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Matrici polimeriche idrofile/lipofile, in grado di cedere sostanze farmacologicamente attive a velocità predeterminata
No full textHydrophilic/lipophilic polymeric matrix dosage formulation
No full textAn oral dosage form comprising a pharmaceutical tablet of one or more layers, one of which carries a biologically active substance; the formulation of said tablet includes different percentages of hydrophilic and lipophilic polymeric materials and adjuvant substances. The tablets of the present invention show a release rate which is dependent from the amounts of active substance present in the tablet
Procedimento per la preparazione di compresse farmaceutiche in grado di cedere, secondo schemi predeterminabili, principi attivi poco solubili, in esse veicolati
No full textCompressa farmaceutica, completamente rivestita, per il rilascio controllato di principi attivi che presentano problemi di biodisponibilità legati all'assorbimento gastro-intestinale
No full text
Hydrophilic/lipophilic polymeric matrix dosage formulation
No full textAn oral dosage form comprising a pharmaceutical tablet of one or more layers, one of which carries a biologically active substance; the formulation of said tablet includes different percentages of hydrophilic and lipophilic polymeric materials, and adjuvant substances. The tablets of the present invention show a release rate which is independent from the amounts of active substance present in the tablet
Controlled release pharmaceutical tablets containing an active principle of low water solubility
No full textIt is described a new method for the preparation of pharmaceutical tablets carrying poorly soluble in water principle; this method allows to obtain tablets with fast and/or slow release of the active principle. The peculiar feature is the fact that the poorly soluble in water active principle (es: nifedipine) is treated with a surfactant, during the granulation phase or whatever during the preparation process; the obtained product, subjected to a compression, produces pharmaceutical tablets which show high bioavailability of the carried active principle. This procedure can be used to prepare polymeric matrixes (with modified release), formed by tablets with one or more layers. The procedure of manufacture and the characteristics of the new finished tablet are described
Pharmaceutical tablet, completely coated, for controlled release of active principles that present problems of bioavailability linked to gastro intestinal absorption
No full textDescribed herein is a particular type of pharmaceutical tablet, for oral use, which is formed by one or more layers, and is specifically designed for controlled release of active principles that present problems of bio-availability linked to absorption in the gastro-intestinal tract, and in particular active principles that present an erratic and unpredictable absorption linked to the presence or absence of food at the level of the stomach and/or of the first portion of the small intestine, the said pharmaceutical form being characterized in that it is completely coated with one or more films of a biocompatible and biodegradable polymeric material
Multi-layer controlled release tablet comprising an active layer and one or more barrier layers
No full textAn oral dosage form comprising a pharmaceutical tablet of one or more layers, one of which carries a biologically active substance; the formulation of said tablet includes different percentages of hydrophilic and lipophilic polymeric materials, and adjuvant substances. The tablets of the present invention show a release rate which is independent from the amounts of active substance present in the tablet
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