1,695 research outputs found
T.J. Stiles: “The Commodore’s Patriotism: Cornelius Vanderbilt’s Path to the Founding of Vanderbilt University”
No full textIncludes descriptive metadata provided by producer in MP4 file: "Chancellor's Lecture Series - Videos - T.J. Stiles: 'The Commodore’s Patriotism: Cornelius Vanderbilt’s Path to the Founding of Vanderbilt University'." By Vanderbilt University. T.J. Stiles, Pulitzer Prize-winning author and historian, speaks Sept. 29, 2010 as part of the Chancellor's Lecture Series. Stiles wrote the 2009 biography The First Tycoon: The Epic Life of Cornelius Vanderbilt. Chancellor Nicholas Zeppos introduces Stiles. Stiles takes questions after his lecture
Cwbr Author Interview: Custer\u27s Trials: A Life On The Frontier Of A New America
No full textInterview with T.J. Stiles, author of Custer\u27s Trials: A Life on the Frontier of a New America Interviewed by Tom Barber
Civil War Book Review (CWBR): The Civil War Book Review is pleased to speak with T.J. Stiles, winner of multiple awards for biography and author of Jesse James: Last Rebel of the Civil War and The First Tycoon: The Epic Life of Cornelius Vanderbilt. Today we get to discuss his most recent work Custer\u27s Trials: A Life on the Frontier of a New America. Mr. Stiles, thank you for joining us today. T.J. Stiles: Thanks very much for interviewing me...
Effects of chronic agomelatine administration on the expression of a panel of genes in various brain areas of rats
No full textPresentation P.2.d.019T.J. Varcoe, M. Salkeld, E. Mocaer, L. Seguin, D.J. Kennawa
Considerations in selecting postoperative analgesia for pregnant sheep following fetal instrumentation surgery
No full textAbstract not availableTamara J. Varcoe, Jack R.T. Darby, Kathryn L. Gatford, Stacey L. Holman, Pearl Cheung, Mary J. Berry, Michael D. Wiese and Janna L. Morriso
Metabolic consequences of timed feeding in mice
No full textNo abstract availableNurulaini Abu Shamsi, Mark David Salkeld, Leewen Rattanatray, Athena Voultsios, Tamara Jayne Varcoe, Michael James Boden, David John Kennawa
Circadian regulation of reproduction: From gamete to offspring
No full textP01326625; Grants: GNT0519315
Link to a related website: https://digital.library.adelaide.edu.au/dspace/bitstream/2440/81758/1/hdl_81758.pdf, Open Access via UnpaywallFew challenges are more critical to the survival of a species than reproduction. To ensure reproductive success, myriad aspects of physiology and behaviour need to be tightly orchestrated within the animal, as well as timed appropriately with the external environment. This is accomplished through an endogenous circadian timing system generated at the cellular level through a series of interlocked transcription/translation feedback loops, leading to the overt expression of circadian rhythms. These expression patterns are found throughout the body, and are intimately interwoven with both the timing and function of the reproductive process. In this review we highlight the many aspects of reproductive physiology in which circadian rhythms are known to play a role, including regulation of the estrus cycle, the LH surge and ovulation, the production and maturation of sperm and the timing of insemination and fertilisation. We will also describe roles for circadian rhythms in support of the preimplantation embryo in the oviduct, implantation/placentation, as well as the control of parturition and early postnatal life. There are several key differences in physiology between humans and the model systems used for the study of circadian disruption, and these challenges to interpretation will be discussed as part of this review. (C) 2013 Elsevier Ltd. All rights reserved.M.J. Boden, T.J. Varcoe, D.J. Kennawa
Timing is everything: maternal circadian rhythms and the developmental origins of health and disease
No full textLink to a related website: https://physoc.onlinelibrary.wiley.com/doi/pdfdirect/10.1113/JP276992, Open Access via UnpaywallAbstract not availableTamara J. Varco
The reliance on α‐adrenergic receptor stimuli for blood pressure regulation in the chronically hypoxaemic fetus is not dependent on post‐ganglionic activation
No full textKey points: Chronic hypoxaemia is associated with intrauterine growth restriction (IUGR) and a predisposition to the development of hypertension in adult life. IUGR fetuses exhibit a greater reliance on α-adrenergic activation for blood pressure regulation. The fetal blood pressure response to post-ganglionic blockade is not different between control and IUGR fetuses. The decrease in mean arterial pressure is greater in the IUGR sheep fetus after α-adrenergic receptor blockade at the level of the vasculature and this is inversely related to fetal urn:x-wiley:00223751:media:tjp14494:tjp14494-math-0001. The increased reliance that the IUGR fetus has on α-adrenergic activation for maintenance of mean arterial pressure is not a result of increased post-ganglionic sympathetic activation. Abstract: Intrauterine growth restriction (IUGR) is associated with an increased risk of cardiovascular disease in adult life. Placental restriction (PR) in sheep results in chronic hypoxaemia and early onset IUGR with increased circulating plasma noradrenaline concentrations. These IUGR fetuses exhibit a greater decrease in mean arterial pressure (MAP) during α-adrenergic blockade. We aimed to determine the role of post-ganglionic sympathetic activation with respect to regulating MAP in IUGR fetal sheep. PR was induced by carunclectomy surgery prior to conception. Fetal vascular catheterization was performed at 110–126 days gestational age (GA) (term, 150 days) in nine control and seven PR-IUGR fetuses. The fetal blood pressure response to both a post-ganglionic and an α-adrenergic receptor blocker was assessed at 116–120 days GA and/or 129–131 days GA. The effect of both post ganglionic and α-adrenergic blockade on fetal blood pressure was then compared between control and IUGR fetuses at both GAs. There was no difference in the effect of post-ganglionic blockade on MAP in control and IUGR fetal sheep at either 116–120 days GA or 129–131 days GA. α-adrenergic receptor blockade decreased MAP to the same extent in both control and IUGR fetuses at 116–120 days GA. At 129–131 days GA, the drop in MAP in response to α-adrenergic receptor blockade was greater in IUGR fetuses than controls. There was a significant inverse relationship between the drop in MAP in response to α-adrenergic receptor blockade at both GAs with fetal urn:x-wiley:00223751:media:tjp14494:tjp14494-math-0002. Thus, the increased dependence on α-adrenergic activation for blood pressure regulation in the chronically hypoxaemic IUGR fetus is not a result of increased post-ganglionic sympathetic activation.Jack R. T. Darby, Tamara J. Varcoe, Stacey L. Holman, I. Caroline McMillen, Janna L. Morriso
The impact of intrauterine growth restriction on cytochrome P450 enzyme expression and activity
No full textWith the increased prevalence of non-communicable disease and availability of medications to treat these and other conditions, a pregnancy free from prescribed medication exposure is rare. Up to 99% of women take at least one medication during pregnancy. These medications can be divided into those used to improve maternal health and wellbeing (e.g., analgesics, antidepressants, antidiabetics, antiasthmatics), and those used to promote the baby's wellbeing in either fetal (e.g., anti-arrhythmics) or postnatal life (e.g., antenatal glucocorticoids). These medications are needed for pre-existing or coincidental illnesses in the mother, maternal conditions induced by the pregnancy itself through to conditions that arise in the fetus or that will be encountered by the newborn. Thus, medications administered to the mother may be used to treat the mother, the fetus or both. Metabolism of medications is regulated by a range of physiological processes that change during pregnancy. Other pathological processes such as placental insufficiency can in turn have both immediate and lifelong adverse health consequences for babies. Individuals born growth restricted are more likely to require medications but may also have an altered ability to metabolise these medications in fetal and postnatal life. This review aims to determine the effect of suboptimal fetal growth on the fetal expression of the drug metabolising enzymes (DMEs) that convert medications into active or inactive metabolites, and the transporters that remove both these medications and their metabolites from the fetal compartment.Grace M. McBride, Michael D. Wiese, Jia Yin Soo, Jack R.T. Darby, Mary J. Berry, Tamara J. Varcoe, Janna L. Morriso
Flow patterns around longitudinal training dams
No full textWith the intention to reduce the negative effects of ongoing bed erosion, as well as to improve several other river functions such as protection against floods, provision of safe and efficient navigation and ecology, a ‘pilot project longitudinal training dams’ was initiated. The training dams have recently been implemented in the Waal between Tiel and Sind Andries. In this project, river groynes have been completely removed and replaced by dams that lie parallel to the river bank. With help of the longitudinal training dams, a two-channel river system is created in which the river is divided into a main and side channel. The dams are placed in a continuous manner with openings in between that are relatively small compared to the dam length. At the beginning and end of the dam an inlet and outlet region is situated, as shown in Fig. 1. The combination of inlet and openings allows for water and sediment to be divided between the main and the side channel. Both inlet and openings are constructed with the help of a porous rock-layer. The crest heights can be altered by adding or removing stones. This is expected to influence the amount of water and sediment entering the side channel and can therefore be used as a regulation tool. A.J.F. Hoitink, T.V. de Ruijsscher, T.J. Geertsema, B. Makaske, J. Wallinga, J.H.J. Candel, J. Poelman (Eds.) NCR days 2017, Febr. 1-3, 2017. Book of abstracts, NCR publication 41-2017.Rivers, Ports, Waterways and Dredging EngineeringHydraulic Structures and Flood RiskEnvironmental Fluid Mechanic
- …
