415 research outputs found
Utilizing biomarkers in colorectal cancer: an interview with Ajay Goel
No full text Ajay Goel speaks to Rachel Jenkins, Commissioning Editor. Ajay Goel, PhD, is a Professor and Director, Center for Gastrointestinal Research, and Director, Center for Translational Genomics and Oncology, at the Baylor Scott & White Research Institute, Baylor University Medical Center in Dallas, Texas. Dr Goel has spent more than 20 years researching cancer and has been the lead author or contributor to over 240 scientific articles published in peer-reviewed international journals and several book chapters. He is also a primary inventor on more than 15 international patents aimed at developing various biomarkers for the diagnosis, prognosis and prediction of gastrointestinal cancers. He is currently using advanced genomic and transcriptomic approaches to develop novel DNA- and miRNA-based biomarkers for the early detection of colorectal cancers. In addition, he is researching the prevention of gastrointestinal cancers using integrative and alternative approaches, including botanical products such as curcumin (from turmeric) and boswellia. Dr Goel is a member of the American Association for Cancer Research (AACR) and the American Gastroenterology Association (AGA) and is on the international editorial boards of several journals including Gastroenterology, Clinical Cancer Research, Carcinogenesis, PLoS ONE, Scientific Reports, Epigenomics, Future Medicine, Alternative Therapies in Heath and Medicine and World Journal of Gastroenterology. He is also actively involved in peer-reviewing activities for more than 100 international scientific journals and various grant review panels of various national and international funding organizations. His research has been actively funded by various private and federal organizations, including funding from the National Cancer Institute (NCI) at the NIH, American Cancer Society (ACS) and other state organizations. He has won more than dozen awards and honors, including the Union of European Gastroenterology Federation's Distinguished Researcher Award, multiple Poster of Distinction Awards from the AGA, and Visiting Professorships from various national and international academic institutions and academic bodies. Some of his key research interests include: Understanding the basic genetics and epigenetic basis of gastrointestinal cancers; Use of epigenetic markers, both DNA and RNA, for the early detection of colorectal, pancreatic and other gastrointestinal cancers; Personalized medicine and treatment of gastrointestinal cancers; Chemoprevention, using complementary and alternative approaches using nutraceuticals such as curcumin, green tea, resveratrol and other botanicals. </jats:p
Alternative technique of cervical spinal stabilization employing lateral mass plate and screw and intra-articular spacer fixation
No full textAim: The author discusses an alternative technique of segmental cervical spinal fixation. Material and Methods: The subtleties of the technique are discussed on the basis of experience with 3 cases with a follow-up of between 30 and 36 months. Technique: The technique involves debridement of facetal articular cartilage, distraction of facets, jamming of ′Goel spacer′ into the articular cavity and fortification of the fixation by lateral mass plate and screw fixation. The ′double-insurance′ method of fixation is safe for vertebral artery, nerve roots and spinal neural structures and the fixation is strong. Conclusions: The discussed technique is safe and provides a strong fixation and a ground for ultimate arthrodesis
Author Reply Re: Goel A. Research training during residency. Indian J Urol 2017;33:257-8
No full textAlkali-free bioactive glass composition, U.S. Patent 9,238,044
No full textThe present invention relates to development of bioactive glass/glass-ceramic composition that are able to promote a fast deposition layer of carbonated hydroxyapatite upon immersion in simulated body fluid (SBF) for time periods as short as one hour. Such composition might include fluorides, and a variety of oxides (or their precursor compounds), such as Na2O—Ag2O—SrO—CaO—MgO—ZnO—P2O5—SiO2—Bi2O3—B2O3—CaF2, be prepared by the melt route or by the sol-gel process, with the specific composition and the preparation route selected according to the intended functionalities, which can present controlled biodegradation rate and bactericidal activity. The powders derived from glass melts purred in cold water (frits) may completely densify by sintering at temperatures up to 800° C. without devitrification, resulting in bioglass compacts with high flexural strength (˜85 MPa). The bioactive glass powders prepared by sol-gel densify at lower temperatures due to their higher specific surface area and reactivity
Towards Sustainability of Project-based Learning in Higher Education
No full textTowards Sustainability of Project-based Learning in Higher Education
Application of an active comparator-based benefit-risk Assessment in evaluating clinical trial design features of a new chemical entity using a Bayesian decision-theoretic framework.
No full textUniversity of Minnesota Ph.D. dissertation. June 2010. Major: Social, Administrative, and Clinical Pharmacy. Advisor:Richard C. Brundage, Ph.D. 1 computer file (PDF); ix, 129 pages, appendix A. Ill. (some col.)During the drug development process, drug candidates are screened for their efficacy and
toxicity. Dose selection is a crucial part of drug development and specifying the right
dose imparts pharmacological activity while minimizing side effects. Evaluation of the
benefit/risk ratio is typically done by examining the effect of a drug on efficacy and
safety endpoints. However, this comparison can be difficult when there are multiple
endpoints that are clinically and commercially relevant. A decision-based clinical utility
is proposed and evaluated to aid in dose selection. A dose is viable if it has higher
efficacy and lower toxicity than the values specified in multi-attribute decision criteria.
PD 0200390 is a ligand of the α2δ subunit of the voltage-gated calcium channel being
investigated for the treatment of primary insomnia and non-restorative sleep. Wake after
sleep onset and number of awakenings are the measures of sleep consolidation while ease
of awakening and morning behavior following wakefulness are the measures of residual
effects. The objective of this research is to select a dose that maximizes the probability of
a decision criterion characterized over safety and efficacy attributes. Data is obtained
from two phase II double blind, randomized, placebo controlled crossover studies in
subjects with primary insomnia. Dose response models are developed as hierarchical nonlinear
model using NONMEM® and WinBUGS®. A Sensitivity analysis is performed to
test the robustness of the selected dose with varying decision attributes.Goel, Varun. (2010). Application of an active comparator-based benefit-risk Assessment in evaluating clinical trial design features of a new chemical entity using a Bayesian decision-theoretic framework.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/93902
Ebola outbreak 2014-2015: An update
No full textThe 2014–2015 Ebola epidemic is the largest in history, affecting multiple countries in West Africa. In late July 2014, the World Health Organization (WHO) declared the outbreak a Grade 3 emergency, its highest level of any emergency response. In early August, they declared it a public health emergency of international concern, meaning it is a serious public health event that endangers international public health. Indeed, by the end of September 2014, the United Nations stated the outbreak is “a threat to international peace and security.” Guinea located on the Atlantic coast of West Africa, is the first country in this geographical region in which an outbreak of Ebola virus disease has occurred. Cases having been confirmed in other countries include Guinea, Liberia, and Sierra Leone. There were a small number of cases reported in Nigeria and Mali and a single case reported in Senegal; however, these cases were contained with no further spread in these countries. Confirmed imported cases have occurred in the United States, Italy, Spain, and the United Kingdom. The WHO declared the end of the Ebola outbreak in Liberia on May 9, 2015 but on June 29, routine surveillance again detected a new confirmed case of Ebola in Liberia. On November 18, 2014, India has quarantined a man who was cured of Ebola in Liberia. As of August 21, 2015, the cumulative number of probable, suspected, and laboratory-confirmed cases attributed to Ebola virus (EBOV) is 28,036, including 11,301 deaths. Zaire EBOV strain has been identified as causative agent for 2014 Ebola epidemic
From Tainted to Sainted: the Interracial Marriage as Cultural Evangelism
No full textThe article talks about interracial relationships viewed as cultural evangelism. The author mentions that viewing interracial marriage as the ultimate indicator of racial progress leaves the cognitive imprint that underlies all race relations. Professor Goel introduces the four archetypes of interracial relations that emanated from the four historical institutions such as the Civilized White and Colored Savage, the White Colonizer and Colored Subject, the White Master and Colored Slave, and the White Missionary and Colored Heathen. An analysis of the social and legal aspects of interracial marriages and interracial families is also presented
Community-based organisations: role in settling immigrants
No full textIt has been well acknowledged in the literature that successful settlement of new arrivals (both international and interstate) and their families is crucial for theirintegration and well-being in a host society. This will also result in population sustainability and meetingindustry requirements in regional areas. This chapter posits that community-based organisations (CBOs) are in a unique position to provide settlement services which are socially inclusive and evolve community participation under immigration department policy guidelines. Thechapter illustrates how a community development approach is a useful theory/constructto guide the practice of a community-based organisation that isproviding settlement services to new immigrants. This is demonstrated by using a case study of the 'Settling our Future' program provided through one of the community-basedorganisations in aregional city of South Australia.The author demonstrates that community development principles and approaches are the backbone of providing effective servicesto meet the needs of new arrivals in the regional town. The chapterfurther examines the role of the community development worker as a facilitator in establishing, developing and sustaining these initiatives which have a community basis
Author Reply Re: Goel A. Research training during residency. Indian J Urol 2017;33:257-8
No full text- …
