1 research outputs found
Lutein encapsulated oleic - linoleic acid nanoemulsion boosts oral bioavailability of the eye protective carotenoid lutein in rat model
No full textThere is great interest in emerging colloidal delivery systems to enhance the water solubility and oral
bioavailability of lutein, a hydrophobic carotenoid claimed to possess health benefits. The present study aimed to
design lutein-enriched nanoemulsions with improved physicochemical properties and achieve various health
benefits. The prepared lutein nanoemulsion was characterized and its bioavailability was examined in vitro
(simulated gastrointestinal digestion) and in vivo. The mean size, PDI and zeta potential of the lutein nano�emulsion were 110 ± 8 nm, 0.271 and 36 ± 2 mV, respectively. Furthermore, TEM examination revealed that the
particles are nanosized and spherical. Notably, the aqueous solubility of the nanoemulsion was 726-fold higher
than that of free lutein. The composite nanoemulsion also showed exceptionally higher (87.4 %) in vitro bio�accessibility than nonencapsulated or free lutein (15 %). The in vivo bioavailability of lutein nanoemulsion
(112.6 ng/mL) was much higher than that of nonencapsulated lutein (48.6 ng/mL) and mixed micelles (68.5 ng/
mL) and the tissue distribution pattern of lutein nanoemulsion showed higher lutein accumulation in the liver
(2.80 and 1.70 fold) and eye (1.91 and 1.48 fold) compared to free lutein and mixed micelle-fed groups. These
results suggested that oleic acid-linoleic acid composite nanoemulsions may be a promising delivery system for
lutein and may help enhance the solubility, oral bioavailability and bioefficacy of lutein and could be used as an
ingredient for the formulation of beverages or functional foods
