945 research outputs found
sj-docx-1-ema-10.1177_17411432211034172 - Supplemental material for Gender, networks and academic leadership: A systematic review
No full textSupplemental material, sj-docx-1-ema-10.1177_17411432211034172 for Gender, networks and academic leadership: A systematic review by Daphne L van Helden, Laura den Dulk, Bram Steijn and Meike W Vernooij in Educational Management Administration & Leadership</p
Psoriasis is not associated with cognition, brain imaging markers and risk of dementia: the Rotterdam Study
No full textBased on increased cardio-metabolic comorbidities, inflammation and an overlap in genetics with Alzheimer's disease, psoriasis patients may be at risk for cognitive dysfunction and dementia
The Impact of Incidental Findings Detected During Brain Imaging on Research Participants of the Rotterdam Study: An Interview Study
No full textThis interview study investigates the short- and long-term implications of incidental findings detected through brain imaging on research participants’ lives and their
surroundings. For this study, nine participants of the Rotterdam Scan Study with an
incidental finding were approached and interviewed. When examining research participants’
narratives on the impact of the disclosure of incidental findings, the authors identified five
sets of tensions with regard to motivations for and expectations of research participation,
preferences regarding disclosure, short- and long-term impacts and impacts on self and
others. The paper shows: (1) that the impact of incidental findings may be greater than
participants at first let on; (2) incidental findings can have significant effects on participants’
social environment; and (3) participants may not feel prepared for disclosure even if
incidental findings have been discussed during the informed consent process. The authors
call for investigators to be aware of research participants’ experiences and these short- and
long-term impacts when designing suitable courses of action for the detection and management of incidental findings in research settings
The aging brain: a tale as old as time
No full textThe aging process is biologically complex and there is a large variation in the effects of aging on the human body between as well as within individuals. Similarly, the aging brain is known for its large intra- and inter-individual variability in functioning and structural changes that occur with advancing age. In a nutshell, the brain shrinks with advancing age as a result of brain atrophy and age-related changes in cognition vary considerably across cognitive domains and across individuals. An important challenge in brain aging research in particular is the overlap in changes in brain structure and function in aging and neurodegenerative disease, such as Alzheimer's disease. Though challenging, this overlap also underlines the importance of understanding brain aging to ultimately improve our understanding of neurodegenerative disease. Therefore, the aim of this thesis was to quantify brain aging trajectories and brain aging patterns. These trajectories were used to investigate the association between risk factors and brain aging. Furthermore, I assessed how brain aging can inform disease assessment and prediction.
Emancipation in the net : theatre spectators and the "agency" of network
No full textIn a lecture given during the 49th Counterpoint Review of Small Theatrical Forms in Szczecin, Meike Wagner focuses on the emancipation of the theater viewer and the “agency of the Web.” The author's point of departure are some of Jacques Rancière's theses concerning the viewer as a “storyteller” and a “translator,” as well as a theory of the Internet by Bruno Latour. Using these concepts, Wagner performs an insightful analysis of the audience protests at Covent Garden in 1809 (the Old Price Riots) and the Situation Rooms project (2013) by the Rimini Protokoll group. The author considers the course and efficiency of the emancipation process in institutionalized theaters open to this sort of initiative, or the contrary, those which block the viewers' striving toward freedom
Imaging of Age-related Brain Changes: A Population-based Approach
No full textThe objective of the studies described in this thesis was to investigate with magnetic resonance imaging (MRI) brain changes that may function as preclinical imaging markers for neurodegenerative and cerebrovascular disease. For this goal, advanced MRI techniques were applied in the Rotterdam Scan Study, a large population-based brain imaging study among middle-aged and elderly persons. We studied the prevalence and distribution of age-related brain changes on MRI, investigated associated risk factors and related these brain changes to cognitive functioning.
We found that cerebral microbleeds were present in 1 in 5 persons over age of 60. This prevalence is much higher than reported previously, which in part may be explained by the use of a more sensitive MRI sequence. Furthermore, we showed that risk factors for microbleeds varied according to the location of microbleeds in the brain.
By measuring cerebral blood flow, we assessed that persons with low total brain perfusion had significantly more white matter lesions compared to those with high total brain perfusion. This suggests that tissue hypoperfusion may contribute to white matter lesion pathogenesis.
Microstructural integrity within white matter lesions or normal-appearing white matter was associated with cognitive function, even when taking into account volume of white matter lesions and white matter atrophy. This indicates that the deleterious effect of white matter changes on cognition not only depends on lesion burden or amount of atrophy, but also on characteristics that are not easily evaluated by conventional MRI.
The studies described in this thesis have identified several age-related brain changes that have potential to serve as imaging markers for neurodegenerative or cerebrovascular disease
S5‐01‐04: Imaging Outcomes for Clinical Trials in Different Stages of Alzheimer's Disease
No full text- …
