2,550 research outputs found

    Postal de Claudio Vivas a Maruja Vieira, junio 23 de 1955

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    Postal de Claudio Vivas a Maruja Vieira, felicitándola por el reconocimiento que le fue otorgado a la autora de poemasPostcard from Claudio Vivas to Maruja Vieira, congratulating her for the recognition given to the author of poems.Publicación, fondo Maruja Vieira, carpeta 1, folio

    Fasting-mimicking diet: a metabolic approach for the treatment of breast cancer

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    Purpose of reviewMetabolic reprogramming is a new and potentially targetable hallmark of cancer. In recent years, fasting and fasting-mimicking diets (FMDs) have been tested as anticancer strategies both in preclinical experiments and in clinical trials. In this review, we aim at summarizing the available evidence about the antitumour activity of these approaches in preclinical breast cancer models, as well as results from clinical trials investigating fasting/FMD in breast cancer patients.Recent findingsPreclinical evidence demonstrated that nutrient deprivation boosts the antitumor activity of chemotherapy, immunotherapy or targeted therapies in triple-negative breast cancer (TNBC) and HR+/HER2 models through both cell-autonomous antitumour effects in cancer cells and favourable modifications in intratumor immune cells. Several clinical experiences demonstrated that fasting/FMD is feasible and well tolerated in combination with standard treatments in BC patients, and that it could reduce chemotherapy-related toxicities. Finally, despite the absence of randomized trials demonstrating the antitumor activity of fasting/FMD in breast cancer patients, preliminary clinical reports suggest that this experimental nutritional strategy may enhance chemotherapy activity. Randomized clinical trials are ongoing to validate these results at a larger scale.SummaryFasting/FMD is a promising therapeutic approach in patients with breast cancer; ongoing and future trials will confirm their role in improving breast cancer care

    “Dialogue between Translators and Authors. The Example of Claudio Magris”

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    The paper focuses on the forms of cooperation between authors and their translator(s) in all cases in which the two operate simultaneously. This issue is explored on the example of the Trieste-born author Claudio Magris, who cultivates a very close relationship with most of his translators. Writing and translation have been coexisting in this author throughout his career and have resulted in the heightened sensitivity of Magris the author with regards to translation, as the first part of the analysis shows. The second part describes the dialogue between Magris and the translators of his works, and ends with the more general question of the significance and role of such a form of exchange
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