8,642 research outputs found

    Reading by Jo Walton

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    Award-winning author and Mythopoeic Fantasy Award finalist Jo Walton will read from her works and answer questions from the audience

    sj-docx-1-mso-10.1177_20552173221105642 - Supplemental material for Patient-reported outcome measures in MS: Do development processes and patient involvement support valid quantification of clinically important variables?

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    Supplemental material, sj-docx-1-mso-10.1177_20552173221105642 for Patient-reported outcome measures in MS: Do development processes and patient involvement support valid quantification of clinically important variables? by Trishna Bharadia, Jo Vandercappellen, Tanuja Chitnis, Piet Eelen, Birgit Bauer, Giampaolo Brichetto, Andrew Lloyd, Hollie Schmidt, Miriam King, Jennifer Fitzgerald, Thomas Hach and Jeremy Hobart in Multiple Sclerosis Journal – Experimental, Translational and Clinical</p

    The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer

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    Chemokines are chemotactic cytokines which recruit leukocytes to inflammatory sites. They also affect tumor development and metastasis by acting as growth factor, by attracting pro- or anti-tumoral leukocytes or by influencing angiogenesis. Platelet factor-4 (CXCL4/PF-4) was the first chemokine shown to inhibit angiogenesis. CXCL4L1/PF-4var, recently isolated from thrombin-stimulated platelets, differing from authentic CXCL4/PF-4 in three carboxy-terminally located amino acids, was found to be more potent than CXCL4/PF-4 in inhibiting angiogenesis and tumor growth. Both glycosaminoglycans (GAG) and CXCR3 are implicated in the activities of the PF-4 variants. This report reviews the current knowledge on the role of CXCL4/PF-4 and CXCL4L1/PF-4var in physiological and pathological processes. In particular, the role of CXCL4/PF-4 in cancer, heparin-induced thrombocytopenia and atherosclerosis is described.sponsorship: The authors thank Prof. G. Opdenakker, Prof. S. Liekens, Prof. H. Heremans (Rega Institute, Leuven, Belgium), Prof. G. Laureys (University of Gent, Belgium), Prof. C. Uyttenhove (Universite Catholique de Louvain, Belgium) and Prof. P. Allavena (Istituto Clinico Humanitas, Milan, Italy) for critically reading the manuscript. This work was supported by the Fund for Scientific Research of Flanders (F.W.O-Vlaanderen), K.U.L. Center of Excellence Credit EF/05/15, Regional Government of Flanders Concerted Research Actions, Interuniversity Attraction Poles Program-Belgian Science Policy and European Union 6FP EC Contract INNOCHEM grant LSHB-CT-2005-518167. J. Vandercappellen is a research assistant of the F.W.O.-Vlaanderen. (Fund for Scientific Research of Flanders (F.W.O-Vlaanderen), K.U.L. Center of Excellence Credit|EF/05/15, Regional Government of Flanders Concerted Research Actions, Interuniversity Attraction Poles Program-Belgian Science Policy, European Union|LSHB-CT-2005-518167)status: Publishe

    sj-docx-1-dhj-10.1177_20552076231173531 - Supplemental material for Development and usability testing of your MS questionnaire: A patient-based digital tool to monitor symptoms of multiple sclerosis

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    Supplemental material, sj-docx-1-dhj-10.1177_20552076231173531 for Development and usability testing of your MS questionnaire: A patient-based digital tool to monitor symptoms of multiple sclerosis by Gavin Giovannoni, Enrique Alvarez, Ellen Tutton, Olaf Hoffmann, Yan Xu, Patrick Vermersch, Celia Oreja-Guevara, Maria Trojano, Ralf Gold, René Robles-Cedeño, Mudeer Khwaja, Bianca Stadler, Jo Vandercappellen and Tjalf Ziemssen in DIGITAL HEALTH</p

    sj-png-3-dhj-10.1177_20552076231173531 - Supplemental material for Development and usability testing of your MS questionnaire: A patient-based digital tool to monitor symptoms of multiple sclerosis

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    Supplemental material, sj-png-3-dhj-10.1177_20552076231173531 for Development and usability testing of your MS questionnaire: A patient-based digital tool to monitor symptoms of multiple sclerosis by Gavin Giovannoni, Enrique Alvarez, Ellen Tutton, Olaf Hoffmann, Yan Xu, Patrick Vermersch, Celia Oreja-Guevara, Maria Trojano, Ralf Gold, René Robles-Cedeño, Mudeer Khwaja, Bianca Stadler, Jo Vandercappellen and Tjalf Ziemssen in DIGITAL HEALTH</p

    sj-docx-6-dhj-10.1177_20552076231173531 - Supplemental material for Development and usability testing of your MS questionnaire: A patient-based digital tool to monitor symptoms of multiple sclerosis

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    Supplemental material, sj-docx-6-dhj-10.1177_20552076231173531 for Development and usability testing of your MS questionnaire: A patient-based digital tool to monitor symptoms of multiple sclerosis by Gavin Giovannoni, Enrique Alvarez, Ellen Tutton, Olaf Hoffmann, Yan Xu, Patrick Vermersch, Celia Oreja-Guevara, Maria Trojano, Ralf Gold, René Robles-Cedeño, Mudeer Khwaja, Bianca Stadler, Jo Vandercappellen and Tjalf Ziemssen in DIGITAL HEALTH</p

    sj-png-4-dhj-10.1177_20552076231173531 - Supplemental material for Development and usability testing of your MS questionnaire: A patient-based digital tool to monitor symptoms of multiple sclerosis

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    Supplemental material, sj-png-4-dhj-10.1177_20552076231173531 for Development and usability testing of your MS questionnaire: A patient-based digital tool to monitor symptoms of multiple sclerosis by Gavin Giovannoni, Enrique Alvarez, Ellen Tutton, Olaf Hoffmann, Yan Xu, Patrick Vermersch, Celia Oreja-Guevara, Maria Trojano, Ralf Gold, René Robles-Cedeño, Mudeer Khwaja, Bianca Stadler, Jo Vandercappellen and Tjalf Ziemssen in DIGITAL HEALTH</p

    sj-png-5-dhj-10.1177_20552076231173531 - Supplemental material for Development and usability testing of your MS questionnaire: A patient-based digital tool to monitor symptoms of multiple sclerosis

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    Supplemental material, sj-png-5-dhj-10.1177_20552076231173531 for Development and usability testing of your MS questionnaire: A patient-based digital tool to monitor symptoms of multiple sclerosis by Gavin Giovannoni, Enrique Alvarez, Ellen Tutton, Olaf Hoffmann, Yan Xu, Patrick Vermersch, Celia Oreja-Guevara, Maria Trojano, Ralf Gold, René Robles-Cedeño, Mudeer Khwaja, Bianca Stadler, Jo Vandercappellen and Tjalf Ziemssen in DIGITAL HEALTH</p

    sj-docx-2-dhj-10.1177_20552076231173531 - Supplemental material for Development and usability testing of your MS questionnaire: A patient-based digital tool to monitor symptoms of multiple sclerosis

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    Supplemental material, sj-docx-2-dhj-10.1177_20552076231173531 for Development and usability testing of your MS questionnaire: A patient-based digital tool to monitor symptoms of multiple sclerosis by Gavin Giovannoni, Enrique Alvarez, Ellen Tutton, Olaf Hoffmann, Yan Xu, Patrick Vermersch, Celia Oreja-Guevara, Maria Trojano, Ralf Gold, René Robles-Cedeño, Mudeer Khwaja, Bianca Stadler, Jo Vandercappellen and Tjalf Ziemssen in DIGITAL HEALTH</p

    Bonnie Jo Campbell, 33rd Annual ODU Literary Festival

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    Bonnie Jo Campbell is the author of Women and Other Animals, Q Road, and American Salvage. She is the winner of the AWP Award for Short Fiction and the Southern Review’s 2008 Eudora Welty Prize. Her stories have appeared in Southern Review, Kenyon Review, and Ontario Review. American Salvage was a 2009 finalist for the National Book Award in Fiction
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