures, but among these, the orexinergic system of the lateral hypothalamus may have a primary role. Animal models help to shed light on these processes, possibly suggesting more efficient approaches that can be considered in the treatment and prevention of obesity and metabolic syndromes
Recommended resources for oxidative stress and dietary antioxidants in neurological diseases
No full textNeurological diseases impose substantial socioeconomic burden on the society. These diseases are characterized by damage to specific populations of cells within specific areas of the nervous system. The extremely high metabolic demands of neuronal tissue result in high oxygen consumption and energy production. Neurological tissue is particularly high risk of oxidative damage from reactive oxygen species. As a result, oxidative stress has implicated in the pathogenesis of several neurodegenerative diseases including Alzheimer's and Parkinson’s. Antioxidant compounds that inhibit oxidation are required to prevent oxidative damage in vivo. Oxidative stress reflects an imbalance between the systemic manifestation of ROS and the ability to detoxify the ROS or repair the resulting damage. In the 1920s and 1930s, the isolation of vitamins C and E and their identification as dietary antioxidants revolutionized the field. Since then the knowledge and understanding of oxidative stress and antioxidants has increased exponentially. It is now difficult even for experienced scientists to remain up to date. To assist colleagues who are interested in understanding more about this field, we have, therefore, produced tables containing up-to-date resources on the regulatory and professional bodies, journals, books, and websites that are relevant to the study of oxidative stress and dietary antioxidants in neurological disease
Linking endocannabinoid system, palmitoylethanolamide, and sarcopenia in view of therapeutic implications
No full textSarcopenia, a debilitating skeletal muscle disease closely connected with elderly, is becoming a major public health problem with the increasing of life expectancy. In the aim to found effective, targeted and side-effect-free therapies, understanding the endocannabinoid system (ECS) role in muscle homeostasis is of strategic importance. The skeletal muscle expresses all the ECS elements; in particular, a central role is played by the nuclear receptor PPARα and its main endogenous ligand, palmitoylethanolamide (PEA), an endocannabinoid-like molecule with an important anti-inflammatory effect. It is worth highlighting that in muscle the expression level of both PPARα receptor and its coactivator PGC1a, decreases with age, suggesting a causative relation between the lower PPARα function and sarcopenia. Therefore, the administration of PEA to the muscle can be a promising approach to counteract sarcopenia. In this regard, to promote the muscle targeting, innovative drug delivery systems, such as solid lipid nanoparticles, can be considered
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