13 research outputs found
Genetic features of platinum-resistant ovarian cancer patients
No full textDubinina V. G., Rybin A. I., Mihailenko O. V., Kuznetsova O. V. Genetic features of platinum-resistant ovarian cancer patients. Journal of Health Sciences. 2014;4(14):50-56. ISSN 1429-9623 / 2300-665X.
http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2814%29%3A50-56
http://ojs.ukw.edu.pl/index.php/johs/article/view/2014%3B4%2814%29%3A50-56
https://pbn.nauka.gov.pl/works/510233
DOI: 10.5281/zenodo.13271
http://dx.doi.org/10.5281/zenodo.13271
The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1107. (17.12.2013).
© The Author (s) 2014;
This article is published with open access at Licensee Open Journal Systems of Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
Conflict of interest: None declared. Received: 15.11.2014. Revised 05.12.2014. Accepted: 08.12.2014.
Genetic features of platinum-resistant ovarian cancer patients
V. G. Dubinina, A. I. Rybin, O. V. Mihailenko, O. V. Kuznetsova
Odessa National Medical University
Abstract
The authors try to decide a problem of ovarian cancer resistance to platinum drugs by the way of correlation finding between platinum-resistance of tumor and presence of gene mutations in the patient. It was shown a variety of options for BRCA gene mutations in patients with ovarian cancer: BRCA 1 (185delAG) - 64,2%, BRCA 1 (5382 insC) - 55,7%, and BRCA 2 (6174delT) - 53,8%. Authors discovered a significant positive correlation between carriage of mutations in the BRCA genes 1/2 and the sensitivity of malignant ovarian tumors to chemotherapy with platinum. Mutations in these genes occurred significantly more often in patients with platinum-sensitive ovarian cancer.
Key words: ovarian cancer, treatment, resistance to platinum, mutation of genes, BRCA 1, BRCA 2.Dubinina V. G., Rybin A. I., Mihailenko O. V., Kuznetsova O. V. Genetic features of platinum-resistant ovarian cancer patients. Journal of Health Sciences. 2014;4(14):50-56. ISSN 1429-9623 / 2300-665X.
http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2814%29%3A50-56
http://ojs.ukw.edu.pl/index.php/johs/article/view/2014%3B4%2814%29%3A50-56
https://pbn.nauka.gov.pl/works/510233
DOI: 10.5281/zenodo.13271
http://dx.doi.org/10.5281/zenodo.1327
