4,706 research outputs found
The sense of a beginning : Bakhtinian dialogic criticism on 'the gospel' in Mark.
No full textContemporary literary approaches have caused paradigm shifts in Biblical Studies in the last two decades as it appears in a great deal of Markan studies using narrative, reader-response, deconstructive, feminist, and new historicist approaches. However, literary studies on the Gospel of Mark have not taken into account theoretical questions underlying those approaches. As a result biblical critics are driven by new trends without ever having a chance to examine the critical baggage of the approaches. Consequently, there is a gap of communication between the old and the new one. Therefore this thesis is an attempt to meet the need of enhancing the quality of critical endeavour in biblical studies. In the light of most recent competing critical theories of literature, the first contribution of this thesis is the methodological finding that Bakhtinian dialogic criticism contains the most profound philosophical and practical foundations for solving some crucial theoretical problems in contemporary literary theories. It is a critique to a Saussurian linguistic system of language which becomes the very foundation of modern and postmodern literary criticism. Bakhtinian literary theory shifts the foundation of literary criticism on linguistic signs into the creative activity of the socio-cultural production of human communication. The shift into socio-cultural reality of language communication makes the notion of 'genre' very important to unlock the problem of text and context in literary studies. Since the Gospel of Mark has fascinated most literary critics in Biblical Studies, the problem of 'genre' of this gospel is chosen as the focus of this study. Secondly, as no agreement is reached as to what 'genre' the Gospel of Mark belongs, this thesis makes its contribution to the discussion by locating the problem of 'genre' of Mark in the context of genre theories and argues that the Bakhtinian suggestion to find genre in the socio-cultural sphere by analysing artistic intercourse between narrative agents in Mark has freed the competing analysis from the unresolved problem between the kerygmatic (content oriented) approach and the analogical (form oriented) approach. To achieve finding 'genre' in the socio-cultural sphere, this thesis focuses on Bakhtinian analysis of the process of artistic intercourse between narrative agents. The narrative communicative interrelationships between narrative agents is constructed in this thesis as a 'stereophonic' Bakhtinian model of dialogic communication. This model is an original contribution of this thesis for revising the traditional two dimensional model of narrative communication. Based on this dialogical model of communication, a special role is given to the Bakhtinian 'author-creator' in the realization process of genre through the interaction of polyphonic voices. Through the interaction of voices of the author-artist and the hero we are led to discover a relatively stable type of portraying and controlling reality in Mark, known as the genre of Roman 'satire'. The closest literary affinity is Satyrica by Petronius. This narrative strategy of 'satire' in Mark has its root in the prophetic discourse of the Old Testament which is saturating the speech of the narrator, John the Immerser, the centurion, the people, and even Jesus. Finally, the whole search for Markan 'genre' culminates in the analysis of the realization of genre through the analysis of Bakhtinian chronotope. The reality of the genre of Mark is its social reality that is in its role as dpxrj/ 'beginning'. As the Gospel of Mark proclaims itself as 'a beginning', it defines its claim of socio-cultural 'authority' in early Christianity. It is this 'sense of beginning' which enables the narrating and the narrated world of Mark to interact dialogically
Maternal undernutrition leads to endothelial dysfunction in adult male rat offspring independent of postnatal diet
No full textIncreasing evidence suggests a role for prenatal environment in the onset of cardiovascular and metabolic disease in later life. In the rat, undernutrition in utero and a postnatal high-fat diet gives rise to a phenotype similar to the metabolic syndrome. As endothelial dysfunction is a feature of both CVD and the metabolic syndrome we investigated the impact of maternal undernutrition and/or postnatal high-fat on endothelial function. Virgin Wistar rats were mated and randomly assigned to groups to receive food either ad libitum (control) or at 30 % of ad libitum intake throughout gestation. At postnatal day 250, a cohort from each group was challenged with a high-fat diet (D12451, 45 % energy from fat; Research Diets, Inc., New Brunswick, NJ, USA) for the remainder of the study. At 1 year of age, small mesenteric arteries were dissected and mounted on a wire myograph and responses to phenylephrine, endothelin, acetylcholine, leptin and sodium nitroprusside assessed. Vasoconstriction to endothelin was significantly enhanced in all groups compared with controls (-log effective concentration equal to 50 % of the maximal response (pEC50); P < 0.001). Endothelium-dependent vasodilatation to acetylcholine was significantly blunted in all groups compared with controls (% maximum response; P < 0.01), while dilatation to leptin and sodium nitroprusside was similar in all groups. These data demonstrate that both maternal undernutrition and postnatal high fat lead to vascular alterations and suggest that maternal undernutrition alone is at least as detrimental to offspring endothelial function as a long-term exposure to a high-fat diet in the offspring<br/
Leptin reversal of the metabolic phenotype: evidence for the role of developmental plasticity in the development of the metabolic syndrome
No full textEvents in early life are associated with changes in the risk of disease in later life. There is increasing evidence that these associations are mediated by permanent transcriptional changes in metabolic pathways, in some cases linked to epigenetic alterations. We have proposed that this phenomenon of 'developmental induction' is not a manifestation of pathophysiological processes but rather represents the consequence of developmental decisions made during fetal and early postnatal life to maximize subsequent fitness. However, this fitness advantage is lost if the early and later environments are mismatched. Rats undernourished in utero by maternal underfeeding develop features of the metabolic syndrome, especially if fed on a high-fat diet, but transient neonatal treatment with leptin reverses induction of this adverse metabolic phenotype. This observation demonstrates that developmental programming is reversible and provides strong support for the match-mismatch or predictive model for the origins of developmental programming
Well-known trade mark protection: confusion in EU and Japan
No full textIn this thesis concerning the protection of well-known trade marks against confusion in the European Community Trade Mark (CTM) and Japanese trademark systems, the author critically considers the difficulties in comprehensively defining ‘well-known trade mark’ in the relevant international trade mark instruments. After critical analysis of various definitions of both ‘trade mark’ and ‘well-known trade mark’, she undertakes a comparison of the definitions of the parallel concepts of ‘trade mark of repute’ and ‘syuchi-syohyo’, and also undertakes an assessment as to the extent to which these trade marks are protected against confusion and kondo in the CTM and Japanese systems, respectively. It is concluded that the protection of well- known trade marks against confusion in the CTM and Japan cannot be said to be completely clear, and the author identifies some areas for legal refor
Pre- and postnatal nutritional histories influence reproductive maturation and ovarian function in the rat
No full textBackgroundWhile prepubertal nutritional influences appear to play a role in sexual maturation, there is a need to clarify the potential contributions of maternal and childhood influences in setting the tempo of reproductive maturation. In the present study we employed an established model of nutritional programming to evaluate the relative influences of prenatal and postnatal nutrition on growth and ovarian function in female offspring.MethodsPregnant Wistar rats were fed either a calorie-restricted diet, a high fat diet, or a control diet during pregnancy and/or lactation. Offspring then were fed either a control or a high fat diet from the time of weaning to adulthood. Pubertal age was monitored and blood samples collected in adulthood for endocrine analyses.ResultsWe report that in the female rat, pubertal timing and subsequent ovarian function is influenced by the animal's nutritional status in utero, with both maternal caloric restriction and maternal high fat nutrition resulting in early pubertal onset. Depending on the offspring's nutritional history during the prenatal and lactational periods, subsequent nutrition and body weight gain did not further influence offspring reproductive tempo, which was dominated by the effect of prenatal nutrition. Whereas maternal calorie restriction leads to early pubertal onset, it also leads to a reduction in adult progesterone levels later in life. In contrast, we found that maternal high fat feeding which also induces early maturation in offspring was associated with elevated progesterone concentrations.ConclusionsThese observations are suggestive of two distinct developmental pathways leading to the acceleration of pubertal timing but with different consequences for ovarian function. We suggest different adaptive explanations for these pathways and for their relationship to altered metabolic homeostasis
The Gospel on the Margins: The Ideological Function of the Patristic Tradition on the Evangelist Mark
No full textIn spite of the virtually unanimous patristic opinion that the evangelist Mark was the interpreter of Peter, one of the most prestigious apostolic founding figures in Christian memory, the Gospel of Mark was mostly neglected in the patristic period. Not only is the text of Mark the least well represented of the canonical Gospels in terms of the number of patristic citations, commentaries and manuscripts, the explicit comments about the evangelist Mark reveal some ambivalence about its literary or theological value. In my survey of the reception of Mark from Papias of Hierapolis until Clement of Alexandria, I will argue that the reason why the patristic writers were hesitant to embrace the Gospel of Mark was that they perceived the text to be amenable to the Christological beliefs and social praxis of rival Christian factions. The patristic tradition about Mark may have little historical basis, but it had an important ideological function in appropriating the text in the name of an apostolic authority from the margins or periphery
Reconsidering Arminius: Beyond the Reformed and Wesleyan Divide
No full textThe theology of Dutch theologian Jacob Arminius has been misinterpreted and caricatured in both Reformed and Wesleyan circles. By revisiting Arminius's theology, the book hopes to be a constructive voice in the discourse between so-called Calvinists and Arminians. Traditionally, Arminius has been treated as a divisive figure in evangelical theology. Indeed, one might be able to describe classic evangelical theology up into the twentieth century in relation to his work: one was either an Arminian and accepted his theology or one was a Calvinist and rejected his theology. Although various other movements within evangelicalism have provided additional contour to the movement (fundamentalism, Pentecostalism, etc.), the Calvinist-Arminian 'divide' remains a significant one. What this book seeks to correct is the misinterpretation of Arminius as one whose theology provides a stark contrast to the Reformed tradition as a whole. Indeed, this book will demonstrate instead that Arminius is far more in line with Reformed orthodoxy than popularly believed and show that what emerges as Arminianism in the theology of the Remonstrants and Wesleyan movements was in fact not the theology of Arminius but a development of and sometimes departure from it. This book also brings Arminius into conversation with modern theology. To this end, it includes essays on the relationship between Arminius's theology and open theism and Neo-Reformed theology. In this way, this book fulfills the promise of the title by showing ways in which Arminius's theology—once properly understood—can serve as a resource of evangelical Wesleyans and Calvinists doing theology together today. Abbreviations -- ix Introduction. Reconsidering Arminius: Recasting the Legacy / Mark H. Mann and Mark G. Bilby -- xi-xix Chapter 1. Consecrated through Suffering : the Office of Christ in the Theology of Jacob Arminius / Richard A. Muller -- 1-21 Chapter 2. Was Arminius an Unwitting Determinist? : Another Look at Arminius's Modal Logic / Thomas H. McCall -- 23-37 Chapter 3. Beyond Luther, beyond Calvin, beyond Arminius : the Pilgrims and the Remonstrants in Leiden, 1609-1620 / Jeremy Dupertuis Bangs -- 39-69 Chapter 4. The Loss of Arminius in Wesleyan-Arminian Theology / W. Stephen Gunter -- 71-90 Chapter 5. Jacob Arminius and Jonathan Edwards on the doctrine of creation / Oliver D. Crisp -- 91-112 Chapter 6. Convergence in the "Reformed" theologies of T.F. Torrance and Jacob Arminius / E. Jerome Van Kuiken -- 113-135 Chapter 7. Was Arminius an open theist? : meticulous providence in the theology of Jacob Arminius / John Mark Hicks -- 137-160 Conclusion. Arminius Reconsidered : Thoughts on Arminius and Contemporary Theological Discourse for the Church Today / Keith D. Stanglin -- 161-167 Contributors -- 169Published@book{stanglin2014reconsidering, title= {Reconsidering Arminius: Beyond the Reformed and Wesleyan Divide}, author= {Stanglin, Keith D and Bilby, Mark G and Mann, Mark H}, year= {2014}, publisher= {Kingswood Books}}978142679654
Tissue-specific 5' heterogeneity of PPARa transcripts and their differential regulation by leptin
No full textThe genes encoding nuclear receptors comprise multiple 5'untranslated exons, which give rise to several transcripts encoding the same protein, allowing tissue-specific regulation of expression. Both human and mouse peroxisome proliferator activated receptor (PPAR) ? genes have multiple promoters, although their function is unknown. Here we have characterised the rat PPAR? promoter region and have identified three alternative PPAR? transcripts, which have different transcription start sites owing to the utilisation of distinct first exons. Moreover these alternative PPAR? transcripts were differentially expressed between adipose tissue and liver. We show that while the major adipose (P1) and liver (P2) transcripts were both induced by dexamethasone, they were differentially regulated by the PPAR? agonist, clofibric acid, and leptin. Leptin had no effect on the adipose-specific P1 transcript, but induced liver-specific P2 promoter activity via a STAT3/Sp1 mechanism. Moreover in Wistar rats, leptin treatment between postnatal day 3-13 led to an increase in P2 but not P1 transcription in adipose tissue which was sustained into adulthood. This suggests that the expression of the alternative PPAR? transcripts are in part programmed by early life exposure to leptin leading to persistent change in adipose tissue fatty acid metabolism through specific activation of a quiescent PPAR? promoter. Such complexity in the regulation of PPAR? may allow the expression of PPAR? to be finely regulated in response to environmental factors
Incomprehension or resistance? : the Markan disciples and the narrative logic of Mark 4:1—8:30
No full textThe characterization of the Markan disciples has been and continues to be the object of much scholarly reflection and speculation. For many, the Markan author’s presentation of Jesus’ disciples holds a key, if not the key, to unlocking the purpose and function of the gospel as a whole. Commentators differ as to whether the Markan disciples ultimately serve a pedagogical or polemical function, yet they are generally agreed that the disciples in Mark come off rather badly, especially when compared to their literary counterparts in Matthew, Luke, and John.
This narrative-critical study considers the characterization of the Markan disciples within the Sea Crossing movement (Mark 4:1–8:30). While commentators have, on the whole, interpreted the disciples’ negative characterization in this movement in terms of lack of faith and/or incomprehension, neither of these, nor a combination of the two, fully accounts for the severity of language leveled against the disciples by the narrator (6:52) and Jesus (8:17–18). Taking as its starting point an argument by Jeffrey B. Gibson (1986) that the harshness of Jesus’ rebuke in Mark 8:14–21 is occasioned not by the disciples’ lack of faith or incomprehension but by their active resistance to his Gentile mission, this investigation uncovers additional examples of the disciples’ resistance to Gentile mission, offering a better account of their negative portrayal within the Sea Crossing movement and helping explain many of their other failures.
In short, this study argues that in Mark 4:1–8:26, the disciples are characterized as resistant to Jesus’ Gentile mission and to their participation in that mission, the chief consequence being that they are rendered incapable of recognizing Jesus’ vocational identity as Israel’s Messiah (Thesis A). This leads to a secondary thesis, namely, that in Mark 8:27–30, Peter’s recognition of Jesus’ messianic identity indicates that the disciples have finally come to accept Jesus’ Gentile mission and their participation in it (Thesis B).
“Chapter One: Introduction” offers a selective review of scholarly treatments of the Markan disciples, which shows that few scholars attribute resistance, let alone purposeful resistance, to the disciples.
“Chapter Two: The Rhetoric of Repetition” introduces the methodological tools, concepts, and perspectives employed in the study. It includes a section on narrative criticism, which focuses upon the story-as-discoursed and the implied author and reader, and a section on Construction Grammar, a branch of cognitive linguistics founded by Charles Fillmore and further developed by Paul Danove, which focuses upon semantic and narrative frames and case frame analysis.
“Chapter Three: The Sea Crossing Movement, Mark 4:1–8:30” addresses the question of Markan structure and argues that Mark 4:1–8:30 comprises a single, unified, narrative movement, whose action and plot is oriented to the Sea of Galilee and whose most distinctive feature is the network of sea crossings that transport Jesus and his disciples back and forth between Jewish and Gentile geopolitical spaces.
Following William Freedman, “Chapter Four: The Literary Motif” introduces two criteria (frequency and avoidability) for determining objectively what constitutes a literary motif and provides the methodological basis and starting point for the analyses performed in chapters five and six.
“Chapter Five: The Sea Crossing Motif” establishes and then carries out a lengthy narrative analysis of the Sea Crossing motif, which is oriented around Mark’s use of θάλασσα (thalassa) and πλοῖον (ploion), and “Chapter Six: The Loaves Motif” does the same for The Loaves motif, oriented around Mark’s use of ἄρτος (artos).
Finally, “Chapter Seven: The Narrative Logic of the Disciples (In)comprehension” draws together all narrative, linguistic, and exegetical insights of the previous chapters and offers a single coherent reading of the Sea Crossing movement that establishes Theses A and B.
Metabolic plasticity during mammalian development is directionally dependent on early nutritional status
No full textDevelopmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for most mammalian traits. The metabolic phenotype of adult rats, including the propensity to obesity, hyperinsulinemia, and hyperphagia, shows plasticity in response to prenatal nutrition and to neonatal administration of the adipokine leptin. Here, we report that the effects of neonatal leptin on hepatic gene expression and epigenetic status in adulthood are directionally dependent on the animal's nutritional status in utero. These results demonstrate that, during mammalian development, the direction of the response to one cue can be determined by previous exposure to another, suggesting the potential for a discontinuous distribution of environmentally induced phenotypes, analogous to the phenomenon of polyphenis
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