231 research outputs found
What’s New in Intravenous Anaesthesia? New Hypnotics, New Models and New Applications
Full text linkNew anaesthetic drugs and new methods to administer anaesthetic drugs are continually becoming available, and the development of new PK-PD models furthers the possibilities of using arget controlled infusion (TCI) for anaesthesia. Additionally, new applications of existing anaesthetic drugs are being investigated. This review describes the current situation of anaesthetic drug development and methods of administration, and what can be expected in the near future
Design Considerations for Building a Scalable Digital Version of a Multi-player Educational Board Game for a MOOC in Logistics and Transportation
No full textWith more flexible and large-scale learning environments, new design requirements for games emerge. Massive Open Online Courses (MOOCs) are one of the most important innovations in the learning field. Still, it is a challenge to motivate learners and to keep them motivated in such huge learning environments. To address this challenge, we redesigned a board game targeting at an integrated view on disruption and communication management in an intermodal transportation situation. From the redesign, we have learned that an online game works better with fewer roles, requires immediate feedback, and an engaging way of challenge to keep players motivated. Our findings can inform the design of games for large groups of players in an online environment.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Policy AnalysisOrganisation & Governanc
Innovation in anaesthetic pharmacology:validating models for established drugs and developing models for novel drugs
Full text linkThis thesis focuses on the optimization of hypnotic agents for general anesthesia, with particular attention to propofol and the novel agent remimazolam. The first part discusses the Eleveld model for propofol, a broadly applicable pharmacokinetic-pharmacodynamic (PK-PD) model suitable for a wide range of patient groups. The model was clinically validated in combination with Target-Controlled Infusion (TCI) and demonstrated reliable control of anesthesia depth in children, adults, elderly, and obese patients. Although the model proved effective, some interindividual variability remained. Therefore, a Bayesian decision support system was developed to further refine dosing, but significant improvement over standard care was not observed, likely due to the high skill level of the anesthesiologists involved.The second part of the thesis investigates remimazolam, a short-acting benzodiazepine with rapid onset and a favorable side effect profile. In a European study, remimazolam was shown to be non-inferior to propofol and resulted in a lower incidence of post-induction hypotension. Subsequent research examined the PK and PD of remimazolam in a TCI setting, as well as its interaction with remifentanil. The studies demonstrated that remimazolam is well titratable but susceptible to acute tolerance, possibly mediated by its metabolite CNS7054. An additive interaction with remifentanil was also observed, enhancing the sedative effect.In summary, this thesis demonstrates that propofol can be administered effectively and safely using a universally applicable model, and that remimazolam represents a promising alternative
Using space syntax to assess accessibility of multimodal urban hubs and seamless mobility within the hubs Case study Delft-Campus train station
No full textMultimodal hubs connect different modes, allowing people to switch from one mode to another and seamlessly access/egress to/from their origin/destinations. However, there are limited methods to estimate the impact of future measures on the accessibility of multimodal hubs. These future measures could be wide reaching, among others, introduction of different schemes in the planning of the hub or introduction of new modes at multimodal hubs. This study provides interdisciplinary cross-cutting method including transport and urbanism literatures, by using Space Syntax method. This method allows the transport planners to analyse and compare the current situation and the proposed development plan. In this research, we show how changes made in urban spatial configuration can impact the accessibility of intermodal hubs. To learn about the impacts of the spatial configuration of a city on station design, we performed a case study at Delft Campus train station in the Netherlands, which is under construction to become a multimodal hub. Firstly, we analyse the current situation and then the proposed development plan in terms of, integration, choice, accessibility and intelligibility, using segment analyses. Furthermore, the immediate surrounding areas of the station have been analysed by Visual Graphic Analysis to find visual accessibility within the hub. Although the municipality proposed plans claim that the station’s accessibility would be enhanced, our method indicate otherwise and the proposed changes are not highly effective in increasing accessibility. Finally, some design recommendations for multimodal hubs are proposed. This study is a prerequisite for designing the multimodal hubs considering emerging modes.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Transport and PlanningTransport and Plannin
Erratum: Corrigendum to “Development and initial validation of the Role Strain Questionnaire for Junior Athletes (RSQ-JA)” (Psychology of Sport and Exercise (2016) 24 (168–178)(S146902921630022X)(10.1016/j.psychsport.2016.02.004))
No full textThe authors regret to let us know that there is an authorship change in the article. The authors would like add another author to the article namely Fiona Chun Man Ling, as they believe that she has made a substantial intellectual contribution to this work and is deserving authorship. As such, they would like to change the reference of the article to: Fleur E.C.A. van Rens a, *, Erika Borkoles b, Damian Farrow a, c, Thomas Curran d, Fiona Chun Man Ling a, Remco C.J. Polman e The authors would like to apologise for any inconvenience caused
Measuring microfinance access : building on existing cross-country data
Full text linkGiven the acknowledged need for a new effort to expand the set of available data on direct access to financial services, including a focus on access by those at low income, Honohan provides a selective review of the diverse sources of data that exist and considers how best to build on them. He proposes a basic framework within which to consider the analysis of the interesting questions: (1) How does access affect poverty and productivity? and (2) What hinders access? The author discusses existing and potential contribution of household and business user surveys, surveys of providers and their regulators, and surveys of experts, and assesses their relative strengths.Banks&Banking Reform,Environmental Economics&Policies,Health Economics&Finance,Poverty Assessment,Governance Indicators
Development of a scale to measure social capital in recreation and sport clubs
Full text linkSocial capital's measurement has been limited and an effective scale is needed. This research employed focus groups and interviews and a panel of experts to provide understanding and items for a social capital scale in sport and recreation setting. After a pilot study the Club Social Capital Scale (CSCS) was completed by 1,079 members of sport and recreation clubs. This 42-item scale included the factors trust, friendship, acceptance, reciprocity, norms, and governance. Exploratory factor analysis resulted in a 20-item four component (governance, norms, friendship-acceptance, and trust-reciprocity) CSCS. Confirmatory factor analysis confirmed the potential four or five factor model and the hierarchical structure. The CSCS is the first psychometrically developed instrument to measure the factors underlying social capital rather than its outcomes. It can inform policy makers or sport and recreation administrators to establish baseline social capital in their organization and the efficacy of interventions or changes in policy. © 2018, © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2018, © Tom Forsell, John Tower, and Remco Polman
Quenched Central Limit Theorems for the Ising Model on Random Graphs
Full text linkThemain goal of the paper is to prove central limit theorems for the magnetization
rescaled by the square root of N for the Ising model on random graphs with N vertices.Both random quenched
and averaged quenched measures are considered.We work in the uniqueness regime β > βc
or β > 0 and B not equal to 0, where β is the inverse temperature, βc is the critical inverse temperature
and B is the external magnetic field. In the random quenched setting our results apply to
general tree-like random graphs (as introduced by Dembo, Montanari and further studied by
Dommers and the first and third author) and our proof follows that of Ellis in Z^d. For the
averaged quenched setting, we specialize to two particular random graph models, namely
the 2-regular configuration model and the configuration model with degrees 1 and 2. In
these cases our proofs are based on explicit computations relying on the solution of the one
dimensional Ising model
Parsifal a Game Opera: Experiential Learning in Gameful Performance Art
No full textRichard Wagner’s Parsifal was recently rewritten and performed as a‘game opera’.We used observations, questionnaires, and interviews to study howthe 700+ audience were facilitated to experientially learn about the show’s mainthemes: compassion and collaboration. This case study contributed to ourunderstanding how performance art may improve games for learning and trainingpurposes, many of which now are notoriously ‘boring’. We concluded thatperformance art’s main contribution, in particular to games discussing fundamentalvalues such as compassion, is to captivate players and ‘lure’ them intotheir natural behaviour. Thus the Parsifal game opera emotionally confronted itsaudience with their – callous and selfish – behaviour and intensified their learningthrough embodied experiences. However, some players lacked time and supportto (collectively) reflect on their experiences and lacked catharsis. Therefore, werecommend using gameful performance art for learning and training purposes,provided that all activities in experiential learning are sufficiently facilitated.Post-print versionPolicy Analysi
Designing for climatic phenomena: Exploring the architectural potential of climate responsive design
No full textExcessive amounts of fossil energy have disqualified climatic considerations as boundary factors for architecture. This has limited architects to operate in the visual realm, while the invisible senses that make up climatic design are generally disregarded. As a result contemporary buildings are usually unable to provide balanced living conditions without the support of external sources of energy. When climatic phenomena are considered in building design, architecture can generate an informed response through its geometry. By allowing the local climatic context to influence archetypes and low-tech design solutions, buildings become able to benefit from their environmental energy potential through architectural means. Such climate responsive buildings reflect their surroundings through architecture, making them highly location specific. This thesis examines the bioclimatic design philosophy in order to connect architectural thinking to climatic considerations. 9 buildings that are based on geometric principles found in sunlight, solar heat and wind show how architectural methods and techniques can be used to create climatically balanced living environments
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