177,752 research outputs found
What are the pharmacotherapeutic considerations for the treatment of myasthenia gravis?
No full textn.a (editorial
Antibody Therapies in Autoimmune Neuromuscular Junction Disorders: Approach to Myasthenic Crisis and Chronic Management
No full textMyasthenia gravis (MG) is a neurological autoimmune disorder characterized by muscle weakness and fatigue. It is a B cell–mediated disease caused by pathogenic antibodies directed against various components of the neuromuscular junction (NMJ). Despite the wide range of adverse effects, current treatment is still based on non-specific immunosuppression, particularly on long-term steroid usage. The increasing knowledge regarding the pathogenic mechanisms of MG has however allowed to create more target-specific therapies. A very attractive therapeutic approach is currently offered by monoclonal antibodies (mAbs), given their ability to specifically and effectively target different immunopathological pathways, such as the complement cascade, B cell–related cluster of differentiation (CD) proteins, and the human neonatal Fc receptor (FcRn). Up to now, eculizumab, a C5-directed mAb, has been approved for the treatment of generalized MG (gMG) and efgartigimod, a FcRn inhibitor, has just been approved by the U.S. Food and Drug Administration for the treatment of anti-acetylcholine receptor (AChR) antibody positive gMG. Other mAbs are currently under investigation with encouraging preliminary results, further enriching the new range of therapeutic possibilities for MG. This review article provides an overview of the present status of mAb-based therapies for MG, which offer an exciting promise for better outcomes by setting the basis of a precision medicine approach
Finite volume model of a flat plate cogenerative collector: thermodynamic and experimental analysis
No full textOptimal Control of Polygeneration Systems Including Photovoltaic/thermal Collectors and Solar Assisted Heat Pumps
No full textgasparrini/UKB-confounding
No full textAn theoretical and empirical evaluation of confounding mechanisms in the analysis of the health effects associated with long-term exposure to air pollution, with a case-study example using the UK Biobank cohort. This repository stores the updated R code to reproduce the analysis presented in the article: Vanoli J, et al. Confounding issues in air pollution epidemiology: an empirical assessment with the UK Biobank cohort. International Journal of Epidemiology. 2025;54(5):dyaf163. DOI: 10.1093/ije/dyaf163
Paso Vanoli: una instalación del Holoceno tardío en valles fluviales del sudoeste bonaerense
No full textThis paper presents the studies performed on an archaeological collection from Paso Vanoli site, housed at the Departamento Humanidades, UNS. Field works were carried out in the late 1970´s by Lic. Pérez Amat. Paso Vanoli is a ford in the lower Arroyo Napostá (Napostá Stream) in the area of urban common land of Bahía Blanca (38º 40´S; 62º 13´O), in Buenos Aires Province. It is a stratigraphic site located on a dune on the right bank of the stream. The collection is composed of lithics, pottery and human and faunistic remains. This paper presents ca. 700 yrs. BP radiocarbon dating and reports archaeofaunal and technological data. Lithic resources procurement, artifactual diversity and subsistence are discussed. It is proposed that the site was a residential base related to a spatially segregated burial. The site provides novel information on the mobility circuits in the southwest of Buenos Aires province in the Late Holocene.En este trabajo se presentan los estudios realizados sobre la colección arqueológica del sitio Paso Vanoli, conservada en el Dpto. de Humanidades de la UNS. Los trabajos de campo fueron llevados a cabo en la década de 1970 por la Lic. Pérez Amat. Paso Vanoli es un vado en el valle inferior del arroyo Napostá en el ejido urbano de Bahía Blanca (38º 40´S; 62º 13´O), provincia de Buenos Aires. Es un sitio en estratigrafía, emplazado sobre un médano, en la margen derecha del arroyo. La colección está integrada por artefactos líticos, cerámica, materiales faunísticos y restos óseos humanos. En este trabajo se presenta un fechado radiocarbónico de ca. 700 años AP y se informan los datos relacionados con las arqueofaunas y la tecnología. Se discute el abastecimiento de recursos líticos, la variabilidad artefactual y la subsistencia. Se propone que el sitio fue una base residencial vinculada con un sector de inhumaciones espacialmente segregado. Este sitio aporta información novedosa sobre los circuitos de movilidad en el sudoeste bonaerense durante el Holoceno tardío final
INTERNET BASED DEVELOPMENT OF AN OPEN SOURCE LOW-COST CNC
No full textIn this paper we show how to realize a low-cost numerical system, based on an “open source” software called EMC (Enhanced Machine Control). First, we assembled a low cost CNC workstation with a remote control by means of an online computer with a webcam, as an example of the software's potentiality. Moreover, we translated a graphical user interface (AXIS), in co-operation with the international development community, in order to improve its userfriendliness
A More Simple G-Code Programming within an Open Source CNC System
No full textIn this paper we introduce the utilization of a new CNC programming language, named O-Word, a way to implement several branching routines into the EMC interpreter. It opens new interesting possibilities to programmers who can build subroutines, loops, and conditionals while taking advantage of the interpreter's use of variables and computation. Therefore, it allows us to make pieces describing theirs features instead of tool's movements. We will demonstrate a new complex routine in order to show both the language syntax and its potential for advanced applications
Paso Vanoli: una instalación del Holoceno tardío en valles fluviales del sudoeste bonaerense
No full textEn este trabajo se presentan los estudios realizados sobre la colección arqueológica del sitio Paso Vanoli, conservada en el Dpto. de Humanidades de la UNS. Los trabajos de campo fueron llevados a cabo en la década de 1970 por la Lic. Pérez Amat. Paso Vanoli es un vado en el valle inferior del arroyo Napostá en el ejido urbano de Bahía Blanca (38º 40´S; 62º 13´O), provincia de Buenos Aires. Es un sitio en estratigrafía, emplazado sobre un médano, en la margen derecha del arroyo. La colección está integrada por artefactos líticos, cerámica, materiales faunísticos y restos óseos humanos. En este trabajo se presenta un fechado radiocarbónico de ca. 700 años AP y se informan los datos relacionados con las arqueofaunas y la tecnología. Se discute el abastecimiento de recursos líticos, la variabilidad artefactual y la subsistencia. Se propone que el sitio fue una base residencial vinculada con un sector de inhumaciones espacialmente segregado. Este sitio aporta información novedosa sobre los circuitos de movilidad en el sudoeste bonaerense durante el Holoceno tardío final.This paper presents the studies performed on an archaeological collection from Paso Vanoli site, housed at the Departamento Humanidades, UNS. Field works were carried out in the late 1970´s by Lic. Pérez Amat. Paso Vanoli is a ford in the lower Arroyo Napostá (Napostá Stream) in the area of urban common land of Bahía Blanca (38º 40´S; 62º 13´O), in Buenos Aires Province. It is a stratigraphic site located on a dune on the right bank of the stream. The collection is composed of lithics, pottery and human and faunistic remains. This paper presents ca. 700 yrs. BP radiocarbon dating and reports archaeofaunal and technological data. Lithic resources procurement, artifactual diversity and subsistence are discussed. It is proposed that the site was a residential base related to a spatially segregated burial.
The site provides novel information on the mobility circuits in the southwest of Buenos Aires province in the Late Holocene.Facultad de Ciencias Naturales y Muse
Optimal control of polygeneration systems including photovoltaic/thermal collectors and solar assisted heat pumps
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